Do I need a prescription to buy Glucovance 500mg/2.5mg Tablet?

No. Glucovance 500mg/2.5mg Tablet is a non-prescription product and can be ordered without a prescription. It is still dispensed by a registered pharmacist on DoctorOnCall.

What does Glucovance 500mg/2.5mg Tablet contain?

Glucovance 500mg/2.5mg Tablet is a tablet containing Metformin hydrochloride 500mg and Glibenclamide 2.5mg. The full ingredient list is shown in the Composition or Ingredients section on this page and on the product packaging.

What pack sizes does Glucovance 500mg/2.5mg Tablet come in?

It is supplied in pack sizes of 120s and 20s. Choose the pack size you need from the options shown on this page before adding the item to your cart.

Why is there no information here about what Glucovance 500mg/2.5mg Tablet is for?

This page is limited to product, safety and handling information in line with Malaysian rules on medicine information. If you want advice on whether this product suits you, book an online consultation with a doctor or pharmacist on DoctorOnCall.

How should I use Glucovance 500mg/2.5mg Tablet?

Use it exactly as stated on the pack label, without changing the amount or how often you use it. If anything on the label is unclear, check with a pharmacist before the first use, and read the Directions for Use section on this page.

Can I speak to a doctor or pharmacist about Glucovance 500mg/2.5mg Tablet before I buy it?

Yes. DoctorOnCall offers online consultations with licensed doctors and registered pharmacists, so you can ask about this product, your existing medicines, or anything on the label before you place an order.

What should I do if I notice side effects after using Glucovance 500mg/2.5mg Tablet?

Stop using the product and speak to a doctor or pharmacist about any reaction that concerns you. Seek medical care immediately for signs of a severe reaction such as difficulty breathing, swelling of the face, lips or throat, or a widespread rash. Reported reactions are listed in the Side Effects section on this page.

How long will delivery take?

Within Malaysia, standard delivery takes 3 to 5 working days. Same-day delivery is available in the Klang Valley for orders placed before 12pm; orders placed after 12pm arrive by the end of the next day. Orders to Singapore are sent as international deliveries and take 5 to 9 working days. A lump-sum shipping and handling fee applies to every overseas delivery and is shown at checkout.

What payment methods can I use?

Customers in Malaysia can pay by FPX online banking, credit or debit card (Visa and Mastercard), and supported e-wallets including Touch ‘n Go eWallet, GrabPay and ShopeePay. FPX and local e-wallets are tied to Malaysian bank and wallet accounts, so if your delivery address is in Singapore, use the payment options displayed at checkout for that address rather than assuming the same list applies.

Can Glucovance 500mg/2.5mg Tablet be delivered to Singapore?

Yes. DoctorOnCall ships to Singapore as an international order dispatched from Malaysia, arriving in 5 to 9 working days with a lump-sum shipping and handling fee. Singapore’s Health Sciences Authority (HSA) allows personal imports of up to three months’ supply of a medicine for your own use or an immediate family member’s, as long as it contains no controlled drugs, psychotropic substances or prohibited items. Keep the product in its original labelled packaging and keep a copy of your prescription or doctor’s letter with it. Quantities above three months’ supply, and medicines containing controlled substances, require prior HSA approval.

Is Glucovance 500mg/2.5mg Tablet registered with the authorities?

Products listed on DoctorOnCall are registered with Malaysia’s Ministry of Health for supply in Malaysia, and each pack carries its MAL registration number. An order delivered to Singapore arrives as a personal import of a Malaysia-registered product; HSA product registration is not required for personal-use quantities, but it is also not the same as a product registered for sale in Singapore. If you need a locally registered Singapore product, buy it from a pharmacy in Singapore.

Who do I contact if there is a problem with my order?

DoctorOnCall’s customer care team handles order, delivery and product queries through the contact channels on the site, including WhatsApp and the online help centre. For deliveries to Singapore, allow more time before chasing an order than you would for a local Malaysian delivery, as the parcel passes through customs clearance and tracking updates can appear later in the journey.

Glucovance 500/2.5mg Tablet metformin glibenclamide glucose | DoctorOnCall Malaysia

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Glucovance 500mg/2.5mg Tablet

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Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester

Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated: October 31, 2026

Overview

Glucovance 500mg/2.5mg Tablet is supplied as a tablet, with Metformin hydrochloride 500mg and Glibenclamide 2.5mg. It is supplied in pack sizes of 120s and 20s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Glucovance 500mg/2.5mg Tablet should be taken with meals, exactly as prescribed by your doctor, to reduce gastrointestinal side effects and the risk of low blood sugar. It is important to eat regularly and not skip meals while taking this medicine, and to take it at the same times each day as instructed.

Dosage

The dosage of Glucovance 500mg/2.5mg Tablet is individualised based on your current antidiabetic treatment, blood glucose response, and tolerability. Doctors often start combination therapy at this lower glibenclamide-dose strength before considering an increase to a higher-strength Glucovance tablet if blood glucose control is not yet adequate. Do not increase, decrease, or stop your dose without consulting your doctor.

Shelf Life

Glucovance 500mg/2.5mg Tablet has a shelf life of approximately 24 to 36 months from the date of manufacture when stored correctly and left unopened. Always check the expiry date printed on the packaging before use and do not use the tablets beyond this date.

Storage Instructions

Store Glucovance 500mg/2.5mg Tablet below 30°C in a cool, dry place away from direct sunlight and moisture, in its original packaging until ready for use. Keep out of the reach and sight of children.

Side Effects

Nausea or vomiting
Diarrhea
Stomach discomfort or cramps
Metallic taste in the mouth
Loss of appetite
Weight loss (in some cases)

Contraindications

Known hypersensitivity to metformin, glibenclamide, other sulfonylureas, or sulfonamide-derived medicines
Type 1 diabetes or diabetic ketoacidosis
Severe kidney impairment
Severe liver impairment
Conditions with a risk of tissue hypoxia, such as recent heart attack, severe heart or respiratory failure
Acute or chronic metabolic acidosis
Pregnancy and breastfeeding
Before procedures requiring iodinated contrast media, as advised by your doctor

Drug / Food Interactions

Alcohol increases the risk of lactic acidosis with metformin and can worsen hypoglycaemia risk with glibenclamide
Iodinated contrast media used in certain imaging procedures may require temporary discontinuation of this medicine
Other antidiabetic medicines, including insulin, may increase the risk of hypoglycaemia when combined
Miconazole and certain other antifungals may increase glibenclamide’s blood-glucose-lowering effect
Diuretics, corticosteroids, and some other medicines may reduce this medicine’s effectiveness or affect kidney function

Quick Tips

Take Glucovance 500mg/2.5mg Tablet with meals to reduce stomach upset and hypoglycaemia risk
Never skip a meal after taking a dose
Carry a fast-acting sugar source such as glucose tablets in case of low blood sugar
Follow your doctor’s plan closely – this lower-dose strength may later be increased if your blood glucose needs further control
Watch for symptoms of lactic acidosis such as unusual muscle pain, difficulty breathing, or severe tiredness, and seek urgent medical attention if these occur
Monitor your blood glucose and kidney function regularly as advised by your doctor

Ingredients / Active Ingredients

Metformin

Metformin hydrochloride 500mg (active ingredient)
Glibenclamide 2.5mg (active ingredient)
Microcrystalline cellulose
Povidone
Magnesium stearate

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Glucovance 500mg/2.5mg Tablet is often chosen as a starting point for combination antidiabetic therapy, giving your body time to adjust to the added glibenclamide effect at a gentler dose before any increase is considered. It works best alongside a controlled-carbohydrate diet and regular physical activity, with regular follow-up to monitor blood glucose, kidney function, and liver function.