Glucophage XR 750mg Tablet

Glucophage XR 750mg Tablet is an extended-release formulation of Metformin HCl, a biguanide-class oral antidiabetic medicine used in the management of type 2 diabetes mellitus. The extended-release design allows the tablet to release its active ingredient gradually over several hours, providing steady blood glucose control with once-daily dosing for many patients, and is often preferred for its more consistent drug levels and generally better gastrointestinal tolerability compared to immediate-release metformin.

Glucophage XR 750mg Tablet is a prescription-only medicine in Malaysia. It must be prescribed by a registered doctor following an assessment of the patient’s blood glucose control, kidney function, and overall health, and can be obtained through DoctorOnCall after an online consultation confirms it is suitable. It is usually used alongside a structured diet and exercise programme as advised by the treating doctor.

Metformin works mainly by reducing the amount of glucose produced and released by the liver, and by improving the sensitivity of muscle and fat tissue to insulin, which increases glucose uptake and utilisation. It does not stimulate the pancreas to release more insulin, so it carries a low risk of causing hypoglycaemia when used alone. The extended-release matrix of Glucophage XR slowly releases metformin as it passes through the gastrointestinal tract, giving smoother, more sustained blood glucose control over the day.

Take Glucophage XR 750mg Tablet exactly as prescribed by your doctor, usually once daily with the evening meal unless advised otherwise. Swallow the tablet whole with a glass of water — do not crush, chew, or split it, as this can affect the extended-release mechanism and how the medicine is absorbed. Do not stop or change the dose without first consulting your doctor, even if you feel your blood glucose is well controlled.

Dosage of Glucophage XR 750mg Tablet is individualised by the prescribing doctor based on blood glucose readings, kidney function, and response to treatment, and may be adjusted gradually to the lowest effective dose. This medicine requires a valid doctor’s prescription and should never be started, stopped, or adjusted without medical advice, as inappropriate dosing can affect blood glucose control or increase the risk of side effects, particularly in patients with reduced kidney function.

Glucophage XR 750mg Tablet is generally stable for the shelf life stated on the carton when stored correctly and unopened. Always check the expiry date printed on the packaging before use, and do not use the tablets after this date. Your pharmacist can confirm the exact expiry date on the specific pack dispensed to you.

Store Glucophage XR 750mg Tablet below 30°C in a cool, dry place away from direct sunlight and moisture, in its original packaging until ready for use. Keep out of reach and sight of children. Do not store in the bathroom or near a sink, and do not use tablets that appear discoloured or damaged.

• Known hypersensitivity to metformin or any component of the tablet
• Severe kidney impairment or acute kidney injury
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis
• Severe liver impairment
• Conditions with risk of tissue hypoxia, such as recent heart attack, severe heart failure, or shock
• Planned use of iodinated contrast media for imaging — treatment may need temporary interruption
• Excessive alcohol intake

• Iodinated contrast agents used in radiological procedures may increase the risk of lactic acidosis and kidney impairment
• Certain diuretics, corticosteroids, and other medicines that affect kidney function or blood glucose may alter metformin’s effect
• Alcohol may increase the risk of lactic acidosis, especially with excessive intake
• Other antidiabetic medicines may increase the risk of hypoglycaemia when combined
• Inform your doctor or pharmacist of all prescription, over-the-counter, and herbal products you are taking

• Take with the evening meal to help reduce stomach upset
• Swallow the tablet whole — never crush, chew, or split it
• Attend regular follow-up appointments so your doctor can monitor blood glucose and kidney function
• Inform your doctor if you are scheduled for any contrast imaging (such as a CT scan) or surgery
• Watch for unusual muscle pain, breathing difficulty, or extreme tiredness and seek medical attention promptly if these occur
• Do not double the dose if you miss one — continue with the next scheduled dose

Glucophage XR 750mg Tablet is a prescription antidiabetic medicine and should only be used under ongoing medical supervision. Regular monitoring of blood glucose, HbA1c, and kidney function is important to ensure the medicine remains effective and safe. Patients should not share this medicine with others and should always consult their doctor or a DoctorOnCall pharmacist before making any changes to their diabetes treatment plan.