Xigduo XR 5/1000mg Tablet
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Prescription Required
Overview
Xigduo XR 5/1000mg Tablet contains dapagliflozin and metformin hydrochloride extended-release, a combination medicine used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes.
Dapagliflozin lowers blood sugar by causing the kidneys to remove excess glucose through the urine, while metformin reduces the amount of glucose produced by the liver and improves the body’s response to insulin.
How it Works
Dapagliflozin blocks a protein in the kidney (SGLT2) responsible for reabsorbing glucose back into the blood, causing excess glucose to be excreted in the urine instead. Metformin lowers glucose production by the liver and increases the sensitivity of muscle and fat tissue to insulin, together improving overall blood sugar control.
Directions for Use
Swallow the tablet whole with the evening meal; do not crush, split, or chew it, as this affects the extended-release action.
Dosage
The dose is individualised by the treating doctor based on blood sugar control, kidney function, and any other diabetes medicines being used, generally taken once daily with the evening meal.
Shelf Life
Refer to the expiry date printed on the packaging.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea or vomiting
- Diarrhea
- Stomach discomfort or cramps
- Metallic taste in the mouth
- Loss of appetite
- Weight loss (in some cases)
Contraindications
- Known hypersensitivity to dapagliflozin, metformin, or any ingredient in the tablet
- Severe kidney impairment
- Type 1 diabetes or diabetic ketoacidosis
- Severe liver disease or conditions that increase the risk of lactic acidosis
Drug / Food Interactions
- Iodinated contrast dye used in some imaging scans can affect kidney function – metformin may need to be paused around the time of the scan.
- Diuretics (‘water pills’) can increase the risk of dehydration and low blood pressure when combined with dapagliflozin.
- Other diabetes medicines, particularly insulin and sulfonylureas, can increase the risk of low blood sugar when combined.
- Excess alcohol intake can increase the risk of lactic acidosis with metformin – avoid heavy or binge drinking.
Quick Tips
- Drink adequate fluids, as dapagliflozin increases urination and fluid loss.
- Practise good genital hygiene to help reduce the risk of yeast infections associated with this medicine.
- Tell your doctor if you are scheduled for surgery or an imaging scan using contrast dye, as this medicine may need to be paused.
- Watch for signs of low blood sugar (shakiness, sweating, confusion) if combined with insulin or sulfonylureas.
Frequently Asked Questions
What is Xigduo XR used for?
Xigduo XR combines dapagliflozin and extended-release metformin to improve blood sugar control in adults with type 2 diabetes.
How do the two medicines in Xigduo XR work together?
Dapagliflozin causes the kidneys to remove excess sugar through urine, while metformin reduces the liver’s sugar production and improves insulin sensitivity.
Why do I need to take this medicine with food?
Taking it with the evening meal helps reduce stomach upset and supports steady absorption of the extended-release metformin component.
Can I crush or split the tablet?
No, crushing or splitting the tablet can affect how the extended-release metformin component is absorbed – swallow it whole.
Why does this medicine increase my risk of genital yeast infections?
Because dapagliflozin causes extra sugar to be passed in the urine, which can encourage yeast growth in the genital area – good hygiene helps reduce this risk.
Can I drink alcohol while taking this medicine?
Avoid heavy or binge drinking, as excess alcohol combined with metformin can increase the risk of a rare but serious condition called lactic acidosis.
Do I need to stop this medicine before a scan with contrast dye?
Yes, tell your doctor about any planned imaging scan using contrast dye, as metformin may need to be temporarily paused.
Can I buy Xigduo XR 5/1000mg Tablet from DoctorOnCall?
Yes, Xigduo XR 5/1000mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Xigduo XR 5/1000mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Xigduo XR 5/1000mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Xigduo XR 5/1000mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Xigduo XR 5/1000mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Xigduo XR 5/1000mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Dapagliflozin (as dapagliflozin propanediol monohydrate)
- Metformin hydrochloride extended-release 5/1000mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
