Humalog Mix 50 100IU/ml Kwikpen

Humalog Mix 50 100IU/ml Kwikpen is a pre-filled insulin injection pen containing insulin lispro 100 IU/ml in a Mix 50 formulation — 50% rapid-acting insulin lispro solution and 50% insulin lispro protamine suspension, which provides both a fast onset of action and a longer intermediate-acting cover. It is used in the management of diabetes mellitus (type 1 and type 2) to help control blood glucose levels around meal times and between meals.

As an insulin product, Humalog Mix 50 Kwikpen is strictly a prescription-only medicine in Malaysia and is never sold without a doctor’s prescription. Treatment must be initiated and monitored by a doctor, who will determine the correct starting dose, injection schedule, and any adjustments based on regular blood glucose monitoring; through DoctorOnCall, patients with an existing valid prescription or those who complete an online consultation with a doctor can have this medicine assessed, prescribed where appropriate, and dispensed under pharmacist supervision.

Insulin lispro is a rapid-acting insulin analogue that lowers blood glucose by promoting glucose uptake into peripheral tissues, particularly skeletal muscle and fat, and by suppressing glucose production by the liver. In the Mix 50 formulation, the soluble lispro component acts quickly after injection to control the glucose rise from a meal, while the protamine-suspended lispro component is absorbed more slowly, providing a longer intermediate action between meals.

This medicine must be used exactly as prescribed by your doctor, who will explain the injection technique, injection sites (such as the abdomen, thigh, or upper arm), and how to rotate sites to reduce the risk of lipodystrophy. The Kwikpen must be gently rolled and tipped (not shaken) to remix the suspension evenly before each injection, and a new needle should be used for every dose; do not adjust the dose or stop using this medicine without first consulting your prescribing doctor.

Dosage is individualised and must be determined and adjusted by a doctor based on blood glucose monitoring results, meal patterns, activity level, and overall diabetes control; there is no standard over-the-counter dose. Doses are typically given shortly before or immediately after a meal, exactly as instructed by the prescribing doctor, and should never be changed without medical advice.

An unopened Humalog Mix 50 Kwikpen should be stored refrigerated and is generally stable until the expiry date printed on the pen and carton when kept under these conditions. Once a pen is in use (opened), it is typically only usable for up to 28 days as advised by the prescribing doctor or pharmacist, after which any remaining insulin in that pen must be discarded even if it has not run out.

Store unopened Kwikpens in a refrigerator at 2°C to 8°C; do not freeze, and do not use if the insulin has been frozen. Once in use, the pen currently being used may generally be kept at room temperature below 30°C, away from direct heat and sunlight, and must be discarded after the in-use period advised by your doctor or pharmacist. Always keep out of the sight and reach of children, and never share your insulin pen with another person.

• Known hypersensitivity to insulin lispro or any other ingredient in the pen
• Episodes of hypoglycaemia that have not been discussed and managed with your doctor
• Use without proper medical supervision, blood glucose monitoring, and dose titration by a doctor

• Oral antidiabetic medicines, which may need dose adjustment when combined with insulin
• Corticosteroids, which can raise blood glucose and affect insulin requirements
• Beta-blockers, which may mask the warning symptoms of hypoglycaemia
• Alcohol, which can increase the risk of hypoglycaemia
• Missed or delayed meals, which significantly increase the risk of hypoglycaemia after an insulin dose

• Never change your insulin dose or schedule without your doctor’s advice
• Always check your blood glucose as instructed and know the signs of hypoglycaemia
• Rotate injection sites regularly to prevent lipodystrophy
• Roll and gently tip the pen to remix the suspension before each use; do not shake vigorously
• Carry a fast-acting source of sugar with you in case of hypoglycaemia
• Attend regular follow-up appointments with your doctor to monitor overall diabetes control

Humalog Mix 50 Kwikpen is a prescription-only injectable insulin and must always be used under the ongoing supervision of a doctor, with regular blood glucose monitoring and periodic review of the treatment plan. Correct storage before first use (refrigeration between 2°C and 8°C, never frozen) and correct injection technique are essential to ensure the medicine works as expected; patients should be trained by a healthcare professional on how to use the Kwikpen device, rotate injection sites, and recognise and manage hypoglycaemia before starting treatment. Through DoctorOnCall, an online consultation with a doctor is required before this medicine can be prescribed and dispensed.