Progyluton Tablet

Rx
Brand Bayer
  • FDA Approved
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  • Discreet Packaging
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Save: RM10.01   15% OFF

Prescription Required

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Progyluton Tablet contains Estradiol valerate and is presented as a tablet. It is supplied in a pack size of 21s.

It is classified as a non-prescription medicine, so no prescription is needed to order it. Under Malaysian rules for medicine information, this page carries product, safety and handling information only.

You can consult a doctor or pharmacist online on DoctorOnCall about this product before or after you order. Every order is checked by a registered pharmacist before it is delivered. Always read the label and the leaflet supplied with the pack.

Directions for Use

Progyluton Tablet must only be used under the direction of a doctor following an online or in-clinic consultation with DoctorOnCall. Tablets are taken once daily at approximately the same time each day, in the order printed on the calendar pack, starting with the white (oestrogen-only) tablets followed by the light brown (combined) tablets. After completing all 21 tablets, a 7-day tablet-free interval is observed before starting the next pack, during which a withdrawal bleed similar to a period usually occurs.

Dosage

The typical regimen is one tablet daily for 21 consecutive days (11 white tablets followed by 10 light brown tablets), followed by a 7-day break with no tablets, then the cycle is repeated. Your doctor will determine the most appropriate starting point and duration of treatment based on your symptoms, medical history, and response, and treatment is generally reviewed periodically to confirm the lowest effective dose is being used for the shortest necessary duration.

Storage Instructions

Store Progyluton Tablet below 30°C in a dry place, away from direct sunlight and out of reach of children. Keep the tablets in their original calendar pack until they are due to be taken so the correct sequence is followed.

Side Effects

  • Nausea or vomiting
  • Breast tenderness or swelling
  • Headache or migraine
  • Bloating
  • Mood changes
  • Spotting or breakthrough bleeding
  • Increased risk of blood clots with long-term use

Contraindications

  • Known, past, or suspected breast cancer
  • Known or suspected oestrogen-dependent cancer, such as endometrial cancer
  • Undiagnosed abnormal vaginal bleeding
  • Current or past history of venous thromboembolism (deep vein thrombosis or pulmonary embolism)
  • Active or recent arterial thromboembolic disease, such as stroke or heart attack
  • Severe liver disease or liver tumour
  • Pregnancy or suspected pregnancy
  • Known hypersensitivity to estradiol, norgestrel, or any tablet ingredient

Drug / Food Interactions

  • Enzyme-inducing medicines such as rifampicin, phenytoin, carbamazepine, and St John’s Wort may reduce the effectiveness of Progyluton Tablet
  • Certain antibiotics and antifungals may alter hormone levels when taken together
  • May affect the required dose of thyroid replacement therapy
  • Can influence blood clotting parameters in patients taking anticoagulants
  • Grapefruit juice may increase estradiol levels in some individuals

Quick Tips

  • Take each tablet in the exact order printed on the calendar pack to maintain the correct hormone sequence
  • Take your tablet at the same time every day to help you remember and maintain steady hormone levels
  • Attend scheduled follow-up reviews with your doctor to reassess whether continued HRT is appropriate
  • Report any unexpected vaginal bleeding, breast changes, or leg swelling to your doctor promptly
  • Do not share this medicine with anyone else, even if they have similar menopausal symptoms

Ingredients / Active Ingredients

  • Estradiol valerate
  • Norgestrel
  • Lactose monohydrate
  • Maize starch
  • Povidone
  • Magnesium stearate
  • Talc
  • Colouring agents (tablet coating)

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Not Advisable

Not recommended in patients with liver disease.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Relevant Information

Because Progyluton Tablet is a systemic hormone therapy, DoctorOnCall’s doctors will review your personal and family medical history, including any history of blood clots, cancer, liver disease, or cardiovascular disease, before prescribing. HRT is generally recommended at the lowest effective dose for the shortest duration needed to control symptoms, with periodic reassessment, and it is not intended as a contraceptive.

Frequently Asked Questions

Product Specifications

BrandBayer
ClassificationPrescription medicine
Ingredients / Active IngredientsOestradiol
Pack Size21s
Shelf LifeProgyluton Tablet is typically stable for up to the expiry date printed on the pack when stored under the manufacturer’s recommended conditions and left unopened. Do not use the medicine after the expiry date has passed.

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Important Medical Information

💊 Recommended Dosage:

The typical regimen is one tablet daily for 21 consecutive days (11 white tablets followed by 10 light brown tablets), followed by a 7-day break with no tablets, then the cycle is repeated. Your doctor will determine the most appropriate starting point and duration of treatment based on your symptoms, medical history, and response, and treatment is generally reviewed periodically to confirm the lowest effective dose is being used for the shortest necessary duration.

🛑 Contraindications (Do not use if):
  • Known, past, or suspected breast cancer
  • Known or suspected oestrogen-dependent cancer, such as endometrial cancer
  • Undiagnosed abnormal vaginal bleeding
  • Current or past history of venous thromboembolism (deep vein thrombosis or pulmonary embolism)
  • Active or recent arterial thromboembolic disease, such as stroke or heart attack
  • Severe liver disease or liver tumour
  • Pregnancy or suspected pregnancy
  • Known hypersensitivity to estradiol, norgestrel, or any tablet ingredient
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Breast tenderness or swelling
  • Headache or migraine
  • Bloating
  • Mood changes
  • Spotting or breakthrough bleeding
  • Increased risk of blood clots with long-term use
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.