Jardiance Duo 12.5mg/1000mgTablet
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Overview
Jardiance Duo 12.5mg/1000mgTablet contains a fixed-dose combination of empagliflozin and metformin 12.5mg/1000mg, used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor and metformin is a biguanide, two complementary classes of oral anti-diabetic medicine.
Metformin works mainly by reducing the amount of glucose produced by the liver and improving the body’s sensitivity to insulin, while empagliflozin works by blocking glucose reabsorption in the kidneys, causing excess glucose to be removed from the body in the urine. Used together, they lower blood glucose through two different, complementary mechanisms.
How it Works
Metformin decreases hepatic glucose production, reduces intestinal glucose absorption, and improves peripheral glucose uptake and insulin sensitivity, without stimulating insulin secretion. Empagliflozin inhibits SGLT2 in the kidney’s proximal tubule, reducing glucose reabsorption from the filtered urine back into the blood and increasing urinary glucose excretion in an insulin-independent manner, which also modestly lowers blood pressure and body weight.
Directions for Use
Take Jardiance Duo 12.5mg/1000mgTablet with meals, usually twice daily as directed by your doctor, to reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew it. Drink adequate fluids during the day, and continue following your prescribed diet and exercise plan alongside this medicine.
Dosage
The dose of Jardiance Duo 12.5mg/1000mgTablet is individualised by your doctor based on your current metformin dose and blood sugar control, and is generally taken twice daily with meals. Your doctor will adjust the dose gradually and monitor your kidney function, as the metformin component requires dose adjustment or avoidance when kidney function is significantly reduced.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea or vomiting
- Diarrhea
- Stomach discomfort or cramps
- Metallic taste in the mouth
- Loss of appetite
- Weight loss (in some cases)
Contraindications
- Known hypersensitivity to empagliflozin, metformin, or any ingredient in this product
- Severe kidney impairment or acute kidney injury
- Acute conditions that may alter kidney function or cause tissue hypoxia (e.g. dehydration, severe infection, shock, acute heart failure)
- Metabolic acidosis, including diabetic ketoacidosis
- Severe liver impairment
Drug / Food Interactions
- Iodinated contrast media used in some X-ray/CT scans may temporarily increase the risk of kidney problems – metformin may need to be paused around the procedure
- Alcohol may increase the risk of lactic acidosis and low blood sugar
- Diuretics may increase the risk of dehydration and volume depletion when combined with empagliflozin
- Other anti-diabetic medicines (e.g. sulfonylureas, insulin) may increase the risk of low blood sugar (hypoglycaemia)
Quick Tips
- Take with meals to reduce stomach upset
- Drink enough water each day to stay well hydrated
- Practise good genital hygiene to reduce the risk of yeast infections
- Tell your doctor if you are having surgery, a contrast X-ray/CT scan, or become seriously unwell, as this medicine may need to be temporarily stopped
Frequently Asked Questions
What is Jardiance Duo 12.5mg/1000mgTablet used for?
Jardiance Duo 12.5mg/1000mgTablet combines two medicines, empagliflozin and metformin, and is used together with diet and exercise to control blood sugar in adults with type 2 diabetes. Your doctor will confirm the specific reason it has been prescribed for you.
Why do I need to drink more water while taking this medicine?
Empagliflozin causes extra glucose – and some fluid – to be passed out in your urine, so staying well hydrated helps reduce the risk of dehydration and urinary tract infections.
Can this medicine cause low blood sugar on its own?
Empagliflozin and metformin alone rarely cause low blood sugar, but the risk increases if combined with other diabetes medicines such as sulfonylureas or insulin. Discuss your individual risk with your doctor.
Do I need to stop this medicine before a scan or surgery?
Yes, your doctor or the hospital may ask you to temporarily stop this medicine before certain contrast X-ray/CT scans or surgery, because of the metformin component’s effect on kidney function, and restart it once your kidney function is confirmed normal.
What should I do if I miss a dose of Jardiance Duo 12.5mg/1000mgTablet?
Take the missed dose with your next meal as soon as you remember, unless it is almost time for your next scheduled dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Jardiance Duo 12.5mg/1000mgTablet from DoctorOnCall?
Yes, Jardiance Duo 12.5mg/1000mgTablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Jardiance Duo 12.5mg/1000mgTablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Jardiance Duo 12.5mg/1000mgTablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Jardiance Duo 12.5mg/1000mgTablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Jardiance Duo 12.5mg/1000mgTablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Jardiance Duo 12.5mg/1000mgTablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Empagliflozin 12.5mg
- Metformin Hydrochloride 1000mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
