CoAprovel 150/12.5mg Tablet

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Manufacturer Sanofi
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Overview

CoAprovel 150/12.5mg Tablet is a prescription-only medicine (POM) that contains Irbesartan 150mg and Hydrochlorothiazide 12.5mg. It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, CoAprovel 150/12.5mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take CoAprovel 150/12.5mg Tablet at about the same time each day, with or without food, and swallow the tablet whole with a glass of water. Do not stop taking this medicine suddenly without consulting your doctor, as blood pressure control needs to be continuous even once you feel well.

Dosage

The usual dose of CoAprovel 150/12.5mg Tablet is one tablet once daily. Your doctor will determine whether this combination dose is appropriate for you based on your response to irbesartan or hydrochlorothiazide monotherapy, and may adjust the dose depending on your blood pressure control and kidney function. Always take exactly as prescribed.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or lightheadedness, especially when standing up
  • Fatigue or tiredness
  • Nausea
  • Headache
  • High potassium levels (may show as muscle weakness or irregular heartbeat)
  • Back pain

Contraindications

  • Known hypersensitivity to irbesartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any ingredient in this product
  • Anuria (inability to produce urine) or severe kidney impairment
  • Pregnancy (can cause harm to the developing baby, especially in the second and third trimester)
  • Severe liver impairment
  • Concomitant use with aliskiren in patients with diabetes or kidney impairment

Drug / Food Interactions

  • Potassium supplements or potassium-sparing diuretics may raise the risk of high blood potassium
  • NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function
  • Lithium levels may increase when combined with this medicine
  • Alcohol, barbiturates, or narcotics may worsen dizziness from low blood pressure on standing

Quick Tips

  • Take at the same time each day to build a consistent routine
  • Monitor your blood pressure regularly as advised by your doctor
  • Rise slowly from sitting or lying down to reduce dizziness
  • Attend scheduled blood tests to check kidney function and electrolyte levels

Ingredients / Active Ingredients

  • Irbesartan 150mg
  • Hydrochlorothiazide 12.5mg

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandSanofi-Aventis
ManufacturerSanofi
ClassificationPrescription medicine
Ingredients / Active IngredientsIrbesartan
Pack Size14s, 28s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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