Glymet 5/500mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Overview

Glymet 5/500mg Tablet is supplied as a tablet, with Glibenclamide 5mg and Metformin 500mg. It is supplied in pack sizes of 14s and 56s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Take Glymet 5/500mg Tablet exactly as prescribed by your doctor, usually with meals to help reduce stomach upset and to align dosing with food intake, which is important given the hypoglycaemia risk associated with glibenclamide. Swallow the tablet with a glass of water. Do not skip meals after taking this medicine, and do not change your dose without consulting your doctor.

Dosage

The dose of Glymet 5/500mg Tablet is individualised by the prescribing doctor based on blood glucose control, kidney and liver function, and response to treatment, and is typically started at a low dose and adjusted gradually. This medicine requires a valid doctor’s prescription; never start, stop, or adjust the dose without medical advice, as incorrect dosing can lead to hypoglycaemia (from glibenclamide) or other complications.

Shelf Life

Glymet 5/500mg Tablet is generally stable for the shelf life stated on the packaging when stored correctly and unopened. Always check the expiry date printed on the carton or blister strip before use, and do not use the tablets after this date.

Storage Instructions

Store Glymet 5/500mg Tablet below 30°C in a cool, dry place away from direct sunlight and moisture, in its original packaging. Keep out of reach and sight of children. Do not store in the bathroom or near a sink where humidity is high.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to glibenclamide, metformin, or other sulfonylureas/biguanides
  • Type 1 diabetes or diabetic ketoacidosis
  • Severe kidney or liver impairment
  • Conditions with risk of tissue hypoxia, such as severe heart failure, shock, or recent heart attack
  • Porphyria
  • Planned use of iodinated contrast media for imaging without temporary treatment interruption

Drug / Food Interactions

  • Other antidiabetic medicines, insulin, or alcohol can increase the risk of hypoglycaemia when combined with Glymet
  • Certain medicines such as beta-blockers may mask the warning signs of hypoglycaemia
  • Iodinated contrast agents may increase the risk of lactic acidosis and kidney impairment
  • Corticosteroids and some diuretics may raise blood glucose and reduce the medicine’s effectiveness
  • Inform your doctor or pharmacist of all other medicines, supplements, and herbal products you are taking

Quick Tips

  • Take with meals and do not skip meals after dosing, to reduce the risk of hypoglycaemia
  • Carry a fast-acting sugar source in case of low blood glucose symptoms such as sweating, shakiness, or confusion
  • Attend regular follow-up appointments to monitor blood glucose, kidney, and liver function
  • Inform your doctor before any contrast imaging (such as a CT scan) or surgery
  • Limit alcohol intake while on this medicine
  • Do not double the dose if you miss one — take the next dose at the usual time

Ingredients / Active Ingredients

  • Glibenclamide 5mg (active ingredient)
  • Metformin 500mg (active ingredient)

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Glymet 5/500mg Tablet combines two antidiabetic agents in a single tablet and requires careful, ongoing medical supervision because of the added hypoglycaemia risk from glibenclamide alongside the metabolic considerations of metformin. Patients should not adjust their treatment without medical guidance and should always consult their doctor or a DoctorOnCall pharmacist with any concerns about their diabetes management.

Frequently Asked Questions

Product Specifications

BrandOrient Europharma
ClassificationNon-prescription
Ingredients / Active IngredientsMetformin
Pack Size14s, 56s

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Important Medical Information

💊 Recommended Dosage:

The dose of Glymet 5/500mg Tablet is individualised by the prescribing doctor based on blood glucose control, kidney and liver function, and response to treatment, and is typically started at a low dose and adjusted gradually. This medicine requires a valid doctor’s prescription; never start, stop, or adjust the dose without medical advice, as incorrect dosing can lead to hypoglycaemia (from glibenclamide) or other complications.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to glibenclamide, metformin, or other sulfonylureas/biguanides
  • Type 1 diabetes or diabetic ketoacidosis
  • Severe kidney or liver impairment
  • Conditions with risk of tissue hypoxia, such as severe heart failure, shock, or recent heart attack
  • Porphyria
  • Planned use of iodinated contrast media for imaging without temporary treatment interruption
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.