Xigduo XR 10/500mg Tablet

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Manufacturer AstraZeneca
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Xigduo XR 10/500mg Tablet contains Dapagliflozin (as dapagliflozin propanediol monohydrate) and Metformin hydrochloride extended-release 10/500mg and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Xigduo XR 10/500mg Tablet are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Swallow the tablet whole with the evening meal; do not crush, split, or chew it, as this affects the extended-release action.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to dapagliflozin, metformin, or any ingredient in the tablet
  • Severe kidney impairment
  • Type 1 diabetes or diabetic ketoacidosis
  • Severe liver disease or conditions that increase the risk of lactic acidosis

Drug / Food Interactions

  • Iodinated contrast dye used in some imaging scans can affect kidney function – metformin may need to be paused around the time of the scan.
  • Diuretics (‘water pills’) can increase the risk of dehydration and low blood pressure when combined with dapagliflozin.
  • Other diabetes medicines, particularly insulin and sulfonylureas, can increase the risk of low blood sugar when combined.
  • Excess alcohol intake can increase the risk of lactic acidosis with metformin – avoid heavy or binge drinking.

Quick Tips

  • Drink adequate fluids, as dapagliflozin increases urination and fluid loss.
  • Practise good genital hygiene to help reduce the risk of yeast infections associated with this medicine.
  • Tell your doctor if you are scheduled for surgery or an imaging scan using contrast dye, as this medicine may need to be paused.
  • Watch for signs of low blood sugar (shakiness, sweating, confusion) if combined with insulin or sulfonylureas.

Ingredients / Active Ingredients

  • Dapagliflozin (as dapagliflozin propanediol monohydrate)
  • Metformin hydrochloride extended-release 10/500mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandAstraZeneca
ManufacturerAstraZeneca
ClassificationPrescription medicine
Ingredients / Active IngredientsMetformin
Pack Size28s
DosageThe dose is individualised by the treating doctor based on blood sugar control, kidney function, and any other diabetes medicines being used, generally taken once daily with the evening meal.
Shelf LifeRefer to the expiry date printed on the packaging.

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Important Medical Information

💊 Recommended Dosage:

The dose is individualised by the treating doctor based on blood sugar control, kidney function, and any other diabetes medicines being used, generally taken once daily with the evening meal.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to dapagliflozin, metformin, or any ingredient in the tablet
  • Severe kidney impairment
  • Type 1 diabetes or diabetic ketoacidosis
  • Severe liver disease or conditions that increase the risk of lactic acidosis
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.