Celebrex 400mg Capsule
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Prescription Required
Overview
Celebrex 400mg Capsule contains celecoxib 400mg, a COX-2 selective non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain. Celebrex is the original branded formulation of celecoxib, developed by Pfizer.
Celecoxib works by selectively blocking the COX-2 enzyme, which is primarily responsible for producing the prostaglandins that drive pain, swelling, and inflammation, while having comparatively less effect on the COX-1 enzyme that helps protect the stomach lining.
How it Works
Celecoxib selectively inhibits cyclo-oxygenase-2 (COX-2), an enzyme that is upregulated at sites of inflammation and produces prostaglandins responsible for pain, swelling, and fever. By reducing prostaglandin production at these sites, celecoxib relieves pain and inflammation, with relatively less suppression of the COX-1 enzyme that maintains protective prostaglandins in the stomach lining compared to non-selective NSAIDs.
Directions for Use
Take Celebrex 400mg Capsule with or without food, though taking it with food or milk may help reduce stomach upset. Swallow the capsule whole with a glass of water; do not open or crush it. Take it at about the same time each day if prescribed for regular, ongoing use.
Dosage
The usual dose of Celebrex 400mg Capsule depends on the condition being treated – for example, 200mg once daily or 100mg twice daily for osteoarthritis, 100-200mg twice daily for rheumatoid arthritis, or an initial higher dose followed by 200mg twice daily as needed for acute pain. Your doctor will determine the dose and duration appropriate for your condition, and the lowest effective dose for the shortest necessary duration is generally recommended.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Indigestion or stomach discomfort
- Diarrhoea
- High blood pressure
- Swelling in hands or feet
- Dizziness
- Skin rash
Contraindications
- Known hypersensitivity to celecoxib, sulfonamides, or any ingredient in this product
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active peptic ulcer disease or gastrointestinal bleeding
- Severe heart failure or use for pain right after coronary artery bypass graft (CABG) surgery
- Third trimester of pregnancy
Drug / Food Interactions
- Warfarin and other anticoagulants may have an increased bleeding effect when combined with celecoxib
- ACE inhibitors or ARBs (blood pressure medicines) may have reduced effectiveness and kidney function may be affected
- Fluconazole significantly increases celecoxib blood levels and the dose may need adjustment
- Lithium levels may increase, requiring closer monitoring
- Other NSAIDs or aspirin should generally not be combined with celecoxib
Quick Tips
- Take with food if you experience stomach upset
- Do not combine with other NSAIDs or over-the-counter pain relievers without asking your pharmacist
- Report unusual bruising, black stools, or persistent stomach pain to your doctor promptly
- Stay well hydrated, especially in hot weather or with reduced fluid intake
Frequently Asked Questions
What is Celebrex 400mg Capsule used for?
Celebrex 400mg Capsule is used to relieve pain, swelling, and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other painful inflammatory conditions, as determined by your doctor.
Is celecoxib gentler on the stomach than other NSAIDs?
Celecoxib is designed to selectively target the COX-2 enzyme involved in inflammation, which generally causes less stomach irritation than non-selective NSAIDs, though the risk of stomach upset or bleeding is not eliminated and caution is still needed, especially with long-term use.
Can I take celecoxib if I have a heart condition?
Celecoxib and other NSAIDs can increase cardiovascular risk, particularly with long-term use or in people with existing heart disease. Always inform your doctor about any heart conditions before starting this medicine.
How long can I take Celebrex 400mg Capsule?
Duration depends on your condition – your doctor will advise how long to continue treatment, generally using the lowest effective dose for the shortest period needed to control your symptoms.
What should I do if I miss a dose of Celebrex 400mg Capsule?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Celebrex 400mg Capsule from DoctorOnCall?
Yes, Celebrex 400mg Capsule is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Celebrex 400mg Capsule according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Celebrex 400mg Capsule?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Celebrex 400mg Capsule cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Celebrex 400mg Capsule?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Celebrex 400mg Capsule?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Celecoxib 400mg
Safety Advice
Pregnancy
Use during pregnancy is generally not recommended unless absolutely necessary.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
