Diamide 5mg/500mg Tablet

Brand Hovid
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Diamide 5mg/500mg Tablet is supplied as a tablet, with Glibenclamide 5mg. It is supplied in pack sizes of 10s and 120s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Diamide tablets should be taken exactly as prescribed by your doctor, typically with meals to reduce the risk of stomach upset and to help align the medicine’s effect with rising blood glucose after eating. It should not be skipped, doubled up, or stopped without medical advice, and blood glucose should be monitored as advised by your healthcare provider.

Dosage

The dose of Diamide is individualised based on blood glucose control, kidney function, and response to treatment, and must be determined and adjusted by your doctor rather than self-adjusted. Doses are usually started low and increased gradually, and it is important to attend regular follow-up appointments so your doctor can review your HbA1c and blood glucose readings and adjust treatment as needed.

Storage Instructions

Store below 30°C in a dry place away from direct sunlight and moisture, keeping tablets in their original packaging until ready to use. Keep out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to glibenclamide, metformin, other sulfonylureas, or any ingredient in the tablet
  • Type 1 diabetes or diabetic ketoacidosis
  • Significant kidney impairment
  • Severe liver disease
  • Conditions with a risk of tissue hypoxia, such as recent heart attack, severe heart failure, or severe respiratory failure
  • Acute or unstable conditions that may affect kidney function, such as severe dehydration, serious infection, or shock
  • Use of iodinated contrast media requiring temporary discontinuation, as advised by your doctor

Drug / Food Interactions

  • Alcohol may increase the risk of hypoglycaemia and, rarely, lactic acidosis when combined with metformin
  • Other glucose-lowering medicines, including insulin, may increase the risk of hypoglycaemia if not carefully coordinated
  • Corticosteroids, thiazide diuretics, and certain other medicines may raise blood glucose and reduce the effectiveness of Diamide
  • Beta-blockers may mask the warning signs of hypoglycaemia, such as a fast heartbeat
  • Certain antibiotics and other medicines can alter glibenclamide levels; always inform your doctor of all medicines you take

Quick Tips

  • Take Diamide with meals as prescribed to reduce stomach upset and hypoglycaemia risk
  • Always carry a fast-acting source of sugar in case of low blood sugar symptoms such as shakiness, sweating, or confusion
  • Monitor your blood glucose as advised and keep a record to share with your doctor
  • Do not skip meals while taking this medicine
  • Attend regular check-ups to monitor kidney function and overall diabetes control
  • Seek urgent medical attention if you experience unusual muscle pain, difficulty breathing, or severe tiredness, which could indicate a rare but serious side effect

Ingredients / Active Ingredients

  • Glibenclamide 5mg
  • Metformin Hydrochloride 500mg
  • Microcrystalline cellulose
  • Povidone
  • Magnesium stearate
  • Colloidal silicon dioxide

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Diamide is part of a broader diabetes management plan that should also include regular blood glucose monitoring, a balanced diet, physical activity, and periodic laboratory tests such as kidney function and HbA1c, as directed by your doctor. Because it combines two glucose-lowering mechanisms, careful medical supervision is especially important to balance effective blood sugar control against the risk of hypoglycaemia and other side effects.

Frequently Asked Questions

Product Specifications

BrandHovid
ClassificationNon-prescription
Ingredients / Active IngredientsMetformin
Pack Size10s, 120s
Shelf LifeDiamide tablets remain stable until the expiry date printed on the blister pack or carton when stored correctly and unopened; the expiry date should always be checked before use.

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Important Medical Information

💊 Recommended Dosage:

The dose of Diamide is individualised based on blood glucose control, kidney function, and response to treatment, and must be determined and adjusted by your doctor rather than self-adjusted. Doses are usually started low and increased gradually, and it is important to attend regular follow-up appointments so your doctor can review your HbA1c and blood glucose readings and adjust treatment as needed.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to glibenclamide, metformin, other sulfonylureas, or any ingredient in the tablet
  • Type 1 diabetes or diabetic ketoacidosis
  • Significant kidney impairment
  • Severe liver disease
  • Conditions with a risk of tissue hypoxia, such as recent heart attack, severe heart failure, or severe respiratory failure
  • Acute or unstable conditions that may affect kidney function, such as severe dehydration, serious infection, or shock
  • Use of iodinated contrast media requiring temporary discontinuation, as advised by your doctor
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.