Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)
Last updated:
Overview
Jardiance Duo 12.5/500mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Empagliflozin 12.5mg and Metformin hydrochloride 500mg as its active ingredient content.
This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.
Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.
Directions for Use
Take Jardiance Duo 12.5/500mg Tablet with meals to reduce the stomach upset that metformin can cause, swallowing the tablet whole without crushing or chewing it. Maintain adequate fluid intake, particularly during illness, hot weather, or reduced food/fluid intake, since dehydration can affect kidney function and increase the risk of side effects from both components.
Dosage
Jardiance Duo 12.5/500mg Tablet is usually taken once or twice daily depending on the specific strength prescribed, with your doctor selecting the combination and frequency based on your current empagliflozin and metformin doses, blood glucose control, and kidney function. Your doctor will individualise and periodically review your dose, including checking kidney function before and during treatment.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
Nausea or vomiting
Diarrhea
Stomach discomfort or cramps
Metallic taste in the mouth
Loss of appetite
Weight loss (in some cases)
Contraindications
Known hypersensitivity to empagliflozin, metformin, or any ingredient in this product
Severe kidney impairment or acute kidney injury
Diabetic ketoacidosis or a history of it
Acute or chronic metabolic acidosis
Conditions predisposing to tissue hypoxia (e.g. severe heart failure, respiratory failure, recent heart attack) due to lactic acidosis risk with metformin
Drug / Food Interactions
Diuretics may increase the risk of dehydration and low blood pressure when combined with empagliflozin
Iodinated contrast media used in imaging studies require metformin to be temporarily withheld due to acute kidney injury and lactic acidosis risk
Alcohol increases the risk of lactic acidosis with metformin and should be limited
Other glucose-lowering medicines (e.g. sulfonylureas, insulin) may increase the risk of low blood sugar (hypoglycaemia) when combined
Quick Tips
Take with food to reduce stomach upset from the metformin component
Maintain good hydration, especially in hot weather, during illness, or if you are eating/drinking less than usual
Practise good genital hygiene and seek prompt treatment for any signs of a genital or urinary infection
Inform your doctor before any surgery, contrast imaging scan, or major illness, as this medicine may need to be temporarily stopped
Monitor your blood glucose as advised and know the symptoms of both high and low blood sugar
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Generally Safe
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use With Care
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use With Care
Use cautiously. Liver function monitoring may be required.
Alcohol
Use With Care
Caution is advised when consuming alcohol with this medicine.
Driving
Use With Care
Use caution while driving until you know how this medicine affects you.
Frequently Asked Questions
Yes. Jardiance Duo 12.5/500mg Tablet is a prescription-only medicine (POM). It can only be supplied against a valid prescription written by a registered doctor, and it should be used only by the person named on the prescription label.
Jardiance Duo 12.5/500mg Tablet is supplied as a tablet and contains Empagliflozin 12.5mg and Metformin hydrochloride 500mg. The full composition is listed in the Composition section on this page and on the product packaging.
Malaysian rules for prescription medicines limit public product pages to product, safety and handling information. Your doctor decides whether this medicine is appropriate for you and will explain it during your consultation, and your pharmacist can answer further questions when the medicine is dispensed.
Follow your doctor’s instructions and the directions on the dispensing label without changing them. If anything on the label is unclear, check with your pharmacist before taking the first dose, and read the Directions for Use section on this page.
Take it as soon as you remember, unless your next dose is nearly due. In that case skip the missed dose and carry on with your usual schedule. Never take two doses together to make up for a missed one. If you miss doses often, tell your doctor or pharmacist.
Store below 30°C in a dry place, away from direct sunlight and out of reach of children. Keep it in the original pack until use, and do not use it after the expiry date printed on the packaging.
Tell your doctor or pharmacist about any reaction that concerns you, and seek medical care immediately for signs of a severe reaction such as difficulty breathing, swelling of the face, lips or throat, or a widespread rash. Reported reactions are listed in the Side Effects section on this page.
No. Speak to your doctor before stopping, pausing or changing the dose, even if you feel well or think you no longer need the medicine.
Customers in Malaysia can complete an online consultation with a DoctorOnCall doctor, who decides whether a prescription is appropriate, or upload a valid prescription already issued by their own doctor.
Orders going to Singapore are dispatched from Malaysia as an international delivery, so you need to hold a valid prescription or doctor’s letter for the medicine. Check the consultation and prescription upload options shown at checkout for your delivery address before placing the order.
Within Malaysia, standard delivery takes 3 to 5 working days. Same-day delivery is available in the Klang Valley for orders placed before 12pm; orders placed after 12pm arrive by the end of the next day.
Orders to Singapore are sent as international deliveries and take 5 to 9 working days. A lump-sum shipping and handling fee applies to every overseas delivery and is shown at checkout.
Customers in Malaysia can pay by FPX online banking, credit or debit card (Visa and Mastercard), and supported e-wallets including Touch ‘n Go eWallet, GrabPay and ShopeePay.
FPX and local e-wallets are tied to Malaysian bank and wallet accounts, so if your delivery address is in Singapore, use the payment options displayed at checkout for that address rather than assuming the same list applies.
Yes. DoctorOnCall ships to Singapore as an international order dispatched from Malaysia, arriving in 5 to 9 working days with a lump-sum shipping and handling fee.
Singapore’s Health Sciences Authority (HSA) allows personal imports of up to three months’ supply of a medicine for your own use or an immediate family member’s, as long as it contains no controlled drugs, psychotropic substances or prohibited items. Keep the product in its original labelled packaging and keep a copy of your prescription or doctor’s letter with it. Quantities above three months’ supply, and medicines containing controlled substances, require prior HSA approval.
Products listed on DoctorOnCall are registered with Malaysia’s Ministry of Health for supply in Malaysia, and each pack carries its MAL registration number.
An order delivered to Singapore arrives as a personal import of a Malaysia-registered product; HSA product registration is not required for personal-use quantities, but it is also not the same as a product registered for sale in Singapore. If you need a locally registered Singapore product, buy it from a pharmacy in Singapore.
DoctorOnCall’s customer care team handles order, delivery and product queries through the contact channels on the site, including WhatsApp and the online help centre.
For deliveries to Singapore, allow more time before chasing an order than you would for a local Malaysian delivery, as the parcel passes through customs clearance and tracking updates can appear later in the journey.
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Important Medical Information
💊 Recommended Dosage:
Jardiance Duo 12.5/500mg Tablet is usually taken once or twice daily depending on the specific strength prescribed, with your doctor selecting the combination and frequency based on your current empagliflozin and metformin doses, blood glucose control, and kidney function. Your doctor will individualise and periodically review your dose, including checking kidney function before and during treatment.
🛑 Contraindications (Do not use if):
Known hypersensitivity to empagliflozin, metformin, or any ingredient in this product
Severe kidney impairment or acute kidney injury
Diabetic ketoacidosis or a history of it
Acute or chronic metabolic acidosis
Conditions predisposing to tissue hypoxia (e.g. severe heart failure, respiratory failure, recent heart attack) due to lactic acidosis risk with metformin
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
Nausea or vomiting
Diarrhea
Stomach discomfort or cramps
Metallic taste in the mouth
Loss of appetite
Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
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IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.