Glucophage 1000mg Tablet

Brand Merck
Manufacturer Merck
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Glucophage 1000mg Tablet is supplied as a tablet, with Metformin Hydrochloride 1000mg. It is supplied in pack sizes of 120s and 15s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Glucophage 1000mg Tablet should be taken exactly as prescribed, generally with or immediately after a main meal to reduce stomach-related side effects. At this higher strength, doctors commonly split the daily dose across two meals rather than giving it all at once, so patients should follow their specific dosing schedule rather than assuming a single daily dose. Tablets should be swallowed whole with water and not crushed or chewed unless the doctor has specifically advised otherwise.

Dosage

The dose of Glucophage 1000mg Tablet is individualised by the prescribing doctor based on blood glucose control, kidney function, and response to lower Metformin strengths used earlier in treatment. It is typically part of a total daily Metformin dose that is divided across two main meals rather than taken as a single 1000mg dose, and any adjustment should only be made by the doctor after reviewing blood glucose readings and, where relevant, kidney function tests.

Storage Instructions

Store below 30°C in a dry place, protected from direct light and humidity, and keep tablets in their original blister packaging until they are needed. Keep out of the sight and reach of children at all times.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)

Contraindications

  • Known hypersensitivity to metformin
  • Moderate to severe kidney impairment, as assessed by the prescribing doctor
  • Acute conditions with risk of altered kidney function, such as severe dehydration, serious infection, or shock
  • Uncontrolled or decompensated heart failure, or acute or unstable heart failure
  • Conditions predisposing to tissue hypoxia, such as acute heart attack or severe respiratory failure
  • Planned use of iodinated contrast dye for imaging, unless timed by the doctor around the procedure

Drug / Food Interactions

  • Iodinated contrast media used in certain imaging scans — Metformin may need to be temporarily stopped around the procedure on your doctor’s advice
  • Alcohol — excessive intake increases the risk of lactic acidosis, especially with liver problems or fasting
  • Certain diuretics, corticosteroids, and other medicines that can affect kidney function or blood glucose control
  • Other glucose-lowering medicines or insulin — combined use may increase the risk of low blood sugar and requires monitoring
  • Take with food as directed, as this reduces gastrointestinal side effects

Quick Tips

  • Take Glucophage 1000mg Tablet exactly at the times and with the meals your doctor has specified, since the dose is often split across the day at this strength
  • Never double up a missed dose; simply continue with the next scheduled dose
  • Attend regular follow-ups so kidney function and blood glucose control can be monitored
  • Inform your doctor before any scan involving contrast dye or before surgery
  • Watch for unusual muscle pain, breathing difficulty, or severe tiredness, and seek medical attention promptly if these occur

Ingredients / Active Ingredients

  • Metformin Hydrochloride 1000mg (active ingredient)
  • Povidone and other standard tablet binders
  • Magnesium stearate as a lubricant
  • Film-coating agents as used in the branded formulation

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Glucophage 1000mg Tablet is typically prescribed once a patient’s Metformin requirement has increased beyond the standard starting strengths, and it is usually part of a broader diabetes management plan that also includes diet, physical activity, and periodic blood tests. Because it is a higher tablet strength, doctors pay particular attention to kidney function before and during treatment, and any online consultation through DoctorOnCall will include a review of these factors before the prescription is confirmed or renewed.

Frequently Asked Questions

Product Specifications

BrandMerck
ManufacturerMerck
ClassificationNon-prescription
Ingredients / Active IngredientsMetformin
Pack Size120s, 15s
Shelf LifeGlucophage 1000mg Tablet is generally stable until the expiry date printed on the blister or carton when stored under the recommended conditions. Do not use the tablets beyond the printed expiry date.

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Important Medical Information

💊 Recommended Dosage:

The dose of Glucophage 1000mg Tablet is individualised by the prescribing doctor based on blood glucose control, kidney function, and response to lower Metformin strengths used earlier in treatment. It is typically part of a total daily Metformin dose that is divided across two main meals rather than taken as a single 1000mg dose, and any adjustment should only be made by the doctor after reviewing blood glucose readings and, where relevant, kidney function tests.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to metformin
  • Moderate to severe kidney impairment, as assessed by the prescribing doctor
  • Acute conditions with risk of altered kidney function, such as severe dehydration, serious infection, or shock
  • Uncontrolled or decompensated heart failure, or acute or unstable heart failure
  • Conditions predisposing to tissue hypoxia, such as acute heart attack or severe respiratory failure
  • Planned use of iodinated contrast dye for imaging, unless timed by the doctor around the procedure
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Nausea or vomiting
  • Diarrhea
  • Stomach discomfort or cramps
  • Metallic taste in the mouth
  • Loss of appetite
  • Weight loss (in some cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.