Janumet XR 100/1000mg Tablet
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Prescription Required
Overview
Janumet XR 100/1000mg Tablet is a fixed-dose combination extended-release tablet containing sitagliptin 100mg and metformin hydrochloride (extended release) 1000mg, combining a dipeptidyl peptidase-4 (DPP-4) inhibitor with a biguanide. It is used, together with diet and exercise, to improve blood glucose control in adults with type 2 diabetes mellitus who need both medicines.
Sitagliptin preserves the body’s own incretin hormones to boost glucose-dependent insulin release and reduce glucagon secretion, while metformin lowers glucose production by the liver and improves insulin sensitivity in the body’s tissues. The extended-release metformin formulation releases the drug gradually, supporting once-daily dosing.
How it Works
Sitagliptin inhibits the DPP-4 enzyme, prolonging the action of incretin hormones that enhance glucose-dependent insulin secretion and suppress glucagon release after meals. Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. Together, these mechanisms lower blood glucose through complementary, largely non-overlapping pathways.
Directions for Use
Take Janumet XR 100/1000mg Tablet once daily with the evening meal, swallowing the tablet whole – do not crush, split, or chew it, as this is an extended-release formulation designed to release the medicine gradually. You may notice something resembling the tablet shell in your stool; this is expected and does not mean the medicine was not absorbed.
Dosage
Janumet XR 100/1000mg Tablet is usually taken once daily with the evening meal, with the specific strength selected by your doctor based on your current sitagliptin and metformin doses, blood glucose control, and kidney function. Your doctor will individualise and periodically review your dose, including checking kidney function before and during treatment.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea or vomiting
- Diarrhea
- Stomach discomfort or cramps
- Metallic taste in the mouth
- Loss of appetite
- Weight loss (in some cases)
Contraindications
- Known hypersensitivity to sitagliptin, metformin, or any ingredient in this product, or a history of a serious hypersensitivity reaction to any DPP-4 inhibitor
- Severe kidney impairment or acute kidney injury
- Diabetic ketoacidosis or a history of it
- Acute or chronic metabolic acidosis
- Conditions predisposing to tissue hypoxia (e.g. severe heart failure, respiratory failure, recent heart attack) due to lactic acidosis risk with metformin
Drug / Food Interactions
- Iodinated contrast media used in imaging studies require metformin to be temporarily withheld due to acute kidney injury and lactic acidosis risk
- Insulin or sulfonylureas may increase the risk of low blood sugar (hypoglycaemia) when combined – a lower dose of these medicines may be needed
- Alcohol increases the risk of lactic acidosis with metformin and should be limited
- Digoxin levels may be slightly increased with sitagliptin and monitoring may be advised if combined
Quick Tips
- Take with the evening meal to reduce stomach upset and support the once-daily regimen
- Swallow the tablet whole; never crush, split, or chew this extended-release formulation
- Maintain good hydration, especially during illness, hot weather, or reduced food/fluid intake
- Inform your doctor before any surgery, contrast imaging scan, or major illness, as this medicine may need to be temporarily stopped
- Seek urgent medical attention for severe or persistent abdominal pain, or symptoms of lactic acidosis
Frequently Asked Questions
What is Janumet XR 100/1000mg Tablet used for?
Janumet XR 100/1000mg Tablet combines sitagliptin and extended-release metformin to help control blood glucose in adults with type 2 diabetes, working through two complementary mechanisms alongside diet and exercise.
Why do I sometimes see something in my stool that looks like the tablet?
The extended-release metformin tablet has an outer shell designed to release the medicine gradually as it passes through the digestive tract; the empty shell can sometimes be seen in the stool afterwards. This is expected and does not mean the medicine was not absorbed.
Can I split or crush this tablet?
No, this tablet must be swallowed whole. Crushing, splitting, or chewing it would destroy the extended-release mechanism and could cause the medicine to be released too quickly, increasing the risk of side effects.
Can I take this medicine if I have kidney problems?
Metformin is not suitable for people with severe kidney impairment because of an increased risk of lactic acidosis, and sitagliptin’s effectiveness also depends on kidney function. Your doctor will check your kidney function before starting and periodically during treatment.
Do I need to stop this medicine before a scan with contrast dye or surgery?
Yes, your doctor or the hospital may instruct you to temporarily stop this medicine before and after receiving iodinated contrast dye for an X-ray/CT scan, or before major surgery, because of an increased risk of kidney problems and lactic acidosis. Always tell any doctor treating you that you are on this medicine.
What should I do if I miss a dose of Janumet XR 100/1000mg Tablet?
Take the missed dose with your evening meal as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not take two doses at once.
Can I buy Janumet XR 100/1000mg Tablet from DoctorOnCall?
Yes, Janumet XR 100/1000mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Janumet XR 100/1000mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Janumet XR 100/1000mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Janumet XR 100/1000mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Janumet XR 100/1000mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Janumet XR 100/1000mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Sitagliptin 100mg (as sitagliptin phosphate monohydrate)
- Metformin hydrochloride (extended-release) 1000mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
