Progynova (Oestradiol) Tablet

Hormone-based tablet available in 1mg and 2mg strengths.

Brand Bayer
Manufacturer Bayer
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Key Information

What is Progynova Tablet?

What is Progynova Tablet?

  • Progynova Tablet is an oral hormone-based medicine manufactured by Bayer.
  • It is available in 1mg and 2mg strengths, with each tablet containing estradiol valerate in the amount stated on the pack. The tablets have a coated finish, and the two strengths have different tablet colours.
  • The product is supplied in blister packaging, with 28 tablets per pack. A larger pack containing three sets of 28 tablets is also listed for the 2mg strength on DoctorOnCall.
  • Check the selected variant carefully to confirm the strength and quantity before placing your order.
Is this strength right for me?

Is this strength right for me?

  • Progynova is available in 1mg and 2mg strengths. Check the strength printed on the carton and blister pack to ensure it matches the product selected.
  • Read the package leaflet carefully before taking the tablets. Pay particular attention to the dosage instructions, warnings and precautions.
  • If you have a history of blood clots, liver disease, unexplained vaginal bleeding or hormone-sensitive conditions, check with a pharmacist or healthcare professional before taking this medicine.
  • Do not change the dosage or combine it with other hormone medicines without appropriate professional advice.
  • If you are pregnant, think you may be pregnant or are breastfeeding, seek professional advice before taking Progynova.
Delivery, packaging and ordering

Delivery, packaging and ordering

  • Select the required strength and available pack size on the DoctorOnCall product page.
  • Review the product details and checkout information before completing your order.
  • Orders are processed by a registered pharmacist in accordance with the pharmacy's procedures.
  • When your parcel arrives, check the product name, strength, pack quantity, batch number and expiry date.
  • Contact DoctorOnCall customer support if the item differs from your order or the packaging arrives damaged.
Side effects, safety and when to seek help

Side effects, safety and when to seek help

  • Progynova may cause side effects such as headache, nausea, breast tenderness, abdominal discomfort or bloating.
  • Before taking the tablets, review the warnings concerning blood clots, liver conditions and unusual vaginal bleeding.
  • Tell your pharmacist or healthcare professional about any medicines or supplements you take, particularly other hormone products, as some combinations may require additional precautions.
  • Get urgent medical attention for sudden chest pain, difficulty breathing, sudden severe headache, changes in vision, or pain and swelling in one leg. These may indicate a serious reaction requiring immediate assessment.

How to take your Progynova Tablet

  1. Step 1

    Check the packaging. Confirm whether you have the 1mg or 2mg strength and read the accompanying leaflet before taking the first tablet.

  2. Step 2

    Follow the product instructions. Take the tablets according to the directions provided with the medicine. Do not change the amount or schedule on your own.

  3. Step 3

    Swallow with water. The product information states that Progynova tablets are taken orally. Follow the leaflet for the correct administration instructions.

  4. Step 4

    Check before combining medicines. Tell your pharmacist about other medicines, supplements or hormone products you take. If you experience a serious or unexpected reaction, stop and seek appropriate medical advice.

Delivery & Returns

  • Malaysia-wide delivery
  • No prescription needed
  • Licensed pharmacy
  • Doctor consultation

If your order arrives damaged

  • Do not take Progynova if the carton is damaged, the blister foil is torn or open, or the packaging appears to have been tampered with.
  • Check that the product name, strength and pack quantity match your order.
  • Take clear photographs of the parcel, delivery label, carton and blister packaging.
  • Contact DoctorOnCall customer support through WhatsApp and provide your order details and photographs.
  • Keep the product and packaging until the support team advises you on the next steps.

Returns policy

For safety reasons, medicines may not be eligible for return or exchange once they have left the pharmacy, except where the applicable policy allows it for a verified delivery issue.

If your order arrives damaged, incomplete or incorrect, contact customer support within 24 hours of delivery. Include your order details and photographs so the team can assess the issue. Do not take the product if the blister packaging is damaged or its quality is in question.

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Dosage

The typical dose is one tablet daily, often used as a starting dose for HRT or as a maintenance dose once symptoms are controlled on a higher strength, with your doctor adjusting up or down as needed to find the lowest effective dose for the shortest duration required.

Storage Instructions

Do

  • Follow the storage instructions printed on the carton or package leaflet.
  • Keep the tablets in their original blister packaging until needed.
  • Store the medicine in a dry place away from excessive heat and direct sunlight.
  • Keep it out of reach of children.
  • Check the expiry date before taking a tablet.

Don't

  • Don’t leave the medicine in a hot car or damp area.
  • Don’t remove tablets from the blister well before they are needed.
  • Don’t take tablets that are expired or have damaged packaging.
  • Don’t transfer tablets into unlabelled containers.
  • Don’t share your medicine with another person.

Side Effects

Progynova Tablet may cause side effects in some people. These reactions can vary between individuals and may change as the body adjusts to treatment. Monitor any new or persistent symptoms and consult your healthcare professional if you have concerns.

Breast Tenderness or Swelling

The breasts may feel tender, sensitive or swollen during treatment.

Nausea or Stomach Upset

Nausea or mild stomach discomfort may occur, particularly when starting treatment.

Headache

Headaches may occur during treatment. Seek medical advice if they are severe, persistent or unusual for you.

Bloating or Fluid Retention

You may notice abdominal bloating or mild swelling caused by fluid retention.

Mood Changes

Some people may notice changes in mood or emotional well-being during treatment.

Irregular Vaginal Bleeding

Spotting or breakthrough bleeding may occur, especially during the first few months of treatment.

When to Seek Medical Advice

Contact your healthcare professional if symptoms persist, worsen or interfere with daily activities. Seek prompt medical assessment for unusual, persistent or heavy vaginal bleeding.

Seek emergency medical attention for chest pain, sudden shortness of breath, sudden vision or speech changes, or painful swelling in one leg.

This information does not replace the product leaflet or advice from a healthcare professional. Do not change or stop prescribed treatment without discussing it with your healthcare professional.

Contraindications

  • Known, past, or suspected breast cancer or other oestrogen-dependent cancer
  • Undiagnosed abnormal vaginal bleeding
  • Current or past history of venous thromboembolism (blood clots) or a known clotting disorder
  • Active or recent arterial disease such as heart attack or stroke
  • Severe liver disease or liver tumours
  • Known or suspected pregnancy

Drug / Food Interactions

  • Enzyme-inducing medicines such as rifampicin, certain anticonvulsants (for example carbamazepine or phenytoin), and St John’s Wort may reduce the effectiveness of Progynova Tablet
  • Concurrent use with tamoxifen may reduce tamoxifen’s effectiveness and should be discussed with your doctor
  • Anticoagulants such as warfarin may require closer monitoring when started or stopped alongside HRT
  • Grapefruit juice may in some cases increase estradiol blood levels; discuss significant dietary changes with your doctor

Quick Tips

  • Progynova Tablet is often used as a starting or step-down dose — do not change your dose without your doctor’s guidance
  • Attend regular follow-up appointments, including breast checks and mammograms as recommended for your age group
  • Report any new, unusual, or heavy vaginal bleeding to your doctor promptly
  • Give the tablet a few weeks to take effect before assuming your current dose is not working, and discuss any concerns at your next review
  • Inform your doctor of any new medical conditions or medicines started while on Progynova Tablet

Ingredients / Active Ingredients

  • Estradiol valerate
  • Lactose monohydrate
  • Standard tablet binders and coating agents

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Not Advisable

Not recommended in patients with liver disease.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Relevant Information

Progynova Tablet is often the preferred starting strength for women beginning hormone replacement therapy, or a step-down option once menopausal symptoms have stabilised on a higher dose, reflecting the general principle of using the lowest effective HRT dose. Because HRT carries risks that vary with age, time since menopause, and personal health history, DoctorOnCall’s doctors review each customer individually through an online consultation and recommend appropriate monitoring, including periodic reassessment of ongoing need.

How to buy

Go to the DoctorOnCall website

Go to the DoctorOnCall website

Visit DoctorOnCall and search for Progynova Tablet. Choose the required strength and review the available pack sizes before adding the product to your cart.

Place your order

Place your order

Check your selection, enter your delivery details and follow the checkout instructions to complete your order.

Pharmacy processing

Pharmacy processing

Your order will be processed by the pharmacy in accordance with its procedures and applicable supply requirements. Check your order confirmation for updates.

Receive your delivery

Receive your delivery

When your parcel arrives, check that the packaging is intact and that the product name, strength, pack quantity and expiry date match your order. Read the accompanying leaflet before taking the tablets.

Frequently Asked Questions

Product Specifications

BrandProgynova
ManufacturerBayer Weimar GmbH und Co. KG
ClassificationNon-prescription
Ingredients / Active IngredientsOestradiol
Strength1mg or 2mg per tablet, depending on the selected variant
Pack Size28s, 28s x3
Shelf LifeRefer to the expiry date printed on the packaging
Dosage FormCoated tablet
RouteOral
DosageFollow the instructions supplied with the product
FrequencyRefer to the package leaflet
Pack ContentsDepends on the selected strength and pack size
StorageFollow the instructions on the carton and package leaflet
ExcipientsRefer to the package leaflet

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Important Medical Information

💊 Recommended Dosage:

The typical dose is one tablet daily, often used as a starting dose for HRT or as a maintenance dose once symptoms are controlled on a higher strength, with your doctor adjusting up or down as needed to find the lowest effective dose for the shortest duration required.

🛑 Contraindications (Do not use if):
  • Known, past, or suspected breast cancer or other oestrogen-dependent cancer
  • Undiagnosed abnormal vaginal bleeding
  • Current or past history of venous thromboembolism (blood clots) or a known clotting disorder
  • Active or recent arterial disease such as heart attack or stroke
  • Severe liver disease or liver tumours
  • Known or suspected pregnancy
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Breast tenderness or swelling
  • Headache or migraine
  • Bloating
  • Mood changes
  • Spotting or breakthrough bleeding
  • Increased risk of blood clots with long-term use
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.