Upha Proezine 5mg Syrup

Manufacturer Duopharma
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

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Overview

Upha Proezine 5mg Syrup is supplied as a syrup, with Promethazine hydrochloride 5mg per 5mL dose. It is supplied in a pack size of 90ml.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Upha Proezine Syrup should only be given according to the exact dose and schedule confirmed by the prescribing doctor following an online consultation via DoctorOnCall. Use the measuring cup or oral syringe provided to measure the dose accurately, shake the bottle well before each use, and give with or after food to reduce the chance of stomach upset.

Dosage

Dosage is individualised by the prescribing doctor based on the patient’s age, body weight, and the condition being treated, and must not be adjusted without medical advice. This medicine requires a valid prescription obtained through an online consultation with a doctor via DoctorOnCall, and should not be given to infants below 2 years of age due to the risk of severe breathing problems.

Shelf Life

Upha Proezine 5mg Syrup is generally stable for up to 24 months from the date of manufacture when unopened and stored correctly; once opened, it should be used within the period stated on the label, typically a few weeks. Always check the expiry date on the bottle before use.

Storage Instructions

Store below 30°C in a cool, dry place away from direct sunlight, and keep the bottle tightly closed when not in use. Keep out of reach and sight of children, and do not use if the syrup shows signs of discolouration or unusual odour.

Side Effects

  • Drowsiness or dizziness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Skin sensitivity to sunlight
  • Confusion (especially in older adults)
  • Restlessness in children

Contraindications

  • Children under 2 years of age, due to the risk of severe or fatal respiratory depression
  • Known hypersensitivity to promethazine or other phenothiazine medicines
  • Severe liver disease
  • Comatose states or severe central nervous system depression
  • Concurrent use with other strong sedating medicines unless directed by a doctor

Drug / Food Interactions

  • Increased sedation when combined with alcohol, sleeping tablets, opioids, or other sedating antihistamines
  • May increase the central nervous system depressant effects of anaesthetics and certain anti-anxiety medicines
  • Should not be combined with monoamine oxidase inhibitors (MAOIs)
  • May mask signs of ototoxicity when taken with certain antibiotics such as aminoglycosides
  • Anticholinergic effects may be increased when combined with other anticholinergic medicines

Quick Tips

  • Only use this syrup exactly as prescribed by your doctor following an online consultation via DoctorOnCall
  • Avoid driving, cycling, or operating machinery after taking this medicine due to sedation
  • Never give this medicine to infants below 2 years old
  • Keep follow-up appointments so your doctor can monitor response and adjust treatment if needed
  • Seek urgent medical attention if breathing becomes difficult or unusual drowsiness occurs, especially in a child

Ingredients / Active Ingredients

  • Promethazine hydrochloride 5mg per 5mL dose
  • Sucrose or sugar-based syrup base
  • Flavouring agent
  • Preservative
  • Purified water

Safety Advice

Pregnancy

Safe If Prescribed

This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Limited Data

Limited data in kidney disease patients. Use only if necessary.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Promethazine-based syrups such as Upha Proezine are prescription-only in Malaysia and Singapore due to well-documented pediatric respiratory risks and significant sedative effects, and are dispensed only after a doctor has reviewed the patient’s suitability through an online consultation. Ongoing monitoring by a doctor or pharmacist is recommended, particularly in young children, the elderly, and patients taking other sedating medicines.

Frequently Asked Questions

Product Specifications

BrandDuopharma
ManufacturerDuopharma
ClassificationNon-prescription
Ingredients / Active IngredientsPromethazine
Volume90ml

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Important Medical Information

💊 Recommended Dosage:

Dosage is individualised by the prescribing doctor based on the patient’s age, body weight, and the condition being treated, and must not be adjusted without medical advice. This medicine requires a valid prescription obtained through an online consultation with a doctor via DoctorOnCall, and should not be given to infants below 2 years of age due to the risk of severe breathing problems.

🛑 Contraindications (Do not use if):
  • Children under 2 years of age, due to the risk of severe or fatal respiratory depression
  • Known hypersensitivity to promethazine or other phenothiazine medicines
  • Severe liver disease
  • Comatose states or severe central nervous system depression
  • Concurrent use with other strong sedating medicines unless directed by a doctor
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Drowsiness or dizziness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Skin sensitivity to sunlight
  • Confusion (especially in older adults)
  • Restlessness in children
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.