Do I need a prescription to buy Lenzetto 1.53mg Transdermal Spray?

No. Lenzetto 1.53mg Transdermal Spray is a non-prescription product and can be ordered without a prescription. It is still dispensed by a registered pharmacist on DoctorOnCall.

What does Lenzetto 1.53mg Transdermal Spray contain?

Lenzetto 1.53mg Transdermal Spray is a transdermal spray containing Estradiol hemihydrate (equivalent to 1.53mg estradiol per spray). The full ingredient list is shown in the Composition or Ingredients section on this page and on the product packaging.

What pack sizes does Lenzetto 1.53mg Transdermal Spray come in?

It is supplied in a pack size of 8.1ml. Choose the pack size you need from the options shown on this page before adding the item to your cart.

Why is there no information here about what Lenzetto 1.53mg Transdermal Spray is for?

This page is limited to product, safety and handling information in line with Malaysian rules on medicine information. If you want advice on whether this product suits you, book an online consultation with a doctor or pharmacist on DoctorOnCall.

How should I use Lenzetto 1.53mg Transdermal Spray?

Follow the instructions printed on the label and in the leaflet supplied with the pack, and do not exceed the stated amount or duration. Handling steps are set out in the Directions for Use section on this page.

Can I speak to a doctor or pharmacist about Lenzetto 1.53mg Transdermal Spray before I buy it?

Yes. DoctorOnCall offers online consultations with licensed doctors and registered pharmacists, so you can ask about this product, your existing medicines, or anything on the label before you place an order.

What should I do if I notice side effects after using Lenzetto 1.53mg Transdermal Spray?

Stop using the product and speak to a doctor or pharmacist about any reaction that concerns you. Seek medical care immediately for signs of a severe reaction such as difficulty breathing, swelling of the face, lips or throat, or a widespread rash. Reported reactions are listed in the Side Effects section on this page.

How long will delivery take?

Within Malaysia, standard delivery takes 3 to 5 working days. Same-day delivery is available in the Klang Valley for orders placed before 12pm; orders placed after 12pm arrive by the end of the next day. Orders to Singapore are sent as international deliveries and take 5 to 9 working days. A lump-sum shipping and handling fee applies to every overseas delivery and is shown at checkout.

What payment methods can I use?

Customers in Malaysia can pay by FPX online banking, credit or debit card (Visa and Mastercard), and supported e-wallets including Touch ‘n Go eWallet, GrabPay and ShopeePay. FPX and local e-wallets are tied to Malaysian bank and wallet accounts, so if your delivery address is in Singapore, use the payment options displayed at checkout for that address rather than assuming the same list applies.

Can Lenzetto 1.53mg Transdermal Spray be delivered to Singapore?

Yes. DoctorOnCall ships to Singapore as an international order dispatched from Malaysia, arriving in 5 to 9 working days with a lump-sum shipping and handling fee. Singapore’s Health Sciences Authority (HSA) allows personal imports of up to three months’ supply of a medicine for your own use or an immediate family member’s, as long as it contains no controlled drugs, psychotropic substances or prohibited items. Keep the product in its original labelled packaging and keep a copy of your prescription or doctor’s letter with it. Quantities above three months’ supply, and medicines containing controlled substances, require prior HSA approval.

Is Lenzetto 1.53mg Transdermal Spray registered with the authorities?

Products listed on DoctorOnCall are registered with Malaysia’s Ministry of Health for supply in Malaysia, and each pack carries its MAL registration number. An order delivered to Singapore arrives as a personal import of a Malaysia-registered product; HSA product registration is not required for personal-use quantities, but it is also not the same as a product registered for sale in Singapore. If you need a locally registered Singapore product, buy it from a pharmacy in Singapore.

Who do I contact if there is a problem with my order?

DoctorOnCall’s customer care team handles order, delivery and product queries through the contact channels on the site, including WhatsApp and the online help centre. For deliveries to Singapore, allow more time before chasing an order than you would for a local Malaysian delivery, as the parcel passes through customs clearance and tracking updates can appear later in the journey.

Lenzetto 1.53mg Estradiol Transdermal Spray - Menopause HRT Malaysia

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Lenzetto 1.53mg Transdermal Spray

Manufacturer Gedeon Richter

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Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester

Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated: October 31, 2026

Overview

Lenzetto 1.53mg Transdermal Spray is a transdermal spray with Estradiol hemihydrate (equivalent to 1.53mg estradiol per spray) declared as its active content. It is supplied in a pack size of 8.1ml.

This is a non-prescription product and can be purchased without a prescription. Only product, safety and handling details are published on this page.

An online consultation with a DoctorOnCall doctor or pharmacist is available for this product, and a registered pharmacist reviews each order before dispatch to Malaysia or Singapore. Follow the directions on the label and on the leaflet inside the pack.

Directions for Use

Lenzetto must only be used exactly as prescribed by the assessing doctor. It is typically sprayed once daily onto a clean, dry area of the inner forearm, allowed to air-dry for a couple of minutes before clothing touches the site, and the application area should be rotated slightly each day. Hands should be washed after each application, and the sprayed skin should not be washed, rubbed, or covered with sunscreen or moisturiser for at least one hour afterwards.

Dosage

The usual starting dose is one spray (1.53mg estradiol) once daily, and the prescribing doctor may adjust this up to a maximum of three sprays a day depending on how symptoms respond. Dosage must never be increased, decreased, or stopped abruptly without medical advice, as the appropriate dose depends on individual symptom control and risk assessment.

Shelf Life

Lenzetto should be used within the manufacturer’s stated shelf life printed on the carton and pump bottle, and should not be used past its expiry date. Once first opened, the metered-dose pump should be used within the period stated in the product leaflet, after which it should be discarded even if some solution remains.

Storage Instructions

Store Lenzetto below 25°C in a cool, dry place away from direct sunlight and out of reach of children and pets. As the spray contains alcohol and is flammable, keep it away from naked flames, lit cigarettes, and other sources of ignition until the sprayed area has fully dried.

Side Effects

Nausea or vomiting
Breast tenderness or swelling
Headache or migraine
Bloating
Mood changes
Spotting or breakthrough bleeding
Increased risk of blood clots with long-term use

Contraindications

Known, past, or suspected breast cancer
Known or suspected oestrogen-dependent cancers
Undiagnosed abnormal vaginal bleeding
Current or past venous thromboembolism (deep vein thrombosis or pulmonary embolism)
Active or recent arterial thromboembolic disease, such as heart attack or stroke
Severe liver disease or abnormal liver function
Known or suspected pregnancy, or breastfeeding

Drug / Food Interactions

Enzyme-inducing medicines such as rifampicin, carbamazepine, and phenytoin may reduce the effectiveness of estradiol
St John’s Wort (a herbal supplement) can lower estradiol levels in the blood
Some antibiotics and antifungal medicines may alter how estradiol is broken down in the body
Concurrent use with blood thinners or anticoagulants should be discussed with a doctor, as HRT can affect clotting risk
Smoking increases the risk of blood clots when combined with hormone therapy

Quick Tips

Apply Lenzetto at roughly the same time each day for consistent hormone levels
Allow the sprayed area to air-dry fully before dressing or applying other skin products
Never apply near an open flame or while smoking until the site is completely dry
Rotate the exact application spot slightly to reduce skin irritation
Keep up with scheduled follow-up consultations and breast/health screenings while on HRT
Report any unusual bleeding, leg swelling, or chest pain to your doctor immediately

Ingredients / Active Ingredients

Oestradiol

Estradiol hemihydrate (equivalent to 1.53mg estradiol per spray)
Ethanol
Diethylene glycol monoethyl ether
Octisalate

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Not Advisable

Not recommended in patients with liver disease.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Relevant Information

Lenzetto is dispensed only against a valid prescription obtained through an online consultation with a DoctorOnCall doctor, who will assess your medical history, menopausal symptoms, and risk factors such as personal or family history of breast cancer or blood clots before prescribing. Hormone replacement therapy is generally recommended at the lowest effective dose for the shortest duration needed to control symptoms, with periodic medical review to reassess ongoing need and monitor for side effects. Continuing regular follow-ups, including breast examinations and blood pressure checks as advised by your doctor, is an important part of using this medicine safely.