Triplixam 5/1.25/10mg Tablet
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Overview
Triplixam 5/1.25/10mgmg Tablet is a triple fixed-dose combination of perindopril (an ACE inhibitor), indapamide (a thiazide-like diuretic), and amlodipine (a calcium channel blocker), used to treat high blood pressure in adults whose hypertension is already controlled by these three medicines taken together.
Each medicine lowers blood pressure through a different pathway: perindopril relaxes blood vessels by blocking a hormone that narrows them, indapamide helps the kidneys remove excess salt and water, and amlodipine relaxes blood vessel walls directly – together giving more complete blood pressure control.
How it Works
Perindopril blocks the angiotensin-converting enzyme, reducing production of a hormone that narrows blood vessels. Indapamide acts on the kidneys to increase excretion of sodium and water, reducing blood volume. Amlodipine blocks calcium entry into blood vessel wall muscle cells, causing them to relax. Together, these three actions produce a stronger blood pressure-lowering effect than any one medicine alone.
Directions for Use
Take the tablet once daily in the morning, before breakfast, swallowed whole with a glass of water.
Dosage
The usual dose is one 5/1.25/10mgmg tablet taken once daily, preferably in the morning before a meal. Your doctor determines the appropriate strength based on your prior response to the individual medicines.
Shelf Life
Refer to the expiry date printed on the packaging.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Dizziness or lightheadedness, especially when standing up quickly
- Headache
- Muscle cramps or weakness
- Increased urination
- Nausea or upset stomach
- Fatigue or tiredness
- Low potassium levels (may require monitoring)
Contraindications
- Known hypersensitivity to perindopril or any ACE inhibitor, indapamide or other sulfonamides, amlodipine or other dihydropyridines, or any excipient
- History of angioedema related to previous ACE inhibitor treatment
- Pregnancy and breastfeeding
- Severe kidney impairment or severe liver impairment/hepatic encephalopathy
- Concurrent use with aliskiren-containing medicines in patients with diabetes or kidney impairment
Drug / Food Interactions
- Potassium-sparing diuretics, potassium supplements, or salt substitutes may increase blood potassium to dangerous levels when combined with perindopril.
- NSAIDs (such as ibuprofen) may reduce the blood pressure-lowering effect and increase the risk of kidney problems.
- Lithium levels may rise when taken with this medicine, requiring closer monitoring.
- Inform your doctor of all medicines you are taking, including other blood pressure or heart medicines.
Quick Tips
- Attend all scheduled blood tests to monitor your kidney function and blood potassium/sodium levels.
- Rise slowly from sitting or lying positions to reduce dizziness, especially when starting treatment.
- Report a persistent dry cough to your doctor, as this is a known effect of the perindopril component.
- Do not stop this medicine suddenly without consulting your doctor.
Frequently Asked Questions
What is Triplixam used for?
Triplixam is a triple combination of perindopril, indapamide, and amlodipine used to treat high blood pressure that requires all three medicines together.
How does Triplixam lower blood pressure?
It combines three mechanisms: perindopril relaxes blood vessels, indapamide removes excess salt and water via the kidneys, and amlodipine relaxes blood vessel walls directly.
Can I switch to Triplixam directly if I have not tried the individual medicines?
This combination is intended for patients already stabilised on all three medicines separately – your doctor will confirm if it is appropriate for you.
Why do I need regular blood tests on this medicine?
Blood tests monitor your kidney function and blood potassium and sodium levels, which can be affected by this combination.
What should I do if I develop a persistent dry cough?
Report it to your doctor – a dry cough is a recognised effect of the perindopril (ACE inhibitor) component and may require a treatment review.
Can I take this medicine if I am pregnant?
No, this medicine is not safe during pregnancy and can seriously harm the developing baby – inform your doctor immediately if you become pregnant.
Can I take potassium supplements or salt substitutes with this medicine?
Avoid these unless specifically directed by your doctor, as they can raise blood potassium to dangerous levels when combined with perindopril.
Can I buy Triplixam 5/1.25/10mg Tablet from DoctorOnCall?
Yes, Triplixam 5/1.25/10mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Triplixam 5/1.25/10mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Triplixam 5/1.25/10mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Triplixam 5/1.25/10mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Triplixam 5/1.25/10mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Triplixam 5/1.25/10mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Perindopril arginine 5mg
- Indapamide 1.25mg
- Amlodipine 10mgmg (as amlodipine besylate)
Safety Advice
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
