Twynsta 40/5mg Tablet
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Overview
Twynsta 40/5mgmg Tablet is a fixed-dose combination of telmisartan, an angiotensin II receptor blocker (ARB), and amlodipine, a calcium channel blocker, used to treat high blood pressure (hypertension) in adults whose blood pressure is not adequately controlled on either medicine alone.
The two medicines lower blood pressure through complementary mechanisms: telmisartan blocks a hormone that narrows blood vessels, while amlodipine relaxes and widens blood vessel walls directly.
How it Works
Telmisartan blocks angiotensin II from binding to its receptor, preventing blood vessel narrowing and reducing sodium and fluid retention. Amlodipine blocks calcium entry into the smooth muscle cells of blood vessel walls, causing them to relax and widen. Together, these actions lower blood pressure more effectively than either medicine alone.
Directions for Use
Take the tablet once daily at the same time each day, with or without food, swallowed whole with water.
Dosage
The usual dose is one 40/5mgmg tablet taken once daily. Your doctor will determine the appropriate strength based on your blood pressure response and any other medicines you are taking.
Shelf Life
Refer to the expiry date printed on the packaging.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Dizziness or lightheadedness
- Swelling of the ankles or feet
- Fatigue
- Flushing (warmth or redness in face/skin)
- Nausea
Contraindications
- Known hypersensitivity to telmisartan, amlodipine, dihydropyridine calcium channel blockers, or any excipient
- Pregnancy and breastfeeding
- Severe liver impairment or bile duct obstruction
- Severe low blood pressure or cardiogenic shock
- Concurrent use with aliskiren-containing medicines in patients with diabetes or kidney impairment
Drug / Food Interactions
- NSAIDs (such as ibuprofen) may reduce the blood pressure-lowering effect and increase the risk of kidney problems.
- Potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase blood potassium levels when combined with telmisartan.
- Grapefruit juice may increase amlodipine levels and should be used cautiously.
- Inform your doctor of all medicines you are taking, including other blood pressure medicines.
Quick Tips
- Rise slowly from sitting or lying positions, especially when starting treatment, to reduce dizziness.
- Monitor your blood pressure regularly as advised by your doctor.
- Report new or worsening ankle swelling to your doctor.
- Do not stop this medicine suddenly without consulting your doctor.
Frequently Asked Questions
What is Twynsta used for?
Twynsta is a combination of telmisartan and amlodipine used to treat high blood pressure that is not adequately controlled by either medicine alone.
How does Twynsta lower blood pressure?
Telmisartan blocks a hormone that narrows blood vessels, while amlodipine relaxes blood vessel walls directly – together they lower blood pressure more effectively.
Can I stop taking this medicine once my blood pressure is normal?
No, high blood pressure treatment is usually long-term – stopping suddenly can cause your blood pressure to rise again. Only adjust treatment under your doctor’s guidance.
Why do my ankles feel swollen on this medicine?
Ankle swelling is a recognised side effect of amlodipine; mention it to your doctor if it is bothersome or worsening.
Can I take this medicine if I am pregnant?
No, this medicine is not safe during pregnancy as it can harm the developing baby – inform your doctor immediately if you become pregnant.
Can I take NSAID painkillers like ibuprofen with this medicine?
Use caution – NSAIDs can reduce the blood pressure-lowering effect and increase the risk of kidney problems, especially with regular use.
Should I avoid grapefruit juice while taking this medicine?
It is best to limit grapefruit juice, as it may increase amlodipine levels in your blood.
Can I buy Twynsta 40/5mg Tablet from DoctorOnCall?
Yes, Twynsta 40/5mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Twynsta 40/5mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Twynsta 40/5mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Twynsta 40/5mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Twynsta 40/5mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Twynsta 40/5mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Telmisartan 40mg
- Amlodipine 5mgmg (as amlodipine besylate)
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Generally safe, but caution may be required in some patients.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
