Glucophage XR 1000mg Tablet

Brand Merck
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Overview

Glucophage XR 1000mg Tablet is supplied as a tablet, with Metformin Hydrochloride 1000mg. It is supplied in pack sizes of 60s-x3, 10s and 60s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Glucophage XR 1000mg Tablet is usually taken once daily with the evening meal, exactly as prescribed by the doctor. The tablet must be swallowed whole and never split, crushed, or chewed, as doing so can disrupt the extended-release mechanism and cause the full dose to be released too quickly. It is normal to occasionally notice something resembling the tablet shell in the stool, as the outer matrix is designed to pass through after releasing the active medicine.

Dosage

The dose of Glucophage XR 1000mg Tablet is individualised by the prescribing doctor, typically as part of a gradual increase from a lower XR strength based on blood glucose control and tolerability. Because it is an extended-release formulation, the total daily dose is generally taken as a single dose with the evening meal rather than split across the day, and any change should only be made by the doctor after reviewing blood glucose readings and kidney function.

Shelf Life

Glucophage XR 1000mg Tablet is generally stable until the expiry date printed on the blister or carton when stored under the recommended conditions. Do not use tablets beyond the printed expiry date.

Storage Instructions

Store below 30°C in a dry place, protected from direct light and humidity, and keep tablets in their original blister packaging until needed. Keep out of the sight and reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to metformin
  • Moderate to severe kidney impairment, as assessed by the prescribing doctor
  • Acute conditions with risk of altered kidney function, such as severe dehydration, serious infection, or shock
  • Unstable or acute decompensated heart failure
  • Conditions predisposing to tissue hypoxia, such as acute heart attack or severe respiratory failure
  • Planned use of iodinated contrast dye for imaging, unless timed by the doctor around the procedure
  • Any condition causing significant narrowing of the gastrointestinal tract, which may affect passage of the tablet matrix

Drug / Food Interactions

  • Iodinated contrast media used in certain imaging scans — Metformin may need to be temporarily stopped around the procedure on your doctor’s advice
  • Alcohol — excessive intake increases the risk of lactic acidosis, especially with liver problems or fasting
  • Certain diuretics, corticosteroids, and other medicines that can affect kidney function or blood glucose control
  • Other glucose-lowering medicines or insulin — combined use may increase the risk of low blood sugar and requires monitoring
  • Take with the evening meal as directed, as this supports the intended release profile and reduces gastrointestinal side effects

Quick Tips

  • Swallow Glucophage XR 1000mg Tablet whole; never crush, split, or chew it, as this disrupts the extended-release mechanism
  • Take it with your evening meal at a consistent time each day
  • Do not be alarmed if you notice a tablet-like residue in your stool; this is the empty matrix and does not mean the dose was not absorbed
  • Attend regular follow-ups so kidney function and blood glucose control can be monitored
  • Inform your doctor before any scan involving contrast dye or before surgery

Frequently Asked Questions

Do I need a prescription to buy Glucophage XR 1000mg Tablet?

No. Glucophage XR 1000mg Tablet is a non-prescription product and can be ordered without a prescription. It is still dispensed by a registered pharmacist on DoctorOnCall.

What does Glucophage XR 1000mg Tablet contain?

Glucophage XR 1000mg Tablet is a tablet containing Metformin Hydrochloride 1000mg. The full ingredient list is shown in the Composition or Ingredients section on this page and on the product packaging.

What pack sizes does Glucophage XR 1000mg Tablet come in?

It is supplied in pack sizes of 60s-x3, 10s and 60s. Choose the pack size you need from the options shown on this page before adding the item to your cart.

Why is there no information here about what Glucophage XR 1000mg Tablet is for?

This page is limited to product, safety and handling information in line with Malaysian rules on medicine information. If you want advice on whether this product suits you, book an online consultation with a doctor or pharmacist on DoctorOnCall.

How should I use Glucophage XR 1000mg Tablet?

Use it exactly as stated on the pack label, without changing the amount or how often you use it. If anything on the label is unclear, check with a pharmacist before the first use, and read the Directions for Use section on this page.

Can I speak to a doctor or pharmacist about Glucophage XR 1000mg Tablet before I buy it?

Yes. DoctorOnCall offers online consultations with licensed doctors and registered pharmacists, so you can ask about this product, your existing medicines, or anything on the label before you place an order.

How should I store Glucophage XR 1000mg Tablet?

Store below 30°C in a dry place, protected from direct light and humidity, and keep tablets in their original blister packaging until needed. Keep out of the sight and reach of children. Keep it in its original pack and do not use it after the expiry date printed on the packaging.

What should I do if I notice side effects after using Glucophage XR 1000mg Tablet?

Stop using the product and speak to a doctor or pharmacist about any reaction that concerns you. Seek medical care immediately for signs of a severe reaction such as difficulty breathing, swelling of the face, lips or throat, or a widespread rash. Reported reactions are listed in the Side Effects section on this page.

How long will delivery take?

Within Malaysia, standard delivery takes 3 to 5 working days. Same-day delivery is available in the Klang Valley for orders placed before 12pm; orders placed after 12pm arrive by the end of the next day.

Orders to Singapore are sent as international deliveries and take 5 to 9 working days. A lump-sum shipping and handling fee applies to every overseas delivery and is shown at checkout.

What payment methods can I use?

Customers in Malaysia can pay by FPX online banking, credit or debit card (Visa and Mastercard), and supported e-wallets including Touch ‘n Go eWallet, GrabPay and ShopeePay.

FPX and local e-wallets are tied to Malaysian bank and wallet accounts, so if your delivery address is in Singapore, use the payment options displayed at checkout for that address rather than assuming the same list applies.

Can Glucophage XR 1000mg Tablet be delivered to Singapore?

Yes. DoctorOnCall ships to Singapore as an international order dispatched from Malaysia, arriving in 5 to 9 working days with a lump-sum shipping and handling fee.

Singapore’s Health Sciences Authority (HSA) allows personal imports of up to three months’ supply of a medicine for your own use or an immediate family member’s, as long as it contains no controlled drugs, psychotropic substances or prohibited items. Keep the product in its original labelled packaging and keep a copy of your prescription or doctor’s letter with it. Quantities above three months’ supply, and medicines containing controlled substances, require prior HSA approval.

Is Glucophage XR 1000mg Tablet registered with the authorities?

Products listed on DoctorOnCall are registered with Malaysia’s Ministry of Health for supply in Malaysia, and each pack carries its MAL registration number.

An order delivered to Singapore arrives as a personal import of a Malaysia-registered product; HSA product registration is not required for personal-use quantities, but it is also not the same as a product registered for sale in Singapore. If you need a locally registered Singapore product, buy it from a pharmacy in Singapore.

Who do I contact if there is a problem with my order?

DoctorOnCall’s customer care team handles order, delivery and product queries through the contact channels on the site, including WhatsApp and the online help centre.

For deliveries to Singapore, allow more time before chasing an order than you would for a local Malaysian delivery, as the parcel passes through customs clearance and tracking updates can appear later in the journey.

Ingredients / Active Ingredients

  • Metformin Hydrochloride 1000mg (active ingredient, extended-release formulation)
  • Hypromellose and other polymers forming the extended-release matrix
  • Magnesium stearate as a lubricant
  • Film-coating agents as used in the branded formulation

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Glucophage XR 1000mg Tablet offers a once-daily dosing option at the highest standard Metformin strength, which many patients find more convenient than splitting an equivalent immediate-release dose across multiple meals. As with all Metformin-containing medicines, kidney function is assessed before treatment starts and monitored periodically thereafter, and DoctorOnCall’s online consultation process ensures these checks are in place before the prescription is confirmed or renewed.

Medical Review

Written by:

Dr. Chong Zhan Pong

Doctor of Medicine (MD), International Medical University (IMU)

Reviewed by:

Dr. Mohd Izzat Amir Bin Awang

Doctor of Medicine (MD), University of Mansoura - Manchester

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Important Medical Information

💊 Recommended Dosage:

The dose of Glucophage XR 1000mg Tablet is individualised by the prescribing doctor, typically as part of a gradual increase from a lower XR strength based on blood glucose control and tolerability. Because it is an extended-release formulation, the total daily dose is generally taken as a single dose with the evening meal rather than split across the day, and any change should only be made by the doctor after reviewing blood glucose readings and kidney function.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to metformin
  • Moderate to severe kidney impairment, as assessed by the prescribing doctor
  • Acute conditions with risk of altered kidney function, such as severe dehydration, serious infection, or shock
  • Unstable or acute decompensated heart failure
  • Conditions predisposing to tissue hypoxia, such as acute heart attack or severe respiratory failure
  • Planned use of iodinated contrast dye for imaging, unless timed by the doctor around the procedure
  • Any condition causing significant narrowing of the gastrointestinal tract, which may affect passage of the tablet matrix
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.