Jardiance Duo 12.5mg/850mg Tablet
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Overview
Jardiance Duo 12.5mg/850mg Tablet is a fixed-dose combination tablet containing empagliflozin 12.5mg and metformin 850mg, made up of a sodium-glucose co-transporter-2 (SGLT2) inhibitor and a biguanide. It is used, together with diet and exercise, to improve blood glucose control in adults with type 2 diabetes mellitus.
Empagliflozin works by blocking SGLT2 in the kidney, so more glucose is excreted in the urine instead of being reabsorbed into the blood, while metformin reduces glucose production by the liver and improves the body’s sensitivity to insulin. Combining both mechanisms in one tablet lowers blood glucose through two complementary pathways.
How it Works
Empagliflozin inhibits SGLT2 transporters in the kidney’s proximal tubule, reducing glucose reabsorption and increasing urinary glucose excretion in an insulin-independent manner. Metformin lowers hepatic glucose output (gluconeogenesis), decreases intestinal glucose absorption, and increases peripheral tissue sensitivity to insulin. Together they lower blood glucose through mechanisms that do not rely on stimulating additional insulin secretion.
Directions for Use
Take Jardiance Duo 12.5mg/850mg Tablet with meals to reduce the stomach upset that metformin can cause, swallowing the tablet whole without crushing or chewing it. Maintain adequate fluid intake, particularly during illness, hot weather, or reduced food/fluid intake, since dehydration can affect kidney function and increase the risk of side effects from both components.
Dosage
Jardiance Duo 12.5mg/850mg Tablet is usually taken once or twice daily depending on the specific strength prescribed, with your doctor selecting the combination and frequency based on your current empagliflozin and metformin doses, blood glucose control, and kidney function. Your doctor will individualise and periodically review your dose, including checking kidney function before and during treatment.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea or vomiting
- Diarrhea
- Stomach discomfort or cramps
- Metallic taste in the mouth
- Loss of appetite
- Weight loss (in some cases)
Contraindications
- Known hypersensitivity to empagliflozin, metformin, or any ingredient in this product
- Severe kidney impairment or acute kidney injury
- Diabetic ketoacidosis or a history of it
- Acute or chronic metabolic acidosis
- Conditions predisposing to tissue hypoxia (e.g. severe heart failure, respiratory failure, recent heart attack) due to lactic acidosis risk with metformin
Drug / Food Interactions
- Diuretics may increase the risk of dehydration and low blood pressure when combined with empagliflozin
- Iodinated contrast media used in imaging studies require metformin to be temporarily withheld due to acute kidney injury and lactic acidosis risk
- Alcohol increases the risk of lactic acidosis with metformin and should be limited
- Other glucose-lowering medicines (e.g. sulfonylureas, insulin) may increase the risk of low blood sugar (hypoglycaemia) when combined
Quick Tips
- Take with food to reduce stomach upset from the metformin component
- Maintain good hydration, especially in hot weather, during illness, or if you are eating/drinking less than usual
- Practise good genital hygiene and seek prompt treatment for any signs of a genital or urinary infection
- Inform your doctor before any surgery, contrast imaging scan, or major illness, as this medicine may need to be temporarily stopped
- Monitor your blood glucose as advised and know the symptoms of both high and low blood sugar
Frequently Asked Questions
What is Jardiance Duo 12.5mg/850mg Tablet used for?
Jardiance Duo 12.5mg/850mg Tablet combines empagliflozin and metformin to help control blood glucose in adults with type 2 diabetes, working through two different mechanisms alongside diet and exercise.
Why does this medicine cause genital infections?
Empagliflozin works by increasing the amount of glucose excreted in urine, which creates an environment where yeast and bacteria can grow more easily around the genital area, increasing the risk of infections such as thrush. Good hygiene and prompt treatment of any symptoms help manage this risk.
Can I take this medicine if I have kidney problems?
Empagliflozin and metformin both depend on adequate kidney function, and this combination is not suitable for people with severe kidney impairment because of a higher risk of lactic acidosis and reduced effectiveness. Your doctor will check your kidney function before starting and periodically during treatment.
Do I need to stop this medicine before a scan with contrast dye or surgery?
Yes, your doctor or the hospital may instruct you to temporarily stop this medicine before and after receiving iodinated contrast dye for an X-ray/CT scan, or before major surgery, because of an increased risk of kidney problems and lactic acidosis. Always tell any doctor treating you that you are on this medicine.
Will this medicine cause low blood sugar (hypoglycaemia)?
Taken alone, this combination has a low risk of causing hypoglycaemia, but the risk increases if it is combined with other diabetes medicines such as sulfonylureas or insulin. Know the signs of low blood sugar (shakiness, sweating, confusion) and how to treat it if it occurs.
What should I do if I miss a dose of Jardiance Duo 12.5mg/850mg Tablet?
Take the missed dose with food as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not take two doses at once.
Can I buy Jardiance Duo 12.5mg/850mg Tablet from DoctorOnCall?
Yes, Jardiance Duo 12.5mg/850mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Jardiance Duo 12.5mg/850mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Jardiance Duo 12.5mg/850mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Jardiance Duo 12.5mg/850mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Jardiance Duo 12.5mg/850mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Jardiance Duo 12.5mg/850mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Empagliflozin 12.5mg
- Metformin hydrochloride 850mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
