CoAprovel 300/25mg Tablet
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Overview
CoAprovel 300/25mg Tablet is a fixed-dose combination containing irbesartan 300mg (an angiotensin II receptor blocker, or ARB) and hydrochlorothiazide 25mg (a thiazide diuretic). It is used to treat high blood pressure (hypertension) in patients whose blood pressure is not adequately controlled with irbesartan or a thiazide diuretic alone.
Irbesartan blocks the action of angiotensin II, a hormone that narrows blood vessels and promotes salt and water retention, while hydrochlorothiazide increases the excretion of salt and water by the kidneys. Together, these complementary mechanisms provide a greater blood-pressure-lowering effect than either medicine alone.
How it Works
Irbesartan selectively blocks the AT1 receptor, preventing angiotensin II from narrowing blood vessels and triggering aldosterone release. Hydrochlorothiazide acts on the distal renal tubule to reduce sodium and chloride reabsorption, increasing urine output and reducing circulating fluid volume. Combining these two actions produces a more pronounced and sustained reduction in blood pressure.
Directions for Use
Take CoAprovel 300/25mg Tablet at about the same time each day, with or without food. Swallow the tablet whole with a glass of water. Do not stop taking this medicine suddenly without consulting your doctor, even if you feel well, as blood pressure control needs to be continuous.
Dosage
CoAprovel 300/25mg Tablet is usually taken once daily. Your doctor will determine whether this specific strength combination is appropriate for you based on your blood pressure response to lower-dose combinations or individual components.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Dizziness or lightheadedness, especially when standing up
- Fatigue or tiredness
- Nausea
- Headache
- High potassium levels (may show as muscle weakness or irregular heartbeat)
- Back pain
Contraindications
- Known hypersensitivity to irbesartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any ingredient in this product
- Pregnancy (can cause harm to the developing baby, especially in the second and third trimester)
- Anuria (inability to produce urine) or severe kidney impairment
- Severe liver impairment
- Concomitant use with aliskiren in patients with diabetes or kidney impairment
Drug / Food Interactions
- Potassium supplements or potassium-sparing diuretics may increase the risk of high blood potassium
- Lithium levels may increase when combined with this product
- NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function
- Alcohol, barbiturates, or narcotics may increase the risk of low blood pressure on standing
Quick Tips
- Take at the same time each day to build a consistent routine
- Monitor your blood pressure and periodic blood tests (electrolytes, kidney function) as advised by your doctor
- Rise slowly from sitting or lying down to reduce dizziness
- Limit prolonged sun exposure and use sun protection, as thiazide diuretics can increase photosensitivity
Frequently Asked Questions
What is CoAprovel 300/25mg Tablet used for?
CoAprovel 300/25mg Tablet is used to treat high blood pressure that is not fully controlled by irbesartan or a thiazide diuretic alone, combining an ARB with a diuretic in one tablet.
Will this medicine make me urinate more often?
Yes, the hydrochlorothiazide component increases urine output, especially in the first few weeks. This is expected and usually settles with continued use.
Can I switch to CoAprovel 300/25mg Tablet from my current separate blood pressure tablets?
Your doctor can guide you on switching to this combination tablet if you are already stable on the individual components at matching doses, to simplify your regimen.
Can I stop taking this medicine if my blood pressure normalises?
No, do not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause your blood pressure to rise again.
What should I do if I miss a dose of CoAprovel 300/25mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy CoAprovel 300/25mg Tablet from DoctorOnCall?
Yes, CoAprovel 300/25mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use CoAprovel 300/25mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for CoAprovel 300/25mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for CoAprovel 300/25mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for CoAprovel 300/25mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for CoAprovel 300/25mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Irbesartan 300mg
- Hydrochlorothiazide 25mg
Safety Advice
Pregnancy
This medicine is not considered safe during pregnancy and should be avoided.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
