CoAprovel 150/12.5mg Tablet
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Overview
CoAprovel 150/12.5mg Tablet is a fixed-dose combination tablet containing irbesartan 150mg, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide 12.5mg, a thiazide diuretic. It is used to treat high blood pressure (hypertension) in patients whose blood pressure is not adequately controlled on either medicine alone.
Irbesartan works by blocking angiotensin II, a hormone that narrows blood vessels, allowing the vessels to relax and widen. Hydrochlorothiazide works separately by helping the kidneys remove excess salt and water from the body. Together, the two mechanisms lower blood pressure more than either medicine used on its own.
How it Works
Irbesartan selectively blocks the AT1 receptor, preventing angiotensin II from constricting blood vessels and retaining sodium, while hydrochlorothiazide inhibits sodium reabsorption at the distal tubule of the kidney, increasing urine output and reducing circulating fluid volume. The combined vasodilation and reduced fluid volume produce a greater blood-pressure-lowering effect than either drug alone.
Directions for Use
Take CoAprovel 150/12.5mg Tablet at about the same time each day, with or without food, and swallow the tablet whole with a glass of water. Do not stop taking this medicine suddenly without consulting your doctor, as blood pressure control needs to be continuous even once you feel well.
Dosage
The usual dose of CoAprovel 150/12.5mg Tablet is one tablet once daily. Your doctor will determine whether this combination dose is appropriate for you based on your response to irbesartan or hydrochlorothiazide monotherapy, and may adjust the dose depending on your blood pressure control and kidney function. Always take exactly as prescribed.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Dizziness or lightheadedness, especially when standing up
- Fatigue or tiredness
- Nausea
- Headache
- High potassium levels (may show as muscle weakness or irregular heartbeat)
- Back pain
Contraindications
- Known hypersensitivity to irbesartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any ingredient in this product
- Anuria (inability to produce urine) or severe kidney impairment
- Pregnancy (can cause harm to the developing baby, especially in the second and third trimester)
- Severe liver impairment
- Concomitant use with aliskiren in patients with diabetes or kidney impairment
Drug / Food Interactions
- Potassium supplements or potassium-sparing diuretics may raise the risk of high blood potassium
- NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function
- Lithium levels may increase when combined with this medicine
- Alcohol, barbiturates, or narcotics may worsen dizziness from low blood pressure on standing
Quick Tips
- Take at the same time each day to build a consistent routine
- Monitor your blood pressure regularly as advised by your doctor
- Rise slowly from sitting or lying down to reduce dizziness
- Attend scheduled blood tests to check kidney function and electrolyte levels
Frequently Asked Questions
What is CoAprovel 150/12.5mg Tablet used for?
CoAprovel 150/12.5mg Tablet is used to treat high blood pressure that is not fully controlled by either irbesartan or hydrochlorothiazide alone. Your doctor will confirm the specific reason it has been prescribed for you.
Why does this tablet contain two different medicines?
Combining an ARB with a thiazide diuretic lowers blood pressure through two different mechanisms at once, giving a stronger effect than either medicine alone at a similar dose.
Can I stop taking this medicine once my blood pressure is normal?
No, do not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause it to rise again.
Will this medicine make me urinate more often?
Yes, the hydrochlorothiazide component increases urination, especially in the first few weeks. This effect usually becomes less noticeable over time.
What should I do if I miss a dose of CoAprovel 150/12.5mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy CoAprovel 150/12.5mg Tablet from DoctorOnCall?
Yes, CoAprovel 150/12.5mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use CoAprovel 150/12.5mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for CoAprovel 150/12.5mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for CoAprovel 150/12.5mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for CoAprovel 150/12.5mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for CoAprovel 150/12.5mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Irbesartan 150mg
- Hydrochlorothiazide 12.5mg
Safety Advice
Pregnancy
This medicine is not considered safe during pregnancy and should be avoided.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
