Vytorin 10/40 mg Tablet

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Brand MSD
Manufacturer MSD
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last reviewed on

Overview

Vytorin 10/40 mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Ezetimibe 10mg and Simvastatin 40mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Vytorin 10/40 mg Tablet once daily in the evening, with or without food, and swallow the tablet whole with a glass of water. Taking it consistently at the same time each evening helps maintain steady cholesterol control, since cholesterol production is normally highest overnight.

Dosage

Vytorin 10/40 mg Tablet is usually taken as one tablet once daily in the evening, as instructed by your doctor. The specific strength prescribed is based on your cholesterol levels, cardiovascular risk, and response to previous cholesterol-lowering treatment, and should not be changed without medical advice.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Headache
  • Diarrhea
  • Joint pain
  • Fatigue
  • Stomach pain
  • Cough or respiratory issues
  • Dizziness
  • Elevated liver enzymes (when combined with statins)

Contraindications

  • Known hypersensitivity to ezetimibe, simvastatin, or any ingredient in this product
  • Active liver disease or unexplained persistent elevation of liver enzymes
  • Pregnancy and breastfeeding
  • Concomitant use with strong CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, certain HIV protease inhibitors, clarithromycin)
  • Concomitant use with gemfibrozil or ciclosporin

Drug / Food Interactions

  • Strong CYP3A4 inhibitors (e.g. itraconazole, clarithromycin, HIV protease inhibitors) significantly increase simvastatin levels and the risk of muscle toxicity
  • Grapefruit juice can raise simvastatin blood levels and should be avoided or limited
  • Gemfibrozil and other fibrates increase the risk of muscle-related side effects when combined
  • Warfarin’s blood-thinning effect may be enhanced, requiring closer INR monitoring

Quick Tips

  • Take in the evening at the same time each day for consistent effect
  • Report unexplained muscle pain, tenderness, or weakness to your doctor promptly
  • Avoid or strictly limit grapefruit juice while taking this medicine
  • Attend scheduled blood tests to monitor cholesterol and liver function
  • Continue taking this medicine even if your cholesterol improves, unless your doctor advises otherwise

Ingredients / Active Ingredients

  • Ezetimibe 10mg
  • Simvastatin 40mg

Safety Advice

Pregnancy

Limited Data

Limited information is available regarding use during pregnancy. Use only if clearly needed.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Generally Safe

Generally safe, but caution may be required in some patients.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandMSD
ManufacturerMSD
ClassificationPrescription medicine
Ingredients / Active IngredientsEzetimibe
Pack Size10s, 30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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