Dyfenamic 250mg Capsule

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Dyfenamic 250mg Capsule contains Mefenamic Acid 250mg (single active ingredient per capsule) and is presented as a capsule. It is supplied in a pack size of 10s.

It is classified as a non-prescription medicine, so no prescription is needed to order it. Under Malaysian rules for medicine information, this page carries product, safety and handling information only.

You can consult a doctor or pharmacist online on DoctorOnCall about this product before or after you order. Every order is checked by a registered pharmacist before it is delivered. Always read the label and the leaflet supplied with the pack.

Directions for Use

Take Dyfenamic 250mg Capsule exactly as prescribed by your doctor, generally with or after food and a full glass of water to help protect the stomach lining; swallow the capsule whole without chewing or crushing it, and use the lowest effective dose for the shortest duration necessary to control your symptoms.

Dosage

The typical adult dose prescribed is an initial dose of 500mg (two capsules), followed by 250mg (one capsule) every six hours as needed for pain, usually for a maximum of seven days unless your doctor advises otherwise; a lower dose or different schedule may be prescribed for elderly patients or those with reduced kidney or liver function.

Shelf Life

Dyfenamic 250mg Capsule generally has a shelf life of up to 36 months from the date of manufacture when unopened and stored correctly; always check the expiry date printed on the packaging and do not use the product after this date.

Storage Instructions

Store Dyfenamic 250mg Capsule below 30°C in a dry place, away from direct sunlight and moisture, and keep it out of the reach and sight of children in its original packaging.

Side Effects

  • Stomach pain or discomfort
  • Nausea or vomiting
  • Diarrhea or constipation
  • Headache
  • Dizziness
  • Skin rash
  • Heartburn or indigestion

Contraindications

  • Active or history of peptic (stomach or duodenal) ulcer or gastrointestinal bleeding
  • Known hypersensitivity to mefenamic acid, aspirin, or other NSAIDs, including a history of asthma, bronchospasm, or angioedema triggered by these medicines
  • Severe kidney or liver impairment
  • Severe heart failure
  • Pregnancy, particularly during the third trimester
  • Active inflammatory bowel disease, such as Crohn’s disease or ulcerative colitis

Drug / Food Interactions

  • Anticoagulants such as warfarin, which may have an increased bleeding risk when combined with mefenamic acid
  • Other NSAIDs or aspirin, which increase the risk of gastrointestinal side effects
  • ACE inhibitors, ARBs, or diuretics, which may have reduced effectiveness and increase the risk of kidney problems
  • Lithium and methotrexate, as mefenamic acid can raise their blood levels
  • Corticosteroids and SSRIs, which increase the risk of gastrointestinal bleeding when taken together

Quick Tips

  • Only use Dyfenamic 250mg Capsule under the guidance of the prescribing doctor, and complete a DoctorOnCall online consultation before ordering
  • Take with food to reduce the risk of stomach upset
  • Avoid alcohol while taking this medicine, as it can increase the risk of stomach irritation
  • Do not use for longer than the prescribed duration without follow-up medical advice
  • Seek urgent medical attention if you notice black stools, vomiting blood, or severe stomach pain

Ingredients / Active Ingredients

  • Mefenamic Acid 250mg (single active ingredient per capsule)
  • Capsule shell, typically gelatin-based with manufacturer-specific colourants
  • Standard pharmaceutical excipients such as fillers, binders, and lubricants, which may vary by manufacturer and batch
  • No additional active pharmaceutical ingredients are combined in this formulation

Safety Advice

Pregnancy

Safe If Prescribed

This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Safe If Prescribed

Use only if prescribed, with possible monitoring of kidney function.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Because mefenamic acid carries a class-wide NSAID risk of gastrointestinal, cardiovascular, and renal side effects, your doctor may recommend periodic monitoring or follow-up, particularly if you use Dyfenamic 250mg Capsule regularly or have other risk factors such as older age, existing kidney disease, or concurrent use of other NSAIDs or blood-thinning medicines.

Frequently Asked Questions

Product Specifications

ClassificationNon-prescription
Ingredients / Active IngredientsMefenamic Acid
Pack Size10s

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Important Medical Information

💊 Recommended Dosage:

The typical adult dose prescribed is an initial dose of 500mg (two capsules), followed by 250mg (one capsule) every six hours as needed for pain, usually for a maximum of seven days unless your doctor advises otherwise; a lower dose or different schedule may be prescribed for elderly patients or those with reduced kidney or liver function.

🛑 Contraindications (Do not use if):
  • Active or history of peptic (stomach or duodenal) ulcer or gastrointestinal bleeding
  • Known hypersensitivity to mefenamic acid, aspirin, or other NSAIDs, including a history of asthma, bronchospasm, or angioedema triggered by these medicines
  • Severe kidney or liver impairment
  • Severe heart failure
  • Pregnancy, particularly during the third trimester
  • Active inflammatory bowel disease, such as Crohn’s disease or ulcerative colitis
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Stomach pain or discomfort
  • Nausea or vomiting
  • Diarrhea or constipation
  • Headache
  • Dizziness
  • Skin rash
  • Heartburn or indigestion
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.