Lenzetto 1.53mg Transdermal Spray

Lenzetto 1.53mg Transdermal Spray is a hormone replacement therapy (HRT) product containing estradiol, the active ingredient, delivered directly through the skin as a fine metered spray. It is used to relieve moderate to severe menopausal symptoms such as hot flushes, night sweats, and vaginal dryness that occur when a woman’s natural oestrogen levels fall during and after menopause.

Because estradiol is a potent hormone that must be dosed and monitored individually based on a woman’s symptoms, medical history, and risk factors, Lenzetto is a prescription-only medication in Malaysia. Customers can only obtain it through DoctorOnCall after completing an online consultation, during which a doctor reviews suitability and issues a valid prescription before the order is dispensed.

Lenzetto delivers estradiol through the skin into the bloodstream, bypassing the first pass through the liver that occurs with oral hormone tablets. Once absorbed, the estradiol tops up the body’s declining oestrogen levels, helping to stabilise the hormonal fluctuations responsible for hot flushes, night sweats, mood changes, and thinning of the vaginal lining that are common around menopause.

Lenzetto must only be used exactly as prescribed by the assessing doctor. It is typically sprayed once daily onto a clean, dry area of the inner forearm, allowed to air-dry for a couple of minutes before clothing touches the site, and the application area should be rotated slightly each day. Hands should be washed after each application, and the sprayed skin should not be washed, rubbed, or covered with sunscreen or moisturiser for at least one hour afterwards.

The usual starting dose is one spray (1.53mg estradiol) once daily, and the prescribing doctor may adjust this up to a maximum of three sprays a day depending on how symptoms respond. Dosage must never be increased, decreased, or stopped abruptly without medical advice, as the appropriate dose depends on individual symptom control and risk assessment.

Lenzetto should be used within the manufacturer’s stated shelf life printed on the carton and pump bottle, and should not be used past its expiry date. Once first opened, the metered-dose pump should be used within the period stated in the product leaflet, after which it should be discarded even if some solution remains.

Store Lenzetto below 25°C in a cool, dry place away from direct sunlight and out of reach of children and pets. As the spray contains alcohol and is flammable, keep it away from naked flames, lit cigarettes, and other sources of ignition until the sprayed area has fully dried.

• Known, past, or suspected breast cancer
• Known or suspected oestrogen-dependent cancers
• Undiagnosed abnormal vaginal bleeding
• Current or past venous thromboembolism (deep vein thrombosis or pulmonary embolism)
• Active or recent arterial thromboembolic disease, such as heart attack or stroke
• Severe liver disease or abnormal liver function
• Known or suspected pregnancy, or breastfeeding

• Enzyme-inducing medicines such as rifampicin, carbamazepine, and phenytoin may reduce the effectiveness of estradiol
• St John’s Wort (a herbal supplement) can lower estradiol levels in the blood
• Some antibiotics and antifungal medicines may alter how estradiol is broken down in the body
• Concurrent use with blood thinners or anticoagulants should be discussed with a doctor, as HRT can affect clotting risk
• Smoking increases the risk of blood clots when combined with hormone therapy

• Apply Lenzetto at roughly the same time each day for consistent hormone levels
• Allow the sprayed area to air-dry fully before dressing or applying other skin products
• Never apply near an open flame or while smoking until the site is completely dry
• Rotate the exact application spot slightly to reduce skin irritation
• Keep up with scheduled follow-up consultations and breast/health screenings while on HRT
• Report any unusual bleeding, leg swelling, or chest pain to your doctor immediately

Lenzetto is dispensed only against a valid prescription obtained through an online consultation with a DoctorOnCall doctor, who will assess your medical history, menopausal symptoms, and risk factors such as personal or family history of breast cancer or blood clots before prescribing. Hormone replacement therapy is generally recommended at the lowest effective dose for the shortest duration needed to control symptoms, with periodic medical review to reassess ongoing need and monitor for side effects. Continuing regular follow-ups, including breast examinations and blood pressure checks as advised by your doctor, is an important part of using this medicine safely.