Our panel of doctors at DoctorOnCall


Dr Sashini Seeni

General Health

Dr M Ramzdhan

General Health

Dr Nathaniel Ho

General Health

Dr Rashid Khan

General Health

Dr Nurhayati

General Health

Dr Sri Viknarajan

General Health

Dr Fatahiyah

General Health

Dr Nur Syuhada

General Health

Dr Lee Chin Meng

General Health

Dr Mohamad Kashfi

General Health

English and Malay
Our doctors can help you in both languages
Accredited Doctors
All doctors at DoctorOnCall are registered with Health Ministry of Malaysia
Privacy Guaranteed
Your data is safe and will not be revealed to any parties
Quick and Efficient
All queries will be answered by doctors in a quick and efficient manner
*This is a public forum. Please do not put any personal information such as phone numbers, emails as it will be publicly visible
Submit Anonymously

Give a title to your health problem
*Title must be more than 20 characters
Explain in detail what health problem you're having
*Explanation must be more than 20 characters
Please enter your email address so we can send you answer to your question

Malaysia's #1
Health Forum

PCKD and kidney failure?

Answered by: Dr Ramzdhan

Last Updated: July 29, 2019 8:31 AM
zulaiha 13 months

I’m a PCKD patient. I have a question. Does everyone with PCKD develop kidney failure?

Dr Ramzdhan 14 months
General Practitioner

"Hi, thank you for your question.
Polycystic kidney disease (PCKD) is a progressive disease. Kidney failure is one of the many complications of PCKD. On average, glomerular filtration rate (GFR) starts to decrease by approximately 5 mL/min/year in your 40s. By the age of 75, 50 to 75% of patients wll develop kidney failure requiring dialysis or kidney transplantation. The severity and progression of PCKD differs greatly from one person to another, even among members of the same family.

Factors predicting more rapid progression to kidney failure include earlier age of diagnosis, male, mutation in PKD1 gene, larger / rapidly increasing kidney size, hypertension, gross haematuria, worsening proteinuria and sickle cell trait. Kidney and cyst volume measurements are very helpful in predicting the risk of progression to chronic kidney disease (CKD) and end stage renal disease (ESRD), even before changes in blood or urine tests are found.

There is no way to cure PCKD but you may slow down the disease progression by following a healthy lifestyle, for example:

  1. Keep blood pressure, cholesterol and blood sugar levels under control by taking your medications regularly
  2. Eat a healthy diet low in salt
  3. Exercise regularly for at least 30 minutes a day 5 times a week
  4. Maintain a healthy weight
  5. Quit smoking
  6. Drink alcohol in moderation
  7. Take prescribed medications as advised
  8. Do not overdose yourself with over-the-counter medications and supplements

Doctors have also discovered a new drug – vasopressin antagonist Tolvaptan, which could be used to delay disease progression in PCKD patients in long term. New version of this drug – Lixivaptan can help to prevent progression and avoid the need for dialysis or kidney transplantation in PCKD patients.

Last Updated: Mon Jul 29 2019 08:31:00 GMT+0000 (Coordinated Universal Time)
4.88
Online Consultation
Talk to a doctor or Nephrologist Specialist online about kidney problems from anywhere you are without having to queue anymore
Doctor Consult RM19.99 Specialist Consult From RM80
FREE Detailed Health Assessment
Prevention is better than cure. Is My Body Ready to Fight Infection? Find Out in only 5 short minutes!
Start FREE Health Assessment
Ask Doctor For Free 10.10 Health Fest: RM10 off!