Do I need a prescription to buy Proglutrol G2 2/500mg SR Tablet?

No. Proglutrol G2 2/500mg SR Tablet is a non-prescription product and can be ordered without a prescription. It is still dispensed by a registered pharmacist on DoctorOnCall.

What does Proglutrol G2 2/500mg SR Tablet contain?

Proglutrol G2 2/500mg SR Tablet is a tablet containing Glimepiride 2mg. The full ingredient list is shown in the Composition or Ingredients section on this page and on the product packaging.

What pack sizes does Proglutrol G2 2/500mg SR Tablet come in?

It is supplied in pack sizes of 100s and 10s. Choose the pack size you need from the options shown on this page before adding the item to your cart.

Why is there no information here about what Proglutrol G2 2/500mg SR Tablet is for?

This page is limited to product, safety and handling information in line with Malaysian rules on medicine information. If you want advice on whether this product suits you, book an online consultation with a doctor or pharmacist on DoctorOnCall.

How should I use Proglutrol G2 2/500mg SR Tablet?

Follow the instructions printed on the label and in the leaflet supplied with the pack, and do not exceed the stated amount or duration. Handling steps are set out in the Directions for Use section on this page.

Can I speak to a doctor or pharmacist about Proglutrol G2 2/500mg SR Tablet before I buy it?

Yes. DoctorOnCall offers online consultations with licensed doctors and registered pharmacists, so you can ask about this product, your existing medicines, or anything on the label before you place an order.

What should I do if I notice side effects after using Proglutrol G2 2/500mg SR Tablet?

Stop using the product and speak to a doctor or pharmacist about any reaction that concerns you. Seek medical care immediately for signs of a severe reaction such as difficulty breathing, swelling of the face, lips or throat, or a widespread rash. Reported reactions are listed in the Side Effects section on this page.

How long will delivery take?

Within Malaysia, standard delivery takes 3 to 5 working days. Same-day delivery is available in the Klang Valley for orders placed before 12pm; orders placed after 12pm arrive by the end of the next day. Orders to Singapore are sent as international deliveries and take 5 to 9 working days. A lump-sum shipping and handling fee applies to every overseas delivery and is shown at checkout.

What payment methods can I use?

Customers in Malaysia can pay by FPX online banking, credit or debit card (Visa and Mastercard), and supported e-wallets including Touch ‘n Go eWallet, GrabPay and ShopeePay. FPX and local e-wallets are tied to Malaysian bank and wallet accounts, so if your delivery address is in Singapore, use the payment options displayed at checkout for that address rather than assuming the same list applies.

Can Proglutrol G2 2/500mg SR Tablet be delivered to Singapore?

Yes. DoctorOnCall ships to Singapore as an international order dispatched from Malaysia, arriving in 5 to 9 working days with a lump-sum shipping and handling fee. Singapore’s Health Sciences Authority (HSA) allows personal imports of up to three months’ supply of a medicine for your own use or an immediate family member’s, as long as it contains no controlled drugs, psychotropic substances or prohibited items. Keep the product in its original labelled packaging and keep a copy of your prescription or doctor’s letter with it. Quantities above three months’ supply, and medicines containing controlled substances, require prior HSA approval.

Is Proglutrol G2 2/500mg SR Tablet registered with the authorities?

Products listed on DoctorOnCall are registered with Malaysia’s Ministry of Health for supply in Malaysia, and each pack carries its MAL registration number. An order delivered to Singapore arrives as a personal import of a Malaysia-registered product; HSA product registration is not required for personal-use quantities, but it is also not the same as a product registered for sale in Singapore. If you need a locally registered Singapore product, buy it from a pharmacy in Singapore.

Who do I contact if there is a problem with my order?

DoctorOnCall’s customer care team handles order, delivery and product queries through the contact channels on the site, including WhatsApp and the online help centre. For deliveries to Singapore, allow more time before chasing an order than you would for a local Malaysian delivery, as the parcel passes through customs clearance and tracking updates can appear later in the journey.

Proglutrol G2 2/500mg SR Tablet | glibenclamide metformin | type 2 diabetes sustained-release tablet | DoctorOnCall Malaysia

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Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester

Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated: October 18, 2026

Overview

Proglutrol G2 2/500mg SR Tablet is a tablet with Glimepiride 2mg declared as its active content. It is supplied in pack sizes of 100s and 10s.

This is a non-prescription product and can be purchased without a prescription. Only product, safety and handling details are published on this page.

An online consultation with a DoctorOnCall doctor or pharmacist is available for this product, and a registered pharmacist reviews each order before dispatch to Malaysia or Singapore. Follow the directions on the label and on the leaflet inside the pack.

Directions for Use

Proglutrol G2 2/500mg SR Tablet should be taken exactly as prescribed by the doctor, typically once daily with the main meal of the day, and swallowed whole without crushing or chewing to preserve the sustained-release action. It should be taken at a consistent time each day, and blood glucose levels should be monitored as advised by the prescribing doctor to check the treatment is working effectively.

Dosage

The dose of Proglutrol G2 2/500mg SR Tablet is individualised by the prescribing doctor based on blood glucose control, kidney function, and response to treatment, and should not be adjusted without medical advice. Missing meals after taking this medicine can increase the risk of hypoglycaemia, so dosing should always be aligned with meal timing as directed.

Storage Instructions

Store Proglutrol G2 2/500mg SR Tablet below 30°C in a dry place, away from direct sunlight and moisture. Keep tablets in their original packaging until ready for use, and keep out of the reach of children.

Side Effects

Nausea or vomiting
Diarrhea
Stomach discomfort or cramps
Metallic taste in the mouth
Loss of appetite
Weight loss (in some cases)

Contraindications

Type 1 diabetes mellitus or diabetic ketoacidosis
Severe renal impairment
Severe hepatic impairment
Known hypersensitivity to glimepiride, metformin, or sulfonylureas
Conditions predisposing to lactic acidosis, such as severe dehydration or acute illness
Use of iodinated contrast media (metformin may need to be temporarily withheld)

Drug / Food Interactions

Alcohol may increase the risk of lactic acidosis and hypoglycaemia
Certain diuretics and corticosteroids may raise blood glucose and reduce effectiveness
Other antidiabetic medicines or insulin may increase hypoglycaemia risk if combined without adjustment
NSAIDs and some antibiotics may affect glucose control or kidney function
Inform your doctor of all other medicines, supplements, and herbal products you are taking

Quick Tips

Take with the main meal of the day to reduce gastrointestinal side effects and hypoglycaemia risk
Swallow the tablet whole; do not crush, split, or chew it
Monitor blood glucose regularly as advised by your doctor
Recognise the signs of hypoglycaemia (shakiness, sweating, confusion) and carry a fast-acting sugar source
Attend regular follow-up appointments to monitor kidney function and overall diabetes control

Ingredients / Active Ingredients

Metformin

Glimepiride 2mg
Metformin Hydrochloride 500mg (sustained-release)

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Proglutrol G2 2/500mg SR Tablet combines two well-established classes of oral antidiabetic medicine and is generally prescribed when a single agent is insufficient to achieve target blood glucose control. Regular monitoring of kidney function, HbA1c, and vitamin B12 status (with long-term use) is recommended, and any illness causing dehydration, vomiting, or reduced food intake should be discussed promptly with a doctor.

Frequently Asked Questions

Product Specifications

Classification	Non-prescription
Ingredients / Active Ingredients	Metformin
Pack Size	100s, 10s
Shelf Life	Proglutrol G2 2/500mg SR Tablet should be used before the expiry date printed on the blister strip and outer carton. Do not use the tablets beyond this date, as effectiveness and safety cannot be guaranteed thereafter.