Lodoz 2.5/6.25mg Tablet
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Overview
Lodoz 2.5/6.25mg Tablet is a fixed-dose combination containing bisoprolol and hydrochlorothiazide (2.5mg/6.25mg), used to treat high blood pressure (hypertension) in patients who are not adequately controlled on either component alone. Bisoprolol is a beta-blocker and hydrochlorothiazide is a thiazide diuretic (‘water pill’).
The two ingredients lower blood pressure through complementary mechanisms: bisoprolol slows and steadies the heart rate and reduces the force of its contractions, while hydrochlorothiazide helps the kidneys remove excess salt and water from the body, reducing blood volume. Together they provide greater blood pressure reduction than either medicine used alone.
How it Works
Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, contractility, and the heart’s oxygen demand. Hydrochlorothiazide acts on the kidney’s distal convoluted tubule, inhibiting sodium and chloride reabsorption so that more sodium and water are excreted in urine, which lowers circulating blood volume and, over time, reduces blood vessel resistance.
Directions for Use
Take Lodoz 2.5/6.25mg Tablet once daily in the morning, with or without food, at about the same time each day, to avoid the increased urination from the diuretic component disturbing your sleep. Swallow the tablet whole with a glass of water. Do not stop this medicine abruptly, as suddenly stopping a beta-blocker can trigger a rebound rise in heart rate, blood pressure, or chest pain – your doctor will taper the dose gradually if it needs to be discontinued.
Dosage
Lodoz 2.5/6.25mg Tablet is usually taken once daily in the morning, at the strength your doctor has determined is right for your blood pressure control. Your doctor will periodically review your response, blood pressure readings, and blood electrolyte and kidney function tests while you are on this combination.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Dizziness or light-headedness
- Increased urination
- Headache
- Nausea or vomiting
- Muscle cramps or weakness
- Sensitivity to sunlight
Contraindications
- Known hypersensitivity to bisoprolol, hydrochlorothiazide, other sulfonamide-derived medicines, or any ingredient in this product
- Severe bradycardia (very slow heart rate) or high-degree heart block without a pacemaker
- Decompensated heart failure or cardiogenic shock
- Severe asthma or bronchospastic lung disease
- Anuria (inability to produce urine) or severe, uncorrected low blood potassium/sodium
Drug / Food Interactions
- Verapamil or diltiazem combined with bisoprolol can cause severe bradycardia or heart block
- NSAIDs may reduce the blood-pressure-lowering effect of both components
- Lithium levels may rise when combined with hydrochlorothiazide, increasing toxicity risk
- Digoxin toxicity risk increases if hydrochlorothiazide causes low blood potassium
Quick Tips
- Take your dose in the morning to reduce night-time trips to the bathroom
- Do not stop this medicine suddenly – your doctor will reduce the dose gradually if it needs to be stopped
- Rise slowly from sitting or lying down to reduce light-headedness
- Attend scheduled blood tests to monitor your kidney function and electrolytes
Frequently Asked Questions
What is Lodoz 2.5/6.25mg Tablet used for?
Lodoz 2.5/6.25mg Tablet is used to treat high blood pressure in patients whose blood pressure is not fully controlled by a single medicine, combining a beta-blocker and a diuretic in one tablet.
Why do I need to take this medicine in the morning?
Taking it in the morning helps the diuretic effect occur during waking hours, so you are less likely to need to urinate frequently during the night.
Can I stop taking this medicine once my blood pressure is normal?
No, do not stop without consulting your doctor. High blood pressure usually has no symptoms, and abruptly stopping a beta-blocker can cause a rebound increase in heart rate or blood pressure, or chest pain.
Will this medicine affect my blood test results?
Yes, your doctor will periodically check your blood potassium, sodium, and kidney function, as the diuretic component can affect these values over time.
What should I do if I miss a dose of Lodoz 2.5/6.25mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Lodoz 2.5/6.25mg Tablet from DoctorOnCall?
Yes, Lodoz 2.5/6.25mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Lodoz 2.5/6.25mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Lodoz 2.5/6.25mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Lodoz 2.5/6.25mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Lodoz 2.5/6.25mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Lodoz 2.5/6.25mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Bisoprolol / Hydrochlorothiazide 2.5mg/6.25mg
Safety Advice
Pregnancy
There is no adequate data on use during pregnancy. Consult a doctor before use.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
