Pharmaniaga Glumet XR 750mg Tablet

Pharmaniaga Glumet XR 750mg Tablet is an extended-release (XR) formulation of metformin hydrochloride, a first-line biguanide medicine used to help manage type 2 diabetes mellitus in adults. Each tablet contains 750mg of metformin in a modified-release matrix that releases the active ingredient gradually over several hours, which is why it is usually taken only once daily, typically with the evening meal. Glumet XR 750mg Tablet is a prescription-only medicine in Malaysia and must be prescribed and monitored by a doctor as part of an overall diabetes care plan that also includes diet and physical activity.

By lowering blood glucose without stimulating insulin release from the pancreas, Glumet XR carries a low risk of hypoglycaemia when used alone and is often the first medicine doctors consider for type 2 diabetes. It is manufactured by Pharmaniaga and is not intended for type 1 diabetes or diabetic ketoacidosis. Through DoctorOnCall, patients with an existing valid prescription, or those who complete an online medical consultation, can have Glumet XR 750mg Tablet reviewed, dispensed, and delivered by a registered pharmacist in Malaysia and Singapore.

Metformin lowers blood glucose mainly by reducing glucose production in the liver, decreasing intestinal absorption of glucose, and improving the body’s sensitivity to insulin so that muscle and fat tissue can take up and use glucose more effectively. Because it does not force the pancreas to release more insulin, it does not typically cause low blood sugar on its own. In the XR formulation, a special release matrix slows down how quickly the tablet dissolves, spreading drug absorption over many hours to give steadier metformin blood levels across the day and generally better stomach tolerability compared with immediate-release metformin.

Take Glumet XR 750mg Tablet exactly as prescribed by your doctor, usually once daily with the evening meal. Swallow the tablet whole with a glass of water; do not crush, split, or chew it, as breaking the tablet can disrupt the extended-release matrix and increase the risk of side effects. If you are switching from another metformin product, your doctor will advise the correct starting dose and timing for the change. Do not stop or adjust your dose on your own, even if your blood glucose readings appear normal, as this can affect long-term diabetes control.

The dose of Glumet XR 750mg Tablet is individualised by your prescribing doctor based on your blood glucose control, kidney function, and response to treatment, and should never be self-adjusted. Treatment is often started at a lower dose and increased gradually over several weeks to reduce gastrointestinal side effects, with your doctor confirming the appropriate maintenance dose at follow-up visits. Regular monitoring of blood glucose, HbA1c, and kidney function is required while you are taking this medicine. If a dose is missed, take it as soon as you remember unless it is close to the time of your next dose; do not take a double dose to make up for the one missed.

Please refer to the expiry date printed on the blister strip or carton, and do not use Glumet XR 750mg Tablet beyond this date.

Store Glumet XR 750mg Tablet below 30°C in a dry place, away from direct sunlight and moisture, and keep it out of the reach of children. Keep tablets in their original blister packaging until you are ready to take them.

• Known hypersensitivity to metformin or any ingredient in the tablet.
• Severe kidney impairment.
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• Severe liver impairment.
• Conditions associated with tissue hypoxia, such as recent heart attack, severe heart failure, or shock.
• Acute conditions with risk of altered kidney function, such as severe dehydration or serious infection.

• Iodinated contrast media used in imaging studies may increase the risk of lactic acidosis; metformin may need to be paused before and after such procedures.
• Alcohol can increase the risk of lactic acidosis and low blood sugar when taken with metformin.
• Certain diuretics, corticosteroids, and some blood pressure medicines may affect blood glucose control.
• Other diabetes medicines, including insulin and sulfonylureas, may increase the risk of hypoglycaemia when combined with metformin.
• Cimetidine may increase metformin blood levels.

• Take Glumet XR with your evening meal to reduce stomach upset.
• Swallow the tablet whole — never crush, split, or chew it.
• Attend all scheduled blood tests to monitor kidney function and vitamin B12 levels.
• Continue your prescribed diet and exercise plan alongside this medicine.
• Inform your doctor before any surgery or contrast imaging scan.
• Carry a note stating you are on metformin therapy, especially when travelling.

Precautions: Glumet XR 750mg Tablet should be used with caution in elderly patients, people with reduced kidney function, and those who consume alcohol regularly, as these factors increase the risk of lactic acidosis. It is not recommended during pregnancy or breastfeeding unless specifically advised by a doctor, and is not intended for children.

When to See a Doctor or Pharmacist: Seek prompt medical advice if you experience persistent vomiting, severe abdominal pain, difficulty breathing, unusual muscle pain, or unusually low body temperature, as these may indicate lactic acidosis. Contact DoctorOnCall’s pharmacist team if you have questions about your dose, a missed dose, or possible side effects.