Proglutrol G2 2/500mg SR Tablet

Proglutrol G2 2/500mg SR Tablet is a combination antidiabetic medicine containing Glimepiride 2mg, a sulfonylurea, and Metformin Hydrochloride 500mg in a sustained-release (SR) formulation, a biguanide. It is used together with diet and exercise for the management of type 2 diabetes mellitus in patients who require more than one mechanism of blood glucose control, combining a medicine that stimulates insulin release from the pancreas with one that reduces glucose production by the liver and improves insulin sensitivity.

Proglutrol G2 2/500mg SR Tablet is classified as a prescription-only medicine in Malaysia. Combination antidiabetic therapy requires careful individualisation by a doctor, including monitoring of kidney function, blood glucose levels, and risk of hypoglycaemia (low blood sugar). Through DoctorOnCall, customers can complete an online consultation with a registered doctor who will review their medical history and current diabetes control and, if appropriate, issue a prescription so the medicine can be dispensed safely.

Glimepiride works by stimulating the beta cells of the pancreas to release more insulin, helping to lower blood glucose levels. Metformin, in its sustained-release form, works differently by reducing glucose production in the liver, decreasing intestinal glucose absorption, and improving the body’s sensitivity to insulin in muscle and fat tissue. Together, these two mechanisms provide complementary blood sugar control, with the sustained-release formulation of Metformin releasing the medicine gradually over time for steadier drug levels and generally better gastrointestinal tolerability.

Proglutrol G2 2/500mg SR Tablet should be taken exactly as prescribed by the doctor, typically once daily with the main meal of the day, and swallowed whole without crushing or chewing to preserve the sustained-release action. It should be taken at a consistent time each day, and blood glucose levels should be monitored as advised by the prescribing doctor to check the treatment is working effectively.

The dose of Proglutrol G2 2/500mg SR Tablet is individualised by the prescribing doctor based on blood glucose control, kidney function, and response to treatment, and should not be adjusted without medical advice. Missing meals after taking this medicine can increase the risk of hypoglycaemia, so dosing should always be aligned with meal timing as directed.

Proglutrol G2 2/500mg SR Tablet should be used before the expiry date printed on the blister strip and outer carton. Do not use the tablets beyond this date, as effectiveness and safety cannot be guaranteed thereafter.

Store Proglutrol G2 2/500mg SR Tablet below 30°C in a dry place, away from direct sunlight and moisture. Keep tablets in their original packaging until ready for use, and keep out of the reach of children.

• Type 1 diabetes mellitus or diabetic ketoacidosis
• Severe renal impairment
• Severe hepatic impairment
• Known hypersensitivity to glimepiride, metformin, or sulfonylureas
• Conditions predisposing to lactic acidosis, such as severe dehydration or acute illness
• Use of iodinated contrast media (metformin may need to be temporarily withheld)

• Alcohol may increase the risk of lactic acidosis and hypoglycaemia
• Certain diuretics and corticosteroids may raise blood glucose and reduce effectiveness
• Other antidiabetic medicines or insulin may increase hypoglycaemia risk if combined without adjustment
• NSAIDs and some antibiotics may affect glucose control or kidney function
• Inform your doctor of all other medicines, supplements, and herbal products you are taking

• Take with the main meal of the day to reduce gastrointestinal side effects and hypoglycaemia risk
• Swallow the tablet whole; do not crush, split, or chew it
• Monitor blood glucose regularly as advised by your doctor
• Recognise the signs of hypoglycaemia (shakiness, sweating, confusion) and carry a fast-acting sugar source
• Attend regular follow-up appointments to monitor kidney function and overall diabetes control

Proglutrol G2 2/500mg SR Tablet combines two well-established classes of oral antidiabetic medicine and is generally prescribed when a single agent is insufficient to achieve target blood glucose control. Regular monitoring of kidney function, HbA1c, and vitamin B12 status (with long-term use) is recommended, and any illness causing dehydration, vomiting, or reduced food intake should be discussed promptly with a doctor.