CoAprovel 300/25mg Tablet

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Manufacturer Sanofi
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

CoAprovel 300/25mg Tablet is a prescription-only medicine (POM) that contains Irbesartan 300mg and Hydrochlorothiazide 25mg. It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, CoAprovel 300/25mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take CoAprovel 300/25mg Tablet at about the same time each day, with or without food. Swallow the tablet whole with a glass of water. Do not stop taking this medicine suddenly without consulting your doctor, even if you feel well, as blood pressure control needs to be continuous.

Dosage

CoAprovel 300/25mg Tablet is usually taken once daily. Your doctor will determine whether this specific strength combination is appropriate for you based on your blood pressure response to lower-dose combinations or individual components.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or lightheadedness, especially when standing up
  • Fatigue or tiredness
  • Nausea
  • Headache
  • High potassium levels (may show as muscle weakness or irregular heartbeat)
  • Back pain

Contraindications

  • Known hypersensitivity to irbesartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any ingredient in this product
  • Pregnancy (can cause harm to the developing baby, especially in the second and third trimester)
  • Anuria (inability to produce urine) or severe kidney impairment
  • Severe liver impairment
  • Concomitant use with aliskiren in patients with diabetes or kidney impairment

Drug / Food Interactions

  • Potassium supplements or potassium-sparing diuretics may increase the risk of high blood potassium
  • Lithium levels may increase when combined with this product
  • NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function
  • Alcohol, barbiturates, or narcotics may increase the risk of low blood pressure on standing

Quick Tips

  • Take at the same time each day to build a consistent routine
  • Monitor your blood pressure and periodic blood tests (electrolytes, kidney function) as advised by your doctor
  • Rise slowly from sitting or lying down to reduce dizziness
  • Limit prolonged sun exposure and use sun protection, as thiazide diuretics can increase photosensitivity

Ingredients / Active Ingredients

  • Irbesartan 300mg
  • Hydrochlorothiazide 25mg

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandSanofi-Aventis
ManufacturerSanofi
ClassificationPrescription medicine
Ingredients / Active IngredientsIrbesartan
Pack Size14s, 28s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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