Janumet XR 50/1000mg Tablet

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Brand MSD
Manufacturer MSD
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Janumet XR 50/1000mg Tablet is a prescription-only medicine (POM) that contains Sitagliptin 50mg (as sitagliptin phosphate monohydrate) and Metformin hydrochloride (extended-release) 1000mg. It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Janumet XR 50/1000mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Janumet XR 50/1000mg Tablet once daily with the evening meal, swallowing the tablet whole – do not crush, split, or chew it, as this is an extended-release formulation designed to release the medicine gradually. You may notice something resembling the tablet shell in your stool; this is expected and does not mean the medicine was not absorbed.

Dosage

Janumet XR 50/1000mg Tablet is usually taken once daily with the evening meal, with the specific strength selected by your doctor based on your current sitagliptin and metformin doses, blood glucose control, and kidney function. Your doctor will individualise and periodically review your dose, including checking kidney function before and during treatment.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to sitagliptin, metformin, or any ingredient in this product, or a history of a serious hypersensitivity reaction to any DPP-4 inhibitor
  • Severe kidney impairment or acute kidney injury
  • Diabetic ketoacidosis or a history of it
  • Acute or chronic metabolic acidosis
  • Conditions predisposing to tissue hypoxia (e.g. severe heart failure, respiratory failure, recent heart attack) due to lactic acidosis risk with metformin

Drug / Food Interactions

  • Iodinated contrast media used in imaging studies require metformin to be temporarily withheld due to acute kidney injury and lactic acidosis risk
  • Insulin or sulfonylureas may increase the risk of low blood sugar (hypoglycaemia) when combined – a lower dose of these medicines may be needed
  • Alcohol increases the risk of lactic acidosis with metformin and should be limited
  • Digoxin levels may be slightly increased with sitagliptin and monitoring may be advised if combined

Quick Tips

  • Take with the evening meal to reduce stomach upset and support the once-daily regimen
  • Swallow the tablet whole; never crush, split, or chew this extended-release formulation
  • Maintain good hydration, especially during illness, hot weather, or reduced food/fluid intake
  • Inform your doctor before any surgery, contrast imaging scan, or major illness, as this medicine may need to be temporarily stopped
  • Seek urgent medical attention for severe or persistent abdominal pain, or symptoms of lactic acidosis

Ingredients / Active Ingredients

  • Sitagliptin 50mg (as sitagliptin phosphate monohydrate)
  • Metformin hydrochloride (extended-release) 1000mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandMSD
ManufacturerMSD
ClassificationPrescription medicine
Ingredients / Active IngredientsMetformin
Pack Size56s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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Important Medical Information

💊 Recommended Dosage:

Janumet XR 50/1000mg Tablet is usually taken once daily with the evening meal, with the specific strength selected by your doctor based on your current sitagliptin and metformin doses, blood glucose control, and kidney function. Your doctor will individualise and periodically review your dose, including checking kidney function before and during treatment.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to sitagliptin, metformin, or any ingredient in this product, or a history of a serious hypersensitivity reaction to any DPP-4 inhibitor
  • Severe kidney impairment or acute kidney injury
  • Diabetic ketoacidosis or a history of it
  • Acute or chronic metabolic acidosis
  • Conditions predisposing to tissue hypoxia (e.g. severe heart failure, respiratory failure, recent heart attack) due to lactic acidosis risk with metformin
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.