Pharmaniaga Mefenemic Acid 250mg Capsule

Pharmaniaga Mefenemic Acid 250mg Capsule contains mefenamic acid 250mg, a fenamate-class non-steroidal anti-inflammatory drug (NSAID) in capsule form, prescribed for the short-term relief of mild to moderate pain such as menstrual cramps, headache, and generalised muscle or joint discomfort. The 250mg capsule strength is often used when a lower per-dose amount is appropriate, such as for patients who are more sensitive to NSAIDs, or as part of a dosing schedule that reaches the target daily amount across multiple smaller doses rather than fewer larger ones.

Mefenamic acid relieves pain by lowering the body’s production of prostaglandins, the chemical messengers responsible for pain, inflammation, fever, and uterine cramping. As with all NSAIDs used at an effective analgesic dose, this capsule carries recognised gastrointestinal and other risks, and is classified as a prescription medicine in Malaysia; a doctor’s assessment (available through DoctorOnCall’s online consultation service) is required before it is dispensed.

Mefenamic acid blocks the cyclooxygenase (COX-1 and COX-2) enzymes that generate prostaglandins from arachidonic acid, reducing the signals that make nerve endings more sensitive to pain and that trigger uterine muscle contractions during menstruation. By lowering the level of these inflammatory mediators, mefenamic acid reduces pain intensity and the cramping sensation associated with common short-term pain conditions.

Take Pharmaniaga Mefenemic Acid 250mg Capsule exactly as prescribed by your doctor, swallowing the capsule whole with a full glass of water, preferably with or after food to reduce the risk of stomach irritation. Do not open or break the capsule unless specifically instructed to do so by your doctor or pharmacist.

The typical prescribed dose for adults is one or two 250mg capsules taken up to three or four times a day as needed for pain, usually for a short course of no more than a few days to a week unless your doctor advises otherwise. Always follow your doctor’s specific dosing instructions and do not exceed the maximum daily dose stated on the label.

Use this medicine before the expiry date printed on the blister strip or carton. Do not use capsules beyond their expiry date, and dispose of any unused or expired capsules responsibly rather than storing them for future use.

Store below 30°C in a cool, dry place away from direct sunlight and moisture, keeping capsules in their original blister packaging until ready to use. Keep out of the reach and sight of children at all times.

• Known hypersensitivity to mefenamic acid, aspirin, or other NSAIDs, including a history of asthma, hives, or allergic reactions triggered by these medicines
• Active or recurrent peptic ulcer disease or gastrointestinal inflammation/bleeding
• Severe kidney or liver impairment
• Severe heart failure
• Third trimester of pregnancy

• Other NSAIDs or aspirin taken together increase the risk of stomach irritation and bleeding
• Blood thinners such as warfarin combined with mefenamic acid raise the risk of bleeding
• ACE inhibitors, ARBs, or diuretics used for blood pressure may be less effective and pose greater kidney risk when combined with mefenamic acid
• Corticosteroids taken alongside mefenamic acid further increase gastrointestinal ulcer risk
• Lithium and methotrexate levels may rise to unsafe levels when combined with mefenamic acid
• Alcohol increases the risk of stomach irritation and bleeding when combined with this medicine

• Take with food to reduce the chance of stomach upset
• Follow the exact number of capsules and frequency your doctor has prescribed rather than adjusting the dose yourself
• Avoid combining with other NSAIDs, aspirin, or excessive alcohol
• Watch for diarrhoea, which is relatively common with this medicine, and stay well hydrated
• Report black or bloody stools, persistent stomach pain, or unusual bruising to your doctor immediately
• Inform your doctor of any stomach, kidney, liver, or heart conditions before starting treatment

Pharmaniaga Mefenemic Acid 250mg Capsule is generally intended for short-term, as-needed pain relief rather than continuous long-term use, and repeated or prolonged courses should only continue under medical supervision given the cumulative NSAID-related risks. Anyone with a history of stomach ulcers, kidney disease, heart disease, or who is elderly should be assessed carefully before starting, and this capsule strength should not be combined with the 500mg tablet variant of mefenamic acid without your doctor’s specific instruction, to avoid unintentionally exceeding the maximum daily dose.