Glucophage XR (Metformin) 1000mg Tablet

Brand Merck
Manufacturer Merck
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Glucophage XR 1000mg Tablet is supplied as a tablet, with Metformin Hydrochloride 1000mg. It is supplied in pack sizes of 60s-x3, 10s and 60s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Glucophage XR 1000mg Tablet is usually taken once daily with the evening meal, exactly as prescribed by the doctor. The tablet must be swallowed whole and never split, crushed, or chewed, as doing so can disrupt the extended-release mechanism and cause the full dose to be released too quickly. It is normal to occasionally notice something resembling the tablet shell in the stool, as the outer matrix is designed to pass through after releasing the active medicine.

Dosage

The dose of Glucophage XR 1000mg Tablet is individualised by the prescribing doctor, typically as part of a gradual increase from a lower XR strength based on blood glucose control and tolerability. Because it is an extended-release formulation, the total daily dose is generally taken as a single dose with the evening meal rather than split across the day, and any change should only be made by the doctor after reviewing blood glucose readings and kidney function.

Storage Instructions

Store below 30°C in a dry place, protected from direct light and humidity, and keep tablets in their original blister packaging until needed. Keep out of the sight and reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to metformin
  • Moderate to severe kidney impairment, as assessed by the prescribing doctor
  • Acute conditions with risk of altered kidney function, such as severe dehydration, serious infection, or shock
  • Unstable or acute decompensated heart failure
  • Conditions predisposing to tissue hypoxia, such as acute heart attack or severe respiratory failure
  • Planned use of iodinated contrast dye for imaging, unless timed by the doctor around the procedure
  • Any condition causing significant narrowing of the gastrointestinal tract, which may affect passage of the tablet matrix

Drug / Food Interactions

  • Iodinated contrast media used in certain imaging scans — Metformin may need to be temporarily stopped around the procedure on your doctor’s advice
  • Alcohol — excessive intake increases the risk of lactic acidosis, especially with liver problems or fasting
  • Certain diuretics, corticosteroids, and other medicines that can affect kidney function or blood glucose control
  • Other glucose-lowering medicines or insulin — combined use may increase the risk of low blood sugar and requires monitoring
  • Take with the evening meal as directed, as this supports the intended release profile and reduces gastrointestinal side effects

Quick Tips

  • Swallow Glucophage XR 1000mg Tablet whole; never crush, split, or chew it, as this disrupts the extended-release mechanism
  • Take it with your evening meal at a consistent time each day
  • Do not be alarmed if you notice a tablet-like residue in your stool; this is the empty matrix and does not mean the dose was not absorbed
  • Attend regular follow-ups so kidney function and blood glucose control can be monitored
  • Inform your doctor before any scan involving contrast dye or before surgery

Ingredients / Active Ingredients

  • Metformin Hydrochloride 1000mg (active ingredient, extended-release formulation)
  • Hypromellose and other polymers forming the extended-release matrix
  • Magnesium stearate as a lubricant
  • Film-coating agents as used in the branded formulation

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Glucophage XR 1000mg Tablet offers a once-daily dosing option at the highest standard Metformin strength, which many patients find more convenient than splitting an equivalent immediate-release dose across multiple meals. As with all Metformin-containing medicines, kidney function is assessed before treatment starts and monitored periodically thereafter, and DoctorOnCall’s online consultation process ensures these checks are in place before the prescription is confirmed or renewed.

Frequently Asked Questions

Product Specifications

BrandMerck
ManufacturerMerck
ClassificationNon-prescription
Ingredients / Active IngredientsMetformin
Pack Size10s, 60s, 60s x3
Shelf LifeGlucophage XR 1000mg Tablet is generally stable until the expiry date printed on the blister or carton when stored under the recommended conditions. Do not use tablets beyond the printed expiry date.

Customer Reviews

4.7 · 10 reviews
  • Verified purchase

    Nur Izzah · Purchased: 60s

    The seller shipped it very quickly and provided good service. I give a thumbs up to the boss and will buy from him next time!

  • Verified purchase

    S. Karthik · Purchased: 60s

    Harga murah dari kedai luar terbaik boleh repeat lagi nanti ok

  • Verified purchase

    Hana Maisarah · Purchased: 60s x3

    Very recommended to buy from this shop. The product received in good condition, well wrapped. Good services provided by seller, I am very satisfied.

  • Verified purchase

    Siti Raihana · Purchased: 60s x3

    First time use this brand & find it effective, affordable price & very fast shipping by seller, tq!

  • Verified purchase

    Elaine Teh · Purchased: 60s x3

    Barang dah sampai.. Di bungkus dgn elok.. Sampai pn cpt.. Tq seller.. Tq bnyk abg yg hantar kan td.. 5 bintang untk kedua2

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Important Medical Information

💊 Recommended Dosage:

The dose of Glucophage XR 1000mg Tablet is individualised by the prescribing doctor, typically as part of a gradual increase from a lower XR strength based on blood glucose control and tolerability. Because it is an extended-release formulation, the total daily dose is generally taken as a single dose with the evening meal rather than split across the day, and any change should only be made by the doctor after reviewing blood glucose readings and kidney function.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to metformin
  • Moderate to severe kidney impairment, as assessed by the prescribing doctor
  • Acute conditions with risk of altered kidney function, such as severe dehydration, serious infection, or shock
  • Unstable or acute decompensated heart failure
  • Conditions predisposing to tissue hypoxia, such as acute heart attack or severe respiratory failure
  • Planned use of iodinated contrast dye for imaging, unless timed by the doctor around the procedure
  • Any condition causing significant narrowing of the gastrointestinal tract, which may affect passage of the tablet matrix
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.