Kombiglyze XR 5mg/1000mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

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Overview

Kombiglyze XR 5mg/1000mg Tablet is a prescription-only medicine (POM) that contains Saxagliptin 5mg (as saxagliptin hydrochloride) and Metformin hydrochloride (extended-release) 1000mg. It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Kombiglyze XR 5mg/1000mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Kombiglyze XR 5mg/1000mg Tablet once daily with the evening meal. Swallow the tablet whole with a glass of water – do not crush, cut, or chew it, as this would disrupt the extended-release action of the metformin component.

Dosage

The usual dose of Kombiglyze XR 5mg/1000mg Tablet is one tablet once daily, taken with the evening meal, but your doctor will individualise the exact strength and regimen based on your current metformin dose, kidney function, and blood glucose control. Do not adjust your dose without medical advice.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to saxagliptin, metformin, or any ingredient in this product
  • Severe kidney impairment or acute conditions with risk of altered kidney function (dehydration, severe infection, shock)
  • Metabolic acidosis, including diabetic ketoacidosis
  • Conditions predisposing to tissue hypoxia (e.g. decompensated heart failure, recent heart attack, respiratory failure)
  • History of a serious hypersensitivity reaction to a DPP-4 inhibitor

Drug / Food Interactions

  • Iodinated contrast media used in imaging studies may temporarily impair kidney function – metformin may need to be withheld around the procedure as advised by your doctor
  • Other diabetes medicines (sulfonylureas, insulin) may increase the risk of low blood sugar (hypoglycaemia) when combined
  • Alcohol can increase the risk of lactic acidosis with metformin and should be limited
  • Certain diuretics, corticosteroids, and other medicines that raise blood sugar may reduce this medicine’s effectiveness – inform your doctor of all medicines you are taking

Quick Tips

  • Take with the evening meal to reduce stomach upset and support absorption
  • Attend regular blood glucose, HbA1c, and kidney function monitoring as scheduled
  • Seek urgent medical care for severe abdominal pain, unusual muscle pain, or breathing difficulty
  • Carry a fast-acting source of sugar if you also take insulin or a sulfonylurea, in case of hypoglycaemia
  • Inform your doctor before any surgery or imaging procedure involving contrast dye

Ingredients / Active Ingredients

  • Saxagliptin 5mg (as saxagliptin hydrochloride)
  • Metformin hydrochloride (extended-release) 1000mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandAstraZeneca
ClassificationPrescription medicine
Ingredients / Active IngredientsMetformin
Pack Size28s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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Important Medical Information

💊 Recommended Dosage:

The usual dose of Kombiglyze XR 5mg/1000mg Tablet is one tablet once daily, taken with the evening meal, but your doctor will individualise the exact strength and regimen based on your current metformin dose, kidney function, and blood glucose control. Do not adjust your dose without medical advice.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to saxagliptin, metformin, or any ingredient in this product
  • Severe kidney impairment or acute conditions with risk of altered kidney function (dehydration, severe infection, shock)
  • Metabolic acidosis, including diabetic ketoacidosis
  • Conditions predisposing to tissue hypoxia (e.g. decompensated heart failure, recent heart attack, respiratory failure)
  • History of a serious hypersensitivity reaction to a DPP-4 inhibitor
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.