Ranbaxy Zeteze SM 10/40mg Tablet

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Brand Ranbaxy
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Ranbaxy Zeteze SM 10/40mg Tablet contains Ezetimibe 10mg and Simvastatin 40mg and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Ranbaxy Zeteze SM 10/40mg Tablet are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Take Ranbaxy Zeteze SM 10/40mg Tablet once daily in the evening, as simvastatin tends to work best when cholesterol production is naturally highest overnight. Swallow the tablet whole with a glass of water. Avoid grapefruit juice and grapefruit products throughout treatment, as this interaction is more pronounced with simvastatin than with most other statins and can significantly increase the risk of muscle-related side effects.

Dosage

The usual dose of Ranbaxy Zeteze SM 10/40mg Tablet is one tablet once daily in the evening, as prescribed by your doctor based on your cholesterol levels and cardiovascular risk. Your doctor will monitor your response with periodic blood tests and adjust treatment if needed.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Headache
  • Diarrhea
  • Joint pain
  • Fatigue
  • Stomach pain
  • Cough or respiratory issues
  • Dizziness
  • Elevated liver enzymes (when combined with statins)

Contraindications

  • Known hypersensitivity to ezetimibe, simvastatin, or any ingredient in this product
  • Active liver disease or unexplained persistent elevation of liver enzymes
  • Pregnancy and breastfeeding
  • Concomitant use with strong CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, HIV protease inhibitors, clarithromycin)
  • Concomitant use with gemfibrozil, cyclosporine, or danazol

Drug / Food Interactions

  • Grapefruit juice significantly raises simvastatin levels and should be avoided completely, more so than with most other statins
  • Strong CYP3A4 inhibitors raise simvastatin levels and increase the risk of muscle toxicity – some combinations are contraindicated
  • Amiodarone, verapamil, or diltiazem taken together increase the risk of muscle-related side effects and may require a lower simvastatin dose
  • Warfarin’s blood-thinning effect may be enhanced, requiring closer INR monitoring

Quick Tips

  • Take once daily in the evening, consistently
  • Completely avoid grapefruit juice and grapefruit products – this interaction is stronger with simvastatin than most other statins
  • Report unexplained muscle pain, tenderness, or weakness to your doctor promptly
  • Attend scheduled blood tests to monitor cholesterol and liver function
  • Limit alcohol intake, as it can increase the risk of liver-related side effects

Ingredients / Active Ingredients

  • Ezetimibe 10mg
  • Simvastatin 40mg

Safety Advice

Pregnancy

Limited Data

Limited information is available regarding use during pregnancy. Use only if clearly needed.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Generally Safe

Generally safe, but caution may be required in some patients.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandRanbaxy
ClassificationPrescription medicine
Ingredients / Active IngredientsEzetimibe
Pack Size28s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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