Proglutrol 500mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Proglutrol 500mg Tablet contains Metformin hydrochloride 500mg and is presented as a tablet. It is supplied in a pack size of 100s.

It is classified as a non-prescription medicine, so no prescription is needed to order it. Under Malaysian rules for medicine information, this page carries product, safety and handling information only.

You can consult a doctor or pharmacist online on DoctorOnCall about this product before or after you order. Every order is checked by a registered pharmacist before it is delivered. Always read the label and the leaflet supplied with the pack.

Directions for Use

Take Proglutrol 500mg Tablet exactly as prescribed by your doctor, generally with or immediately after meals to reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew it unless your doctor advises otherwise. Continue taking it regularly even if you feel well, as diabetes often has no obvious symptoms, and do not stop treatment without consulting your doctor.

Dosage

The starting dose and titration schedule are determined by your doctor based on your blood sugar levels, kidney function, and response to treatment, typically beginning at a low dose that is gradually increased to reduce gastrointestinal side effects. Doses are usually divided across two or three meals per day, and the maximum dose should not exceed the limit set by your doctor.

Storage Instructions

Store Proglutrol 500mg Tablet below 30°C in a dry place, away from direct sunlight and moisture, and keep it out of the reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Severe kidney impairment or acute kidney injury
  • Metabolic acidosis, including diabetic ketoacidosis
  • Severe liver disease
  • Conditions causing tissue hypoxia, such as severe heart failure or respiratory failure
  • Acute conditions with risk of altered kidney function, such as severe dehydration or serious infection
  • Known hypersensitivity to metformin

Drug / Food Interactions

  • Iodinated contrast media used in imaging procedures may require temporary discontinuation of metformin
  • Alcohol increases the risk of lactic acidosis and should be limited
  • Certain diuretics, corticosteroids, and other medicines that affect blood sugar or kidney function may require dose adjustment
  • Concurrent use with other glucose-lowering medicines or insulin may increase the risk of hypoglycaemia
  • Cimetidine may increase metformin blood levels

Quick Tips

  • Take Proglutrol 500mg Tablet with meals to minimise stomach upset
  • Monitor your blood sugar as advised by your doctor and keep a record for follow-up visits
  • Inform your doctor before any procedure involving contrast dye or planned surgery
  • Maintain a healthy diet and regular physical activity alongside your medication
  • Do not stop treatment abruptly without consulting your doctor, even if you feel well
  • Seek urgent medical attention if you experience unusual muscle pain, breathing difficulty, or severe tiredness, which may signal lactic acidosis

Ingredients / Active Ingredients

  • Metformin hydrochloride 500mg
  • Povidone
  • Magnesium stearate
  • Microcrystalline cellulose
  • Hypromellose (tablet coating)
  • Talc

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Because metformin is cleared through the kidneys, your doctor at DoctorOnCall will consider your kidney function, age, and any other medical conditions before prescribing Proglutrol 500mg Tablet, and periodic monitoring of kidney function and vitamin B12 levels may be recommended during long-term use.

Frequently Asked Questions

Product Specifications

ClassificationNon-prescription
Ingredients / Active IngredientsMetformin
Pack Size100s
Shelf LifeProglutrol 500mg Tablet remains stable until the expiry date printed on the packaging when stored correctly and left unopened. Do not use the tablets after this date has passed.

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Important Medical Information

💊 Recommended Dosage:

The starting dose and titration schedule are determined by your doctor based on your blood sugar levels, kidney function, and response to treatment, typically beginning at a low dose that is gradually increased to reduce gastrointestinal side effects. Doses are usually divided across two or three meals per day, and the maximum dose should not exceed the limit set by your doctor.

🛑 Contraindications (Do not use if):
  • Severe kidney impairment or acute kidney injury
  • Metabolic acidosis, including diabetic ketoacidosis
  • Severe liver disease
  • Conditions causing tissue hypoxia, such as severe heart failure or respiratory failure
  • Acute conditions with risk of altered kidney function, such as severe dehydration or serious infection
  • Known hypersensitivity to metformin
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.