Janumet 50/500mg Tablet

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Brand MSD
Manufacturer MSD
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Janumet 50/500mg Tablet is a prescription-only medicine (POM) that contains Sitagliptin 50mg (as sitagliptin phosphate) and Metformin hydrochloride 500mg. It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Janumet 50/500mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Janumet 50/500mg Tablet with meals (usually morning and evening) to reduce the stomach-related side effects associated with metformin. Swallow the tablet whole with a glass of water; do not crush or chew it. Continue your prescribed diet and exercise plan alongside this medicine.

Dosage

Janumet 50/500mg Tablet is usually taken twice daily with meals, at a dose determined by your doctor based on your current diabetes treatment, blood sugar control, and kidney function. Do not adjust your dose without consulting your doctor, as both underdosing and overdosing can affect your blood sugar control.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to sitagliptin, metformin, or any ingredient in this product
  • Severe kidney impairment
  • Metabolic acidosis, including diabetic ketoacidosis
  • Conditions predisposing to lactic acidosis (e.g. severe dehydration, severe infection, shock)
  • Acute or chronic conditions causing tissue hypoxia (e.g. decompensated heart failure, respiratory failure)

Drug / Food Interactions

  • Iodinated contrast media used in imaging studies require temporary discontinuation of metformin around the procedure due to kidney risk
  • Alcohol increases the risk of lactic acidosis and should be limited
  • Other diabetes medicines (e.g. sulfonylureas, insulin) increase the risk of low blood sugar when combined
  • Diuretics, corticosteroids, and certain other medicines can affect blood sugar control and kidney function

Quick Tips

  • Take with meals to reduce stomach upset
  • Monitor your blood sugar as advised by your doctor and know the signs of low blood sugar
  • Attend scheduled kidney function tests, as metformin dosing depends on kidney health
  • Inform your doctor or radiographer that you take this medicine before any contrast dye imaging procedure
  • Limit alcohol intake while on this medicine

Ingredients / Active Ingredients

  • Sitagliptin 50mg (as sitagliptin phosphate)
  • Metformin hydrochloride 500mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandMSD
ManufacturerMSD
ClassificationPrescription medicine
Ingredients / Active IngredientsMetformin
Pack Size56s, 7s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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Important Medical Information

💊 Recommended Dosage:

Janumet 50/500mg Tablet is usually taken twice daily with meals, at a dose determined by your doctor based on your current diabetes treatment, blood sugar control, and kidney function. Do not adjust your dose without consulting your doctor, as both underdosing and overdosing can affect your blood sugar control.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to sitagliptin, metformin, or any ingredient in this product
  • Severe kidney impairment
  • Metabolic acidosis, including diabetic ketoacidosis
  • Conditions predisposing to lactic acidosis (e.g. severe dehydration, severe infection, shock)
  • Acute or chronic conditions causing tissue hypoxia (e.g. decompensated heart failure, respiratory failure)
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.