Zovirax 5% Cream

Brand GSK
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  • FDA Approved
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Zovirax 5% Cream is supplied as a cream, with Aciclovir 5% w/w. It is supplied in a pack size of 10g.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Wash your hands before and after applying. Apply a thin layer of Zovirax 5% Cream to the affected area as soon as the first symptoms appear, and reapply approximately every 4 hours, around 5 times a day, for 5 to 10 days, continuing until the lesion has healed. Use a clean fingertip or cotton bud to avoid spreading the virus to other parts of the body or to other people, and do not share your tube of Zovirax with anyone else.

Dosage

For adults and adolescents, apply Zovirax 5% Cream 5 times a day at roughly 4-hour intervals for 5 to 10 days, starting treatment as early as possible — ideally at the very first tingling or itching sensation, since treatment started after the blister has fully formed is less effective. If the cold sore has not healed after 10 days of consistent use, stop and consult a doctor or pharmacist.

Storage Instructions

Store below 30°C in a cool, dry place away from direct sunlight. Keep the tube tightly closed after each use. Do not freeze. Keep out of the reach and sight of children.

Side Effects

  • Nausea or vomiting
  • Headache
  • Dizziness
  • Diarrhoea
  • Joint or muscle pain
  • Fatigue or tiredness
  • Mild rash or skin reaction

Contraindications

  • Known hypersensitivity or allergy to aciclovir, valaciclovir, propylene glycol, or any other ingredient in Zovirax Cream
  • Not for use inside the mouth, in the eyes, or on genital herpes sores without a doctor’s advice, as alternative formulations or oral treatment may be more appropriate
  • Not intended for use on broken or actively weeping skin outside the typical cold sore area without medical advice
  • Pregnant or breastfeeding women should consult a doctor or pharmacist before use
  • Consult a doctor if cold sores are unusually frequent, severe, or occur in someone with a weakened immune system

Drug / Food Interactions

  • Topical aciclovir in Zovirax Cream has very low systemic absorption, so significant drug interactions are unlikely with normal use
  • Avoid applying other lip balms, cosmetics, or creams directly onto an active cold sore at the same time as Zovirax, as this may reduce its effectiveness
  • No significant food interactions are expected with topical use
  • Let your pharmacist know if you are taking oral antiviral medicines for herpes, in case of any specific guidance

Quick Tips

  • Apply Zovirax at the very first tingling, itching, or burning sensation for the best results
  • Use a clean fingertip or cotton bud rather than repeatedly touching the sore with bare fingers
  • Avoid picking, squeezing, or scratching the cold sore, and avoid kissing or sharing drinks/utensils while it is active
  • Wash your hands thoroughly after each application
  • Use lip sunscreen or balm with SPF if sunlight tends to trigger your cold sores
  • See a doctor if the sore does not improve within 10 days, recurs frequently, or spreads beyond the usual area

Ingredients / Active Ingredients

  • Aciclovir 5% w/w (active ingredient)
  • Cream base formulated for topical application to skin around the lips
  • Emulsifying and thickening agents that give the cream its texture
  • Preservative system to maintain product stability
  • Purified water as the vehicle base

Safety Advice

Pregnancy

Safe If Prescribed

This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Generally Safe

Consuming alcohol with this medicine is generally safe, but moderate intake is advised.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Cold sores are caused by the herpes simplex virus, which remains dormant in nerve tissue after the initial infection and can reactivate due to triggers such as stress, illness, fatigue, hormonal changes, or sun exposure. Zovirax 5% Cream treats an active outbreak but does not cure or remove the underlying virus, so cold sores can recur over time. Anyone who experiences very frequent or unusually severe outbreaks, or who has a weakened immune system, should discuss further management with a doctor.

Frequently Asked Questions

Product Specifications

BrandGSK
ClassificationNon-prescription
Ingredients / Active IngredientsAcyclovir
Weight10g
Shelf LifeZovirax 5% Cream is valid for use up to the expiry date printed on the tube and outer packaging when stored correctly and unopened. Always check the expiry date before use and do not use the cream if it has expired.

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Important Medical Information

💊 Recommended Dosage:

For adults and adolescents, apply Zovirax 5% Cream 5 times a day at roughly 4-hour intervals for 5 to 10 days, starting treatment as early as possible — ideally at the very first tingling or itching sensation, since treatment started after the blister has fully formed is less effective. If the cold sore has not healed after 10 days of consistent use, stop and consult a doctor or pharmacist.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity or allergy to aciclovir, valaciclovir, propylene glycol, or any other ingredient in Zovirax Cream
  • Not for use inside the mouth, in the eyes, or on genital herpes sores without a doctor’s advice, as alternative formulations or oral treatment may be more appropriate
  • Not intended for use on broken or actively weeping skin outside the typical cold sore area without medical advice
  • Pregnant or breastfeeding women should consult a doctor or pharmacist before use
  • Consult a doctor if cold sores are unusually frequent, severe, or occur in someone with a weakened immune system
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Headache
  • Dizziness
  • Diarrhoea
  • Joint or muscle pain
  • Fatigue or tiredness
  • Mild rash or skin reaction
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.