Janumet 50/500mg Tablet
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Overview
Janumet 50/500mg Tablet is a fixed-dose combination tablet containing sitagliptin 50mg and metformin 500mg, used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Sitagliptin and metformin lower blood sugar through complementary mechanisms: sitagliptin (a DPP-4 inhibitor) increases the body’s own insulin release after meals and reduces excess sugar production by the liver, while metformin reduces the liver’s glucose output and improves the body’s sensitivity to insulin.
How it Works
Sitagliptin inhibits the DPP-4 enzyme, prolonging the action of incretin hormones that stimulate insulin release from the pancreas in response to meals and suppress glucagon secretion. Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and improves peripheral insulin sensitivity. Together they provide complementary blood-sugar-lowering effects.
Directions for Use
Take Janumet 50/500mg Tablet with meals (usually morning and evening) to reduce the stomach-related side effects associated with metformin. Swallow the tablet whole with a glass of water; do not crush or chew it. Continue your prescribed diet and exercise plan alongside this medicine.
Dosage
Janumet 50/500mg Tablet is usually taken twice daily with meals, at a dose determined by your doctor based on your current diabetes treatment, blood sugar control, and kidney function. Do not adjust your dose without consulting your doctor, as both underdosing and overdosing can affect your blood sugar control.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea or vomiting
- Diarrhea
- Stomach discomfort or cramps
- Metallic taste in the mouth
- Loss of appetite
- Weight loss (in some cases)
Contraindications
- Known hypersensitivity to sitagliptin, metformin, or any ingredient in this product
- Severe kidney impairment
- Metabolic acidosis, including diabetic ketoacidosis
- Conditions predisposing to lactic acidosis (e.g. severe dehydration, severe infection, shock)
- Acute or chronic conditions causing tissue hypoxia (e.g. decompensated heart failure, respiratory failure)
Drug / Food Interactions
- Iodinated contrast media used in imaging studies require temporary discontinuation of metformin around the procedure due to kidney risk
- Alcohol increases the risk of lactic acidosis and should be limited
- Other diabetes medicines (e.g. sulfonylureas, insulin) increase the risk of low blood sugar when combined
- Diuretics, corticosteroids, and certain other medicines can affect blood sugar control and kidney function
Quick Tips
- Take with meals to reduce stomach upset
- Monitor your blood sugar as advised by your doctor and know the signs of low blood sugar
- Attend scheduled kidney function tests, as metformin dosing depends on kidney health
- Inform your doctor or radiographer that you take this medicine before any contrast dye imaging procedure
- Limit alcohol intake while on this medicine
Frequently Asked Questions
What is Janumet 50/500mg Tablet used for?
Janumet 50/500mg Tablet is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes.
Why does this medicine combine two different diabetes medicines?
Sitagliptin and metformin lower blood sugar through different, complementary mechanisms, so combining them in one tablet often provides better blood sugar control than either medicine alone, while simplifying your dosing routine.
Why should I take this medicine with food?
Taking it with meals significantly reduces the stomach-related side effects (such as nausea and diarrhoea) commonly associated with metformin.
Do I need to stop this medicine before a contrast dye scan?
Your doctor may advise temporarily stopping metformin-containing medicines before and after certain imaging procedures that use iodinated contrast dye, due to a rare risk to kidney function. Always inform your doctor and radiographer that you are taking this medicine.
What should I do if I miss a dose of Janumet 50/500mg Tablet?
Take the missed dose with your next meal as soon as you remember, unless it is almost time for your next scheduled dose – in that case, skip the missed dose and continue as normal. Do not double the dose.
Can I buy Janumet 50/500mg Tablet from DoctorOnCall?
Yes, Janumet 50/500mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Janumet 50/500mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Janumet 50/500mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Janumet 50/500mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Janumet 50/500mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Janumet 50/500mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Sitagliptin 50mg (as sitagliptin phosphate)
- Metformin hydrochloride 500mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
