Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)
Last updated:
Key Information
What is Upha Glucoxit 500mg Tablet?
Upha Glucoxit 500mg Tablet contains metformin hydrochloride 500mg per tablet, an oral medicine belonging to the biguanide class.
Metformin affects how the body handles glucose and responds to insulin. Its effects and suitability vary according to an individual's medical condition and treatment plan.
The tablet is manufactured by Duopharma and is listed on DoctorOnCall Malaysia in a 10-tablet pack.
Check the product packaging and accompanying leaflet for the active ingredient, strength, registration details and instructions. Consult your pharmacist or doctor if any information is unclear.
Is this strength right for me?
Upha Glucoxit is available in a 500mg tablet strength. The appropriate dose depends on your individual circumstances, kidney function, other medicines and the directions provided by your treating healthcare professional.
The tablet is generally taken with or immediately after meals, according to the directions provided by your healthcare professional. Swallow it with water and follow the product-specific instructions.
Do not start taking metformin without confirming that it is appropriate for you, particularly if you have kidney or liver problems, a history of metabolic acidosis, severe heart problems or a condition that may cause dehydration.
Tell your pharmacist or doctor if you are pregnant, planning a pregnancy or breastfeeding, or if you have any allergies or ongoing medical conditions.
If you are unsure whether this strength or product is appropriate for you, seek advice from our pharmacist or doctor before placing an order.
Delivery, packaging and ordering
Select Upha Glucoxit 500mg Tablet and the available pack size on DoctorOnCall Malaysia, then review the product details before proceeding with your order.
If you need clarification about the product, your current medicines or the directions provided by your healthcare professional, contact a pharmacist before ordering.
DoctorOnCall lists delivery options for this product. Delivery availability and charges depend on your location and the applicable order and delivery terms.
Orders are subject to the pharmacy's applicable dispensing and verification procedures. Confirm the product's current supply classification with the pharmacy before publication of any statement about prescription requirements.
When your parcel arrives, check the product name, strength, packaging integrity, batch details and expiry date before taking the tablets.
Side effects, safety and when to seek help
Possible side effects of metformin include nausea, vomiting, diarrhoea, abdominal discomfort and changes in taste. These effects may vary between individuals and can be more noticeable when treatment begins.
Taking the tablet with meals, when directed, may help reduce gastrointestinal discomfort. Contact your pharmacist or doctor if side effects persist or interfere with your daily activities.
Metformin can rarely cause a serious condition called lactic acidosis, in which lactic acid builds up in the blood. The risk is higher in certain circumstances, including severe kidney impairment, dehydration, serious infection and excessive alcohol consumption.
Seek emergency medical attention if you experience unusual muscle cramps, severe weakness or tiredness, abdominal pain with vomiting, or difficulty breathing, particularly if several symptoms occur together.
How to take your Upha Glucoxit Tablet
Check the instructions. Read the package leaflet and confirm your directions with your pharmacist or doctor. Make sure they know about your medical conditions, allergies and other medicines.
Follow the recommended directions. Take the tablet according to the instructions provided by your treating healthcare professional. Do not change the amount or timing on your own.
Take with food when directed. Metformin is commonly taken with or immediately after meals to reduce stomach discomfort. Swallow the tablet with water and follow the product-specific instructions.
Monitor your condition. Attend recommended appointments for kidney-function checks and other monitoring. If you become seriously unwell or develop symptoms that may indicate lactic acidosis, seek urgent medical assessment.
Delivery & Returns
Malaysia-wide delivery
No prescription needed
Licensed pharmacy
Doctor consultation
If your order arrives damaged
Do not take Upha Glucoxit 500mg Tablet if the packaging is damaged, the blister strip is torn or opened, or the product appears to have been tampered with.
Check the carton and blister strip for signs of damage before taking the tablets.
Contact us on WhatsApp promptly and provide photographs of the outer packaging and affected product.
We will review the issue and arrange a replacement at no extra cost if the delivery issue is verified, in accordance with the applicable returns policy.
Returns policy
For safety and medicine-handling reasons, Upha Glucoxit 500mg Tablet cannot be returned or exchanged once it has left our pharmacy, except in cases involving a verified delivery issue, such as damaged packaging, an incorrect item or a missing item.
If there is a problem with your order, contact us within 24 hours of delivery so we can review the issue and advise you on the next steps.
Dosage is individualised by the prescribing doctor based on blood sugar control, kidney function, and response to treatment, usually starting at a low dose and gradually increased to reduce gastrointestinal side effects. This medicine requires a valid prescription obtained through an online consultation with a doctor via DoctorOnCall, and should never be self-adjusted or shared with another person.
Shelf Life
Upha Glucoxit 500mg Tablet is generally stable for up to 36 months from the date of manufacture when stored correctly and left unopened. Always check the expiry date printed on the blister strip or carton before use and do not use expired tablets.
Storage Instructions
Do
Store the tablets in a dry place below 30°C.
Protect the product from light and keep it in its original packaging.
Keep the tablets out of reach of children.
Check the expiry date and batch details on the packaging.
Follow any additional storage instructions printed on the carton or leaflet.
Don't
Don’t expose the tablets to excessive heat or moisture.
Don’t transfer tablets into unlabelled containers.
Don’t take the tablets after the expiry date.
Don’t share your medicine with another person.
Don’t dispose of unwanted tablets in household drains. Ask your pharmacist about appropriate medicine disposal.
Side Effects
Upha Glucoxit 500mg Tablet may cause digestive symptoms and other reactions in some people. These effects may vary between individuals, and some may require medical assessment, particularly during long-term treatment or in people with underlying health conditions.
Nausea and Vomiting
Nausea, vomiting or stomach discomfort may occur, particularly when treatment is first started.
Diarrhoea
Loose stools or diarrhoea may occur, especially during the initial stages of treatment.
Loss of Appetite
Some people may notice a reduced appetite or less interest in food.
Metallic Taste
A metallic taste in the mouth may develop during treatment.
Vitamin B12 Deficiency
Long-term use of metformin may reduce vitamin B12 levels. A deficiency may contribute to tiredness, anaemia or tingling and numbness, and monitoring may be appropriate for some patients.
Serious Warning: Lactic Acidosis
Lactic acidosis is a rare but potentially life-threatening complication associated with metformin. The risk may be higher in people with significant kidney impairment and certain conditions affecting liver function or causing reduced oxygen supply to the body.
Seek emergency medical attention if you experience warning signs such as:
Severe or unusual weakness.
Difficulty breathing or unusually deep, rapid breathing.
Persistent vomiting or abdominal pain accompanied by feeling very unwell.
Unusual drowsiness, dizziness or feeling cold with worsening symptoms.
If lactic acidosis is suspected, seek emergency care immediately rather than waiting for symptoms to improve.
This information does not replace the product leaflet or advice from a healthcare professional. Consult your doctor if side effects persist, worsen or cause concern. Do not change your dose or stop treatment without appropriate medical advice.
Contraindications
Severe kidney impairment or significantly reduced kidney function
Acute or unstable conditions that may affect kidney function, such as severe dehydration or shock
Known hypersensitivity to metformin
Severe liver disease
Conditions causing tissue hypoxia, such as severe heart or respiratory failure
Should be temporarily stopped before procedures involving iodinated contrast dye, as advised by a doctor
Drug / Food Interactions
Alcohol should be avoided or limited, as it increases the risk of lactic acidosis and low blood sugar
Certain diuretics, corticosteroids, and other medicines that raise blood sugar may reduce metformin’s effectiveness
Iodinated contrast media used in some imaging procedures may temporarily affect kidney function and increase lactic acidosis risk
Other diabetes medicines or insulin may increase the risk of low blood sugar when combined
Certain medicines that affect kidney elimination, such as some antibiotics, may alter metformin levels in the body
Quick Tips
Take this medicine exactly as prescribed and attend all scheduled follow-up appointments for blood sugar and kidney function monitoring
Take with food to reduce stomach upset, especially when starting treatment
Inform your doctor before any surgery, contrast dye imaging scan, or if you become severely unwell or dehydrated
Watch for signs of lactic acidosis such as unusual muscle pain, difficulty breathing, or severe tiredness, and seek urgent medical attention if these occur
Continue diet and lifestyle measures recommended by your doctor alongside this medicine for best blood sugar control
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Generally Safe
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use With Care
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use With Care
Use cautiously. Liver function monitoring may be required.
Alcohol
Use With Care
Caution is advised when consuming alcohol with this medicine.
Driving
Use With Care
Use caution while driving until you know how this medicine affects you.
Relevant Information
Metformin remains one of the most established and widely prescribed first-line treatments for type 2 diabetes worldwide, valued for its effectiveness and low risk of causing hypoglycaemia when used alone. Because ongoing kidney function monitoring and periodic review of blood sugar control are essential, Upha Glucoxit is dispensed by DoctorOnCall only after a doctor’s assessment, with regular follow-up recommended throughout treatment for patients in Malaysia and Singapore.
How to buy
Go to the DoctorOnCall website
Visit DoctorOnCall Malaysia, search for Upha Glucoxit 500mg Tablet and select the available pack size.
Place your order
Review the product details, enter your delivery information and proceed through the available checkout and payment options. Confirm any applicable dispensing requirements with the pharmacy before completing your order.
Pharmacist review and dispensing
The pharmacy reviews the order and confirms the applicable dispensing requirements before preparing it. A registered pharmacist can clarify product information, directions and relevant safety precautions.
Receive your order
Your order is packed for delivery to your address. Delivery options and timing depend on your location and the applicable delivery terms. Check the packaging, tablet strength and expiry date when the parcel arrives before taking the tablets.
Frequently Asked Questions
No. Upha Glucoxit 500mg Tablet is a non-prescription product and can be ordered without a prescription. It is still dispensed by a registered pharmacist on DoctorOnCall.
Upha Glucoxit 500mg Tablet is a tablet containing Metformin hydrochloride 500mg. The full ingredient list is shown in the Composition or Ingredients section on this page and on the product packaging.
It is supplied in a pack size of 10s. Choose the pack size you need from the options shown on this page before adding the item to your cart.
This page is limited to product, safety and handling information in line with Malaysian rules on medicine information. If you want advice on whether this product suits you, book an online consultation with a doctor or pharmacist on DoctorOnCall.
Follow the instructions printed on the label and in the leaflet supplied with the pack, and do not exceed the stated amount or duration. Handling steps are set out in the Directions for Use section on this page.
Yes. DoctorOnCall offers online consultations with licensed doctors and registered pharmacists, so you can ask about this product, your existing medicines, or anything on the label before you place an order.
Store below 30°C in a cool, dry place away from direct sunlight and moisture. Keep tablets in their original packaging until ready for use, and keep out of reach of children. Keep it in its original pack and do not use it after the expiry date printed on the packaging.
Stop using the product and speak to a doctor or pharmacist about any reaction that concerns you. Seek medical care immediately for signs of a severe reaction such as difficulty breathing, swelling of the face, lips or throat, or a widespread rash. Reported reactions are listed in the Side Effects section on this page.
Within Malaysia, standard delivery takes 3 to 5 working days. Same-day delivery is available in the Klang Valley for orders placed before 12pm; orders placed after 12pm arrive by the end of the next day.
Orders to Singapore are sent as international deliveries and take 5 to 9 working days. A lump-sum shipping and handling fee applies to every overseas delivery and is shown at checkout.
Customers in Malaysia can pay by FPX online banking, credit or debit card (Visa and Mastercard), and supported e-wallets including Touch ‘n Go eWallet, GrabPay and ShopeePay.
FPX and local e-wallets are tied to Malaysian bank and wallet accounts, so if your delivery address is in Singapore, use the payment options displayed at checkout for that address rather than assuming the same list applies.
Yes. DoctorOnCall ships to Singapore as an international order dispatched from Malaysia, arriving in 5 to 9 working days with a lump-sum shipping and handling fee.
Singapore’s Health Sciences Authority (HSA) allows personal imports of up to three months’ supply of a medicine for your own use or an immediate family member’s, as long as it contains no controlled drugs, psychotropic substances or prohibited items. Keep the product in its original labelled packaging and keep a copy of your prescription or doctor’s letter with it. Quantities above three months’ supply, and medicines containing controlled substances, require prior HSA approval.
Products listed on DoctorOnCall are registered with Malaysia’s Ministry of Health for supply in Malaysia, and each pack carries its MAL registration number.
An order delivered to Singapore arrives as a personal import of a Malaysia-registered product; HSA product registration is not required for personal-use quantities, but it is also not the same as a product registered for sale in Singapore. If you need a locally registered Singapore product, buy it from a pharmacy in Singapore.
DoctorOnCall’s customer care team handles order, delivery and product queries through the contact channels on the site, including WhatsApp and the online help centre.
For deliveries to Singapore, allow more time before chasing an order than you would for a local Malaysian delivery, as the parcel passes through customs clearance and tracking updates can appear later in the journey.
Product Specifications
Brand
Upha Glucoxit
Classification
Non-prescription
Ingredients / Active Ingredients
Metformin
Pack Size
10s
Manufacturer
Duopharma (M) Sdn. Bhd.
Strength
500mg per tablet
Dosage
Refer to the product packaging and package leaflet for directions on use.
Shelf Life
Refer to the expiry date printed on the blister strip or carton. Confirm the manufacturer's stated shelf-life period from the current product packaging.
Pack Contents
10 tablets, subject to the selected pack option
Registration Holder
Duopharma (M) Sdn. Bhd.
Form
Tablet
Route
Oral
Storage
Store in a dry place below 30°C, protect from light and keep out of reach of children.
Excipients
Povidone, microcrystalline cellulose, magnesium stearate and hypromellose film coating, according to available product information. Refer to the current package insert for the complete formulation.
What condition or symptom are you treating with this medication?
Please select your condition / symptom before adding to cart.
*Please select the closest match. A pharmacist may call to verify your selection before dispensing.
Important Medical Information
💊 Recommended Dosage:
Dosage is individualised by the prescribing doctor based on blood sugar control, kidney function, and response to treatment, usually starting at a low dose and gradually increased to reduce gastrointestinal side effects. This medicine requires a valid prescription obtained through an online consultation with a doctor via DoctorOnCall, and should never be self-adjusted or shared with another person.
🛑 Contraindications (Do not use if):
Severe kidney impairment or significantly reduced kidney function
Acute or unstable conditions that may affect kidney function, such as severe dehydration or shock
Known hypersensitivity to metformin
Severe liver disease
Conditions causing tissue hypoxia, such as severe heart or respiratory failure
Should be temporarily stopped before procedures involving iodinated contrast dye, as advised by a doctor
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
Nausea or vomiting
Diarrhea
Stomach discomfort or cramps
Metallic taste in the mouth
Loss of appetite
Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
Please tick this box to confirm you are 18+ before adding to cart.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.