Glucophage XR 500mg Tablet 15s (strip)

Glucophage XR 500mg is an extended-release oral tablet belonging to the biguanide class of antidiabetic medications, with Metformin Hydrochloride as its active ingredient. This medicine is widely trusted by healthcare professionals and is one of the most commonly prescribed tablets in its category across the globe, including Malaysia. Like most medicines, it may cause some side effects in certain individuals — the more commonly reported ones include nausea, diarrhoea, stomach upset, and a metallic taste in the mouth, though these often settle as your body adjusts. If you are wondering whether this tablet is right for you, how often you should take it, or whether you need a prescription to get it — you are in the right place, and we want to make sure you have all the information you need to feel confident and safe. Always speak to your doctor or pharmacist before starting or changing any medication. 

How to Take Glucophage XR 500mg Tablet
Glucophage XR 500mg tablets should be taken orally with a full glass of water, ideally with your evening meal or as directed by your doctor, to help reduce the chance of stomach discomfort. Because this is an extended-release formulation, the tablet must be swallowed whole — do not crush, chew, or break it, as doing so may affect how the medicine is released into your body. Always follow your prescribing doctor's instructions regarding timing and frequency, as individual needs may vary.

Dosage of Glucophage XR 500mg Tablet
The typical starting dose for adults is 500mg once daily with the evening meal, which may be gradually increased by your doctor up to a maximum of 2000mg per day, depending on your individual response and tolerance. Your doctor will determine the most suitable dose for you, so it is important not to self-adjust your dosage without professional medical advice.

Shelf Life of Glucophage XR 500mg Tablet
Glucophage XR 500mg tablets generally have a shelf life of 3 years from the date of manufacture, as indicated on the packaging. Always check the expiry date printed on the box or blister pack before use and do not take the tablet if it has passed its expiry date. Expired medicines should be disposed of safely and responsibly — do not flush them down the drain or throw them in regular household waste. Contact your local pharmacy for guidance on proper medicine disposal in Malaysia.

How to Store Glucophage XR 500mg Tablet

• Store Glucophage XR 500mg tablets at room temperature, below 25°C
• Keep the tablets in a cool, dry place, away from direct sunlight and moisture
• Do not store in the bathroom, near a sink, or in areas with high humidity
• Keep the medicine in its original packaging with the lid tightly closed
• Store out of reach and sight of children at all times
• Do not use the tablet if the packaging appears damaged, tampered with, or compromised

Active Ingredient of Glucophage XR 500mg Tablet

Side Effects of Glucophage XR 500mg Tablet
It is important to be aware of potential side effects before taking any medication. Below are the known side effects associated with Glucophage XR 500mg:

Common Side Effects:

• Nausea and vomiting
• Diarrhoea or loose stools
• Stomach pain or abdominal discomfort
• Loss of appetite
• Metallic or unpleasant taste in the mouth
• Flatulence (gas) or bloating
• Indigestion or heartburn

Less Common Side Effects:

• Headache or dizziness
• Weakness or general fatigue
• Skin rash or itching (hypersensitivity reactions)
• Decreased absorption of Vitamin B12 with long-term use
• Low blood sugar (hypoglycaemia) — more likely when combined with other antidiabetic medicines

Rare but Serious Side Effects (Seek Immediate Medical Attention):

• Lactic acidosis — a rare but potentially life-threatening condition characterised by muscle pain, difficulty breathing, stomach discomfort, dizziness, and irregular heartbeat
• Severe allergic reactions including swelling of the face, lips, or throat
• Unusual tiredness or persistent weakness that does not improve

⚠️ If you experience any serious or unexpected side effects, stop taking the medication and consult your doctor or visit the nearest healthcare facility immediately.

Contraindications of Glucophage XR 500mg Tablet
Glucophage XR 500mg should not be used in the following situations:

• Allergy or hypersensitivity to Metformin Hydrochloride or any component of the tablet
• Renal impairment or kidney disease — particularly in patients with an eGFR below 30 mL/min/1.73m²
• Hepatic impairment or severe liver disease
• Diabetic ketoacidosis or diabetic pre-coma
• Acute or chronic conditions that may cause dehydration, such as severe infection, shock, or excessive fluid loss
• Congestive heart failure or conditions requiring drug treatment that may affect kidney function
• Respiratory failure or conditions associated with hypoxia (low oxygen levels)
• Recent myocardial infarction (heart attack) or other serious cardiovascular events
• Excessive alcohol consumption or chronic alcoholism
• Pregnancy — use only if clearly indicated and under strict medical supervision
• Patients scheduled for iodinated contrast imaging procedures — Metformin should be temporarily discontinued before and after the procedure as advised by the doctor
• Children under 10 years of age — safety and efficacy have not been established

📌 Always inform your doctor about your full medical history, existing conditions, and all medications you are currently taking before starting Glucophage XR.

Drug & Food Interaction of Glucophage XR 500mg Tablet

Drug Interactions:

• Iodinated contrast agents — may increase the risk of lactic acidosis; Metformin should be paused before contrast-based imaging procedures
• Alcohol — increases the risk of lactic acidosis and may cause unpredictable changes in blood sugar levels
• Other antidiabetic medicines (e.g., insulin, sulphonylureas) — may increase the risk of hypoglycaemia (low blood sugar) when used together
• Corticosteroids (e.g., prednisolone) — may reduce the blood sugar-lowering effect of Metformin
• Diuretics (water tablets) — particularly loop diuretics, may increase the risk of renal impairment and lactic acidosis
• ACE inhibitors and ARBs — may affect kidney function and alter the effectiveness of Metformin
• Cimetidine — may increase Metformin plasma levels by competing for renal tubular secretion
• Beta-blockers — may mask symptoms of low blood sugar (e.g., trembling, rapid heartbeat)
• NSAIDs (e.g., ibuprofen, naproxen) — regular use may affect kidney function and increase the risk of adverse effects

Food Interactions:

• Alcohol — should be avoided or strictly limited, as it significantly increases the risk of lactic acidosis
• Taking Glucophage XR with a heavy, high-fat meal may alter the absorption profile — always follow your doctor's specific dietary advice
• A low-carbohydrate or very restricted diet without medical guidance may increase the risk of hypoglycaemia, especially when combined with other medications

💬 Always inform your doctor and pharmacist about every medicine, supplement, or herbal product you are taking to avoid potential interactions.

Quick Tips for Glucophage XR 500mg Tablet

• Always take this tablet with your evening meal to reduce the likelihood of stomach-related side effects
• Swallow the tablet whole — never crush, split, or chew it, as it is an extended-release formulation
• Do not skip doses, but if you miss one, take it as soon as you remember — unless it is almost time for your next dose; never double up
• Stay well hydrated throughout the day, especially during hot weather or if you are unwell
• Avoid alcohol while taking this medication to reduce the risk of serious side effects
• Inform your doctor or dentist that you are taking Metformin before any surgical procedure or medical imaging involving contrast dye
• Store the tablets properly — in a cool, dry place below 25°C, away from sunlight and moisture
• Check the expiry date on the packaging before taking each tablet
• Do not share your medication with others, even if they appear to have similar symptoms
• Keep all follow-up appointments with your doctor to monitor your response to the medication and check kidney function periodically
• Purchase only from licensed and verified pharmacies — whether online or in-store — to ensure you receive genuine, properly stored medication
• Keep this medicine out of reach of children at all times

FAQs – Glucophage XR 500mg Tablet

Q1: Can I buy Glucophage XR 500mg online in Malaysia?
Yes, you can purchase Glucophage XR 500mg through our licensed online pharmacy in Malaysia. We are committed to providing genuine, pharmacy-grade medications with a safe and straightforward ordering process — all from the comfort of your home.

Q2: Do I need a prescription to order Glucophage XR 500mg in Malaysia?
Yes, Glucophage XR 500mg is a prescription-only medication (POM) in Malaysia. You will be required to provide a valid prescription from a registered medical practitioner when placing your order. This is in place to protect your health and ensure the medicine is appropriate for you.

Q3: How do I submit my prescription when ordering online?
It is simple and convenient. After adding the product to your cart, you can upload a clear photo or scanned copy of your prescription during the checkout process. Our pharmacist team will review and verify it before processing your order. If you have any questions, our customer support team is always happy to help.

Q4: How can I be sure that the Glucophage XR I receive is genuine and not counterfeit?
We source all our medications directly from authorised distributors and licensed pharmaceutical suppliers in Malaysia. Every product we carry is stored and handled in accordance with pharmaceutical standards. You can also verify product authenticity by checking the batch number and manufacturer details on the packaging upon receipt.

Q5: How long does delivery take within Malaysia?
We offer delivery across Peninsular Malaysia and East Malaysia (Sabah & Sarawak). Standard delivery typically takes 2 to 5 working days, while expedited options may be available depending on your location. You will receive a tracking number once your order has been dispatched so you can monitor your delivery in real time.

Q6: Is it safe to order medicine online from your pharmacy in Malaysia?
Absolutely. Our online pharmacy operates in compliance with Malaysian pharmaceutical regulations. We prioritise patient safety, data privacy, and medication authenticity in every order. Our team includes qualified pharmacists who oversee the dispensing process to ensure you receive the correct and genuine product.

Q7: What should I do if my Glucophage XR tablets arrive damaged or appear tampered with?
Please do not take the medication if the packaging appears damaged, unsealed, or tampered with. Contact our customer service team immediately with photos of the product and packaging. We will arrange for a replacement or refund in accordance with our returns and quality assurance policy.

Q8: Can I order Glucophage XR 500mg in bulk or for a 3-month supply?
Yes, subject to your prescription coverage, we can fulfil orders for longer supply periods. Please ensure your prescription reflects the quantity required. For larger orders or recurring prescriptions, feel free to contact our pharmacist team directly for assistance.

Q9: How will my order be packaged for delivery?
All orders are packaged in discreet, secure packaging to protect the integrity of the medication during transit. Temperature-sensitive medicines are handled with appropriate packaging to maintain quality throughout the delivery process.

Q10: What payment methods are accepted for online orders in Malaysia?
We accept a range of secure payment options including online banking (FPX), major credit and debit cards, and selected e-wallet platforms available in Malaysia. All transactions are processed through a secure payment gateway to protect your financial information.

Q11: Can I get a refund if I change my mind after ordering?
Due to the nature of pharmaceutical products and patient safety regulations, returns and refunds are subject to our pharmacy's return policy. Generally, unopened and undamaged products may be eligible for review on a case-by-case basis. Please contact our support team within the stipulated timeframe for assistance.

Q12: How do I know if the price listed on your website is accurate and up to date?
All product prices on our website are regularly reviewed and updated to reflect current market pricing in Malaysia. The price displayed at checkout is the final price, inclusive of any applicable taxes. We strive to offer competitive and transparent pricing with no hidden charges.